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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2003, Number 3

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An Med Asoc Med Hosp ABC 2003; 48 (3)

Hypersensitivity reaction associated to carboplatino

Gerson R, Serrano A, Flores F, Villalobos A

Language: Spanish
References: 10
Page: 137-141
PDF size: 51.14 Kb.


ABSTRACT

Carboplatin, analogue of platinum in a useful antitumoral drug for neoplasms of lung, ovary, bladder, etc. This drug can induce many side effects, like thrombocytopenia, leucopenia, anemia and neuropathies. Their administration has been associated to hypersensitivity reactions (8% to 16% of cases). In this study, we present three cases, two from ovary and one from breast, which developed several degrees of hypersensitivity reactions. We registered data of another six patients also with side effect. In this report, we discus the risk, morbility and mortality related to hypersensitivity reactions by carboplatin, as well as strategies for treatment and prevention of this events.


REFERENCES

  1. Abas AK, Lichtman AH, Pober JS. Mecanismos efectores de las reacciones inmunitarias iniciadas por la inmunoglobulina E. En: Abbas AK. Lichtman AH, Pober JS. Inmunología celular y molecular. 2a ed. Madrid, España: Interamericana-McGraw-Hill, 1995; 312-28

  2. Dorr RT, Von Hoff DD. Carboplatino. In: Cancer chemotherapy handbook. 2nd ed. Connecticut, USA: Appleton-Lange, 1994: 259-266.

  3. Reed E. Cisplatin and analogues. In: Chapner BA, Longo DL. Cancer chemotherapy and biotherapy. 3th ed. Philadelphia, USA: Lippincott, 2002; 447-465.

  4. Markman M, Kernnedy A, Webster K et al. Clinical features of hypersensitivity reactions to carboplatin. J Clin Oncol 1999; 17: 1141-1145.

  5. Polyzos A, Tsavaris N, Kosmas C et al. Hypersensitivity reactions to carboplatin administration are common but not always severe: a ten years experience. Oncology 2001; 61: 129-133.

  6. Sood AK, Gelder MS, Huang SW et al. Anaphylaxis to carboplatin following multiple previous uncomplicate courses. Gynecol Oncol 1995; 57: 131-132.

  7. Chang SM, Fryberger S, Crouse V et al. Carboplatin hypersensitivity in children. A report of five patients with brain tumors. Cancer 1995; 75: 1171-1175.

  8. Weidmann B, Mulleneisen N, Bojko P et al. Hypersensitivity reactions to carboplatin. Report of two patients, review of the literature, and discussion of diagnostic procedures and management. Cancer 1994; 73: 2218-2222.

  9. Zanotti KM, Rybicky LA, Kennedy AW et al. Carboplatin skin testing: a skin testing protocol for predicting hypersensitivity to carboplatin chemotherapy. J Clin Oncol 2001; 19: 3126-3129.

  10. Thomas RR, Quinn MG, Grem JL. Hypersensitivity and idiosyncratic reactions to oxaliplatin. Cancer 2003; 97: 2301-2307.




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