2007, Number 2
<< Back Next >>
Bol Med Hosp Infant Mex 2007; 64 (2)
Weight, fat percentage and maternal bone mineral density are determinants of bone mineral density in adolescent and young adult females
Padilla-Vázquez AV, Lamadrid-Figueroa H, Cruz-Valdez A
Language: Spanish
References: 48
Page: 72-82
PDF size: 162.62 Kb.
ABSTRACT
Introduction. Osteoporosis is a public health problem. It is important to characterize the factors which predispose to a low bone mineral density (BMD) since adolescence.
Material and methods. Twenty eight mother-daughter pairs were studied. BMD was measured by dual X-ray absorptiometry in several anatomic sites, anthropometric measures were obtained. Pearson’s correlations and multiple linear regression models were fitted.
Results. Weight was the factor most correlated with BMD in all anatomic sites. In multiple analysis, maternal BMD was the most determinant factor of spinal BMD (ß =0.363, P =0.01); weight (ß =0.018, P ‹0.01) and fat percentage (ß =-0.013, P =0.02) were in the hip.
Conclusions. Heredity is the most determinant factor of spinal BMD; body size and composition are in the hip. Controlling for weight and height, a greater body fat percentage is associated with a lower BMD in young women.
REFERENCES
Akesson K. New approaches to pharmacological treatment of osteoporosis. Bone and joint decade. Bull World Health Organ. 2003; 81: 657-64.
Lazcano E, Tamayo J, Cruz VA, Díaz R, Hernández B, del Cueto R, et al. Peak bone mineral area density and determinants among females aged 9 to 24 years in Mexico. Osteoporos Int. 2003; 14: 539-47.
World Health Organization. Prevention and management of osteoporosis. World Health Organ Tech Rep Ser. No 921. 2003.
Carrie-Fassler AL, Bonjour JP. Osteoporosis as a pediatric problem. Pediatr Clin North Am. 1995; 42: 811-24.
Ralston SH. Science, medicine and the future: Osteoporosis. BMJ. 1997; 315: 469-72.
Bonjour JP, Theintz G, Buchs B, Slosman D, Rizzoli R. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab. 1991; 73: 555–63.
Hall SE, Williams JA, Senior JA, Goldswain PR, Criddle RA. Hip fracture outcomes: quality of life and functional status in older adults living in the community. Aust N Z J Med. 2000; 30: 327-32.
Delezé M. Osteoporosis. Magnitud del problema en México y a nivel mundial. Impacto socioeconómico. Climaterio. 1998; 1: 141-6.
Zúñiga GS, Galindo EE, Pérez RP. Densidad ósea en mujeres postmenopáusicas en una muestra de población del norte de México. Rev Endocrinol Nutr. 2004; 12: 69-72.
Harlem BG. The burden of musculoskeletal disease: The bone and joint decade 2000-2010. Geneva: WHO; 2000.
Feldstein AC, Elmer PJ, Nichols GA, Herson M. Practice patterns in patients at risk for glucocorticoid-induced osteoporosis. Osteoporos Int. 2005; 16: 2168-74.
Mitchell BD, Kammerer CM, Schneider JL, Perez R, Bauer RL. Genetic and environmental determinants of bone mineral density in Mexican Americans: results from the San Antonio Family. Osteoporos Study Bone. 2003; 33: 839-49.
Rideout CA, Mckay HA, Barr SI. Self-reported lifetime physical activity and area bone mineral density in healthy postmenopausal women: the importance of teenage activity. Calcif Tissue Int. 2006; 79: 214-22.
Borer KT. Physical activity in the prevention and amelioration of osteoporosis in women: interaction of mechanical, hormonal and dietary factors. Sports Med. 2005; 35: 779-830.
Parra CS, Hernandez AM, Tamayo OJ, Lopez CL, Meneses GF. Exercise and reproductive factors as predictors of bone density among osteoporotic women in Mexico City. Calcif Tissue Int. 1996; 59: 89-94.
Picard D, Imbach A, Couturier M, Lepage R, Picard M. Familial resemblance of bone mineral density between females 18 years and older and their mothers. Can J Public Health. 2001; 92: 353-8.
Bruni V, Dei M, Filicetti MF, Balzi D, Pasqua A. Predictors of bone loss in young women with restrictive eating disorders. Pediatr Endocrinol Rev. 2006; 3 Supl 1: 219-21.
Gennari L, Becherini L, Masi L, Mansani R, Gonneli S, Cepollaro C, et al. Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: Evidence of multiple gene contribution to bone mineral density. J Clin Endocrinol Metab. 1998; 83: 939-44.
Lorentzon M, Lorentzon R, Bäckstrom T, Nordstrom P. Estrogen receptor gene polymorphism, but not estradiol levels, is related to bone density in healthy adolescent boys: A cross sectional and longitudinal study. J Clin Endocrinol Metab. 1999; 884: 4597-601.
Morrison N, Qi J, Tokita A, Kelly P, Crofts L, Nguyen T, et al. Prediction of bone density from vitamin D receptor alleles. Nature. 1994; 367: 284-7.
Videman T, Gibbons L, Battié M, Maravilla K, Vanninen E, Leppävuori J, et al. The relative roles of intragenic polymorphisms of the vitamin D receptor gene in lumbar spine degeneration and bone density. Spine. 2001; 26: A1-A6.
Gennari L, Becherini L, Masi L, Mansani R, Gonneli S, Cepollaro C, et al. Vitamin D and estrogen receptor allelic variants in Italian postmenopausal women: Evidence of multiple gene contribution to bone mineral density. J Clin Endocrinol Metab. 1998; 83: 939-44.
Greendale GA, Chu J, Ferrell R, Randolph JF Jr, Johnston JM, Sowers MR. The association of bone mineral density with estrogen receptor gene polymorphisms. Am J Med. 2006; 119 (9 Supl 1): S79-86.
Williams FM, Spector TD. Recent advances in the genetics of osteoporosis. J Musculoskelet Neuronal Interact. 2006; 6: 27-35.
Magana J, Gomez R, Cisneros B, Casas L, Castorena F, Miranda A, et al. Association of the CT gene (CA) polymorphism with BMD in osteoporotic Mexican women. Clin Genet. 2006; 70: 402-8.
Ralston SH, de Crombrugghe B. Genetic regulation of bone mass and susceptibility to osteoporosis. Genes Dev. 2006; 20: 2492-506.
Khosla S, Atkinson EJ, Riggs BL, Melton LJ 3rd. Relationship between body composition and bone mass in women. J Bone Miner Res. 1996; 11: 857-63.
Reid IR. Relationships among body mass, its components, and bone. Bone. 2002; 31: 547-55.
Weiler HA, Janzen L, Green K, Grabowski J, Seshia MM, Yuen KC. Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age. Bone. 2000; 27: 203-7.
Clark EM, Ness AR, Tobias JH. Adipose tissue stimulates bone growth in prepubertal children. J Clin Endocrinol Metab. 2006; 91: 2534-41.
Janicka A, Wren TA, Sanchez MM, Dorey F, Kim PS, Mittelman SD, et al. Fat mass is not beneficial to bone in adolescents and young adults. J Clin Endocrinol Metab. 2007; 92: 143-7.
Petit MA, Beck TJ, Shults J, Zemel BS, Foster BJ, Leonard MB. Proximal femur bone geometry is appropriately adapted to lean mass in overweight children and adolescents. Bone. 2005; 36: 568-76.
Looker AC, Beck TJ. Maternal history of osteoporosis and femur geometry. Calcif Tissue Int. 2004; 75: 277-85.
Saito T, Nakamura Y, Nashimoto M, Yamamoto N, Yamamoto M. Weight gain in childhood and bone mass in female college students. J Bone Miner Metab. 2005; 23: 69-75.
Khosla S, Atkinson L, Melton III J, Riggs L. Effects of age and estrogen status on serum parathyroid hormone levels and biochemical markers of bone turnover in women: a population-based study. J Clin Endocrinol Metab. 1997; 82: 1522-7.
Langlois JA, Mussolino ME, Visser M, Looker AC, Harris T, Madans J. Weight loss from maximum body weight among middle-aged and older white women and the risk of hip fracture: the NHANES I epidemiologic follow-up study. Osteoporos Int. 2001; 12: 763-837.
McGuigan FE, Murray L, Gallagher A, Davey-Smith G, Neville CE, Van’t Hof R, et al. Genetic and environmental determinants of peak bone mass in young men and women. J Bone Miner Res. 2002; 17: 1273-9.
Looker AC, Flegal KM, Melton LJ 3rd. Impact of increased overweight on the projected prevalence of osteoporosis in older women. Osteoporos Int. 2006; 20.
Riancho JA, Zarrabeitia MT, Valero C, Sanudo C, Mijares V, Gonzalez-Macias J. A gene-to-gene interaction between aromatase and estrogen receptors influences bone mineral density. Eur J Endocrinol. 2006; 155: 53-9.
Eastell R, Hannon R. Long-term effects of aromatase inhibitors on bone. J Steroid Biochem Mol Biol. 2005; 95: 151-4.
Compston JE, Bhambhani M, Laskey MA, Murphy S, Khaw KT. Body composition and bone mass in post-menopausal women. Clin Endocrinol. 1992; 37: 426-31.
Chen Z, Lohman TG, Stini WA, Ritenbaugh C, Aickin M. Fat or lean tissue mass: which one is the major determinant of bone mineral mass in healthy postmenopausal women? J Bone Miner Res. 1997; 12: 144-51.
Young D, Hopper JL, Nowson CA, Green RM, Sherwin AJ, Kaymacki B, et al. Changes in body composition as determinants of longitudinal changes in bone mineral measures in 8 to 26-year-old female twins. Osteoporos Int. 2001; 12: 506-15.
Francois S, Benmalek A, Guaydier-Souquieres G, Sabatier JP, Marcelli C. Heritability of bone mineral density. Rev Rhum Engl Ed. 1999; 66: 146-51.
Runyan SM, Stadler DD, Bainbridge CN, Miller SC, Moyer-Mileur LJ. Familial resemblance of bone mineralization, calcium intake, and physical activity in early-adolescent daughters, their mothers, and maternal grandmothers. J Am Diet Assoc. 2003; 103: 1320-5.
Ulrich CM, Georgiou CC, Snow-Harter CM, Gillis DE. Bone mineral density in mother-daughter pairs: relations to lifetime exercise, lifetime milk consumption, and calcium supplements. Am J Clin Nutr. 1996; 63: 72-9.
Tylavsky FA, Bortz AD, Hancock RL, Anderson JJ. Familial resemblance of radial bone mass between premenopausal mothers and their college-age daughters. Calcif Tissue Int. 1989; 45: 265-72.
Danielson ME, Cauley JA, Baker CE, Newman AB, Dorman JS, Towers JD, et al. Familial resemblance of bone mineral density (BMD) and calcaneal ultrasound attenuation: the BMD in mothers and daughters study, J Bone Miner Res. 1999; 14: 102-10.