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2006, Number 3

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Vet Mex 2006; 37 (3)

Immunologic importance of the N protein in the rabies virus infection

Morales-Martínez ME, Rico-Rosillo G, Gómez-Olivares JL, Aguilar-Setién A

Language: English/Spanish
References: 52
Page: 351-367
PDF size: 287.70 Kb.


ABSTRACT

Rabies is an infectious disease that attacks animals and humans. It is transmitted through the bite of an infected animal with rabies virus. Although it has lethal consequences, its structure is not very complex, it only has fi ve proteins G, N, P, L, and M2. Due to the necessity of tools to improve the effectiveness of the vaccine against rabies, this work focused on the study of N protein, that is the protein that is fi rst produced and in large quantities when new viral particles replicate. This review presents evidence of the immunologic importance, structure, and maturation of this protein. N protein must be considered to improve the immune response in vaccines against rabies.


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