Morales-Martínez ME, Rico-Rosillo G, Gómez-Olivares JL, Aguilar-Setién A

Idioma: Español/Inglés
Referencias bibliográficas: 52
Paginas: 351-367
Archivo PDF: 287.70 Kb.

RESUMEN

La rabia es una enfermedad contagiosa que ataca a animales y humanos, se transmite por la mordedura de un animal infectado con el virus de la rabia y aunque causa daño letal, su estructura no es muy compleja, pues sólo presenta cinco proteínas: G, N, P, L y M2. Dada la necesidad de contar con una herramienta para mejorar la efectividad de una vacuna contra la rabia, este trabajo se avocó al estudio de la proteína N, que es la proteína que se produce inicialmente y en mayor cantidad cuando se replican nuevas partículas virales. Esta revisión proporciona evidencia de la importancia inmunológica, estructura y maduración de esta proteína. El trabajo propone que para mejorar la respuesta inmune en las vacunas contra la rabia, se debe considerar a la proteína N.

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