2007, Number 1
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Vet Mex 2007; 38 (1)
Alterations in hemogram and selected biochemical analytes in diabetic dogs: retrospective study in 40 dogs
Jardón HSG, Mondragón VRL, Bouda J
Language: English/Spanish
References: 18
Page: 55-62
PDF size: 189.14 Kb.
ABSTRACT
The objective of this study was to describe changes in hemogram and selected biochemical analytes in blood and urine of 40 dogs with diabetes mellitus. The inclusion criteria were the following: hyperglycemia above 14 mmol/L, glucosuria and urine specifi c gravity above 1.015. Dogs of different breeds, from 4 to 14 years of age and both genders (30 females and 10 males) were studied. The analyzed diagnostic procedures were: packed cell volume, hemoglobin, red blood cell count, white blood cell count and differential cell count, Wintrobe index: mean corpuscular volume and mean corpuscular hemoglobin concentration, plasma
proteins, globulins, serum glucose, alkaline phosphatase (AP), glucosuria and specifi c gravity. Anemia was present in 47.5% of the cases, nonregenerative normocytic-normochromic anemia in 37.5%, nonregenerative normocytic-hyperchromic anemia in 5.0% and nonregenerative microcytic-normochromic anemia in 5.0%. Leukocytosis was present in 15.0% cases, leukopenia in 10.0%, neutrophilia in 47.5%, left shift in 30.0%, lymphocytosis in 5.0%, lymphopenia in 27.5%, monocytosis in 5.0%, eosinopenia
in 42.50% and eosinophilia in 10.0%. Only 10.0% of all dogs did not presented hemogram abnormalities. Alterations such as anemia, secondary infl ammation and stress, are frequent in this pathology; for which they should be considered for clinical care, prognosis and to evaluate diabetic dog’s evolution.
REFERENCES
Blaxter AC, Gruffydd-Jones TJ. Concurrent diabetes mellitus and hiperadrenocorticism in the dog. Diagnosis and management of eight cases. J Small Anim Pract 1990; 31:117-122.
Duncan JR. Veterinary laboratory medicine, clinical pathology. 2nd ed. Iowa: Iowa State University Press, 1990.
Torrance AG, Mooney CT. Manual of small animal endocrinology. 2nd ed. United Kingdom: British Small Animal Veterinary Association, 1998.
Coles EH. Veterinary clinical pathology. 4th ed. Philadelphia: W. B. Saunders, 1986.
Greco DS. Diagnosis of diabetes mellitus in cats and dogs. Vet Clin North Am Small Anim Pract 2001; 3:845-853.
Meyer DJ, Harvey JW. Laboratory in veterinary medicine. 2nd ed. Philadelphia: W. B. Saunders, 1998.
Nelson RW. Textbook of veterinary internal medicine. Diseases of the dog and cat. 4th ed. Philadelphia: W. B. Saunders, 1996.
Hoening MA, Dawe DL. Qualitative assay for beta antibodies. Preliminary results in dogs with diabetes mellitus. Vet Immunol Immunopathol 1992; 32:195-203.
Hess RS, Saqunders HM, Van Winkle TJ, Ward CR. Concurrent disorders in dogs with diabetes mellitus: 221 cases (1993-1998). J Am Vet Med Assoc 2000;217:1166-1173.
Prèlaud P, Rosenberg D, De Fornel P. Hormonal test. Functional exploration in endocrinology of domestics carnivorous. Paris: Masson-AFVAC, 2002.
Willard MD, Tvedten H, Turnwald GH. Small animal clinical diagnosis by laboratory methods. 3rd ed. Philadelphia: W. B. Saunders, 1999.
Feldman EC, Nelson RW. Endocrinology and canine and feline reproduction. Buenos Aires: Inter-Médica, 1991.
Feldman EC. Diabetes mellitus. In: Kirk RW, editor. Therapeutics veterinary clinical practice in small animals. 7th ed. México, DF: CECSA, 2000.
Voigt GL. Hematology techniques and concepts. Iowa: Iowa State University Press,2000.
Christopher MM. Hematologic complications of diabetes mellitus. Vet Clin North Am Small Anim Prac 1995;25:625-637.
Stockham SL, Scott MA. Fundamentals of veterinary clinical pathology. Iowa (USA): Iowa State Press, 2002.
Niemand HG. Canine clinic practice. México, DF: CECSA, 2004.
Mendoza RV. Diabetes mellitus in cats. Vet Vanguard 1992; 2: 27-36.