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2002, Number 4

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Ann Hepatol 2002; 1 (4)

Overview on the mechanisms of drug-induced liver cell death

Grattagliano I, Portincasa P, Palmieri VO, Palasciano G

Language: English
References: 37
Page: 162-168
PDF size: 105.73 Kb.


Text Extraction

Drug-induced hepatotoxicity is a significant and still unresolved clinical problem. The limitation in current knowledge regarding mechanisms of hepatic toxicity renders most of the preclinical review process failing and most of drug-induced hepatic injury remains unpredictable. Current knowledge on the mechanisms of drug-induced liver cell death is reviewed here. The intervention of both intra- and extracellular factors in determining the appearance of drug-induced cell apoptosis or necrosis is also discussed.
Finally, the role of both mitochondria and non parenchymal cells are reviewed with respect to approaches useful to manage drug-induced liver injury.


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