Sankar HS, Nandi S, Mallick S

Language: English
References: 31
Page: 1-13
PDF size: 1108.75 Kb.

ABSTRACT

Introduction: Surfactant in general has got significant influence on swelling and mechanical properties of hydrogel forming film, particularly used for drug delivery purposes.
Objective: The effect of surfactants on hydration and swelling, and physicomechanical behavior of the hypromellose film formulations has been studied.
Methods: Hydrogel forming films were prepared with hypromellose and different surfactants and cosurfactant systems (Croduret 40, Kolliphor HS 15, Soluplus, Transcutol HP, Captex 355, Dimethyl Sulfoxide and/or Benzalkonium chloride) using macitentan as model drug by solvent casting technique. Swelling at regular interval of time and erosion after hydration of the film formulation were estimated followed by mechanical properties such as, tensile strength, toughness etc.
Results: The highest swelling and least erosion were found in the film containing transcutol and captex (1860 and 17.43% respectively) while the film containing no surfactants/cosurfactants showed 1335 and 41.87% swelling and erosion respectively. Folding endurance of 138 and a high toughness (5.78) was found in film without surfactant where the film formulations containing surfactant/co-surfactants showed a better folding endurance and lower toughness. Elongation at break was found to be 21,30 in the case of MH where 13.80% was observed in the film containing transcutol. Tensile strength of 39.28 and 36.80 was found of the film containing transcutol and without surfactant respectively.
Conclusions: Exhibited swelling and mechanical properties were found to be the most acceptable in the Hydroxypropyl Methylcellulose film formulation containing transcutol which may be very much suitable for mucoadhesive type ocular drug delivery.

REFERENCES

1. Pramanik A, Sahoo RN, Nanda A, Pattnaik KP, Mallick S. Swelling kinetics and cornealhydration level of Kaolin in-HPMC hydrogel film. Ind J Pharm Sci. 2020 [cited12/11/2021];82(2):306-14. Available in: https://www.ijpsonline.com/articles/swellingkinetics-and-corneal-hydration-level-of-kaolininhpmc-hydrogel-film.pdf

2. Pramanik A, Sahoo RN, Nandi S, Nanda A, Mallick S. Characterization of HydrationBehaviour and Modeling of Film Formulation. Acta Chim Slov. 2021 [cited21/12/2021];68(1):159-69.

3. Nandi S, Ojha A, Nanda A, Sahoo RN, Swain R, Pattnaik KP, Mallick S. Vildagliptinplasticized hydrogel film in the control of ocular inflammation after topical application:study of hydration and erosion behaviour. Z. Phys. Chem. 2022;236(2):275-90. DOI:10.1515/zpch-2021-3081

4. Johnson BA, Kreuter J, Zografi G. Effects of surfactants and polymers on advancing andreceding contact angles. Colloids Surf. 1986;17:325-42.

5. Pattanaik S, Nandi S, Sahoo RN, Nanda A, Swain R, Das S, et al. Budesonidecyclodextrinin hydrogel system: impact of quaternary surfactant on in vitro-in vivoassessment of mucosal drug delivery. Rev Chim. 2020 [cited 12/11/2021];71:332-45.

6. Joshi SC. Sol-gel behavior of hydroxypropyl methylcellulose (HPMC) in ionic mediaincluding drug release. Materials. 2011;4(10):1861-1905.

7. Vuddanda PR, Montenegro-Nicolini M, Morales JO, Velaga S. Effect of surfactants anddrug load on physico-mechanical and dissolution properties of nanocrystalline tadalafilloadedoral films. Eur J Pharm Sci. 2017;109:372-80.

8. Roy A, Ghosh A, Datta S, Das S, Mohanraj P, Deb J, et al. Effects of plasticizers andsurfactants on the film forming properties of hydroxypropyl methylcellulose for the coatingof diclofenac sodium tablets. Saudi Pharm J. 2009;17(3):233-41.

9. Khandai S, Mithra K, Jena S. Effect of surfactants on mechanical strength ofpolyacrylamide hydrogels: A rheological study. AIP Conference Proceedings; 2017. DOI:

10. 10.1063/1.498022010. Villalobos R, Hernández-Muñoz P, Chiralt A. Effect of surfactants on water sorption andbarrier properties of hydroxypropyl methylcellulose films. Food Hydrocoll. 2006;20(4):502-9.

11. Ghadermazi R, Hamdipour S, Sadeghi K, Ghadermazi R, Khosrowshahi Asl A. Effectof various additives on the properties of the films and coatings derived from hydroxypropylmethylcellulose-A review. Food Sci. Nutr. 2019 [cited 12/11/2021];7(11):3363-77.

12. Cui W, Ji J, Cai Y-F, Li H, Ran R. Robust, anti-fatigue, and self-healing grapheneoxide/hydrophobically associated composite hydrogels and their use as recyclableadsorbents for dye waste water treatment. J Mater Chem A. 2015;3:17445-58.

13. Cui W, Zhang Z-J, Li H, Zhu L-M, Liu H, Ran R. Robust dual physically cross-linkedhydrogels with unique self-reinforcing behavior and improved dye adsorption capacity. RSCAdv. 2015;5:52966-77.

14. Jiang H, Duan L, Ren X, Gao G. Hydrophobic association hydrogels with excellentmechanical and self-healing properties Eur Polym J. 2019 [cited 14/11/2021];112:660-9.

15. Yang M, Liu C, Li Z, Gao G, Liu F. Temperature-responsive properties of poly (acrylicacid-co-acrylamide) hydrophobic association hydrogels with high mechanical strength.Macromolecules. 2010;43:10645-51.

16. Zhang Y, Zhao X, Yang W, Jiang W, Chen F, Fu, Q. Enhancement of mechanicalproperty and absorption capability of hydrophobically associated polyacrylamide hydrogelsby adding cellulose nanofiber. Mater Res Express. 2020;7(1):015319.

17. Singh NS. Effect of surfactants on polyvinyl alcohol borax hydrogel: Rheology andthermal aspects. Indian Journal of Chemistry - Section A Inorganic, Physical, Theoreticaland Analytical Chemistry. 2013;52:879-83.

18. Shamsuri A, Md. Jamil S. A Short Review on the Effect of Surfactants on the Mechanico-Thermal Properties of Polymer Nanocomposites. Appl Sci. 2020 [cited14/11/2021];10(14):4867. Available in: https://www.mdpi.com/2076-3417/10/14/4867/pdf

19. Yu J, Wei H, Dang L. Physicochemical factors affecting the mechanical properties ofsurfactant–polyvinyl alcohol hydrogel. J Disper Sci Technol. 2021;42:10, 1539-49. DOI:10.1080/01932691.2020.1774385

20. Jabir S, Sulaiman H. Preparation and characterization of lafutidine as immediate releaseoral strip using different type of water-soluble polymer. Int J App Pharm. 2018;10(5):249.DOI: https://doi.org/10.22159/ijap.2018v10i5.28292

21. Banerjee A, Ganguly S. Mechanical behaviour of alginate film with embedded voidsunder compression-decompression cycles. Sci Rep. 2019;(9):1313. DOI:https://doi.org/10.1038/s41598-019-49589-w

22. Alvarez-Lorenzo C, Concheiro A. Effects of Surfactants on Gel Behavior. American JDrug Deliv. 2003;1(2):77-101.

23. Jain S, Sandhu P S, Malvi R, Gupta B. Cellulose derivatives as thermoresponsivepolymer: an overview. J Appl Pharm Sci. 2013;3(12):139-44.

24. Lim H, Hoag SW. Plasticizer effects on physical–mechanical properties of solvent castSoluplus® films. AAPS PharmSciTech. 2013;14(3):903-10.

25. Gao P, Rush BD, Pfund WP, Huang T, Bauer J M, Morozowich W, Kuo M, HagemanM. Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel withimproved oral bioavailability. J Pharm Sci. 2003;92:2386-98.

26. Bertolini G, Feliciani L, Ferrando I, inventors; Olon SpA, assignee. Amorphous formand new crystalline forms of macitentan. United States patent application US 15/325,907.2017.

27. Zeng Y, Li S, Liu C, Gong T, Sun X, Fu Y, Zhang Z. Soluplus micelles for improvingthe oral bioavailability of scopoletin and their hypouricemic effect in vivo. Acta PharmacolSin. 2017;38: 424-33. DOI: 10.1038/aps.2016.126

28. Perioli L, Ambrogi V, Angelici F, Ricci M, Giovagnoli S, Capuccella M, et al.Development of mucoadhesive patches for buccal administration of ibuprofen. J ControlRelease. 2004;99(1):73-82.

29. Chien YW. Novel Drug Delivery Systems New York: Marcel Dekker; 1982. p. 160–161.

30. Czajkowska-Kośnik A, Sznitowska M, Mirkowska K. Self-emulsifying oils for oculardrug delivery. II. In vitro release of indomethacin and hydrocortisone. Acta Pol Pharm.2012;69(2):309-17.

31. Mura P, Corti G, Cirri M, Maestrelli F, Mennini N, Bragagni M. Development ofmucoadhesive films for buccal administration of flufenamic acid: effect of cyclodextrincomplexation. J Pharma Sci. 2010;99(7):3019-29.