2024, Number 4
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Otorrinolaringología 2024; 69 (4)
Detection of pilocytic astrocytoma in childhood through audiological symptoms and electrophysiological studies
Méndez RMR, Canales VAM, Arreola MDI, Lino GAL
Language: Spanish
References: 13
Page: 265-271
PDF size: 329.35 Kb.
ABSTRACT
Background: Pilocytic astrocytomas are tumors of the central nervous system that frequently occur in pediatric
patients (0 to 14 years). Its growth is slow and produces symptoms depending on its location. The symptoms
involved are ataxia, vomiting, headache and moderate to profound sensorineural hearing loss. Unilateral hearing
loss occurs in 46% and alterations in brainstem evoked potentials in 90% to 98% of cases. Magnetic resonance
imaging usually shows a well-defined cystic mass with an eccentric and enhancing solid nodule. There are few
reports in the literature of pilocytic astrocytoma of the cerebellopontine angle.
Clinical case: A 12-year-old female patient, in whom audiometry and brain stem auditory evoked potentials
confirmed left superficial sensorineural hearing loss and the presence of elongated latencies that, together with the
symptoms expressed by the patient, led to requesting a magnetic resonance study that showed a tumor-like lesion
in the cerebellar left hemisphere. Through biopsy analysis, a diagnosis of pilocytic astrocytoma was determined.
Conclusions: In all cases of hearing loss in pediatric patients, it is essential to conduct direct questioning
when possible.
REFERENCES
Hernández-Hernández A, López-Santaella T, Torres-Caballero A, Serrato A, et al. The transcriptomic landscapeof pediatric Astrocytoma. Int J Mol Sci 2022; 23 (20): 12696. https://doi.org/10.3390/ijms232012696
Ostrom QT, Price M, Neff C, Cioffi G, et al. CBTRUS Statistical Report: Primary brain and other centralnervous system tumors diagnosed in the United States in 2015-2019. Neuro Oncol 2022; 24 (Suppl 5): v1-v95. https://doi.org/10.1093/neuonc/noac202
Yeo KK. Astrocitomas. Manual MSD. Enero 2023. https://www.msdmanuals.com/es-mx/professional/pediatr%C3%ADa/c%C3%A1nceres-pedi%C3%A1tricos/astrocitomas
Viano JC, Herrera EJ, Suárez JC. Cerebellar astrocytomas: a 24-year experience. Childs Nerv Syst 2001;17 (10): 607-10;611. https://doi.org/10.1007/s003810100479
Palma DM, Hinojosa R, Vales HLO. Tumores del ángulo pontocerebeloso de grandes dimensiones. Posiblescausas de diagnóstico tardío. Arch Neurocien 2007; 12 (3): 166-170.
Bhradwaj P, Pandey S, Kumar P, Gupta LN, Bharadwaj M. Pilocytic astrocytoma of the cerebellopontineangle: a rare case. Egypt J Neurosurg 2022; 37: 27. https://doi.org/10.1186/s41984-022-00169-7
Mirone G, Schiabello L, Chibbaro S, Bouazza S, George B. Pediatric primary pilocytic astrocytoma of thecerebellopontine angle: a case report. Childs Nerv Syst 2009; 25 (2): 247-51. https://doi.org/10.1007/s00381-008-0690-9
Alli S, Isik S, Rutka J. Posterior fossa and brainstem tumors in children. En: Principles of NeurologicalSurgery. 4th ed. Elsevier, 2018. https://doi.org/10.1016/B978-0-323-43140-8.00011-1
González J, García-Ribes A, Axpe C. Tumores cerebrales infantiles: diagnóstico y semiología neurológica.Prot Neurol 2008; 203-209.
Otayza F. Tumores de la fosa posterior en pediatría. Rev Med Clín Condes 2017; 28 (3): 378-391.
Rajasekaran AK, Arivazhagan A, Yuvaraj P, Shivashankar N. Audiovestibular findings in a 6 year old childwith pilocytic astrocytoma - a case report. Int J Audiol 2020; 59 (3): 236-241. https://doi.org/10.1080/14992027.2019.1697466
Fleming AJ, Chi SN. Brain tumors in children. Curr Probl Pediatr Adolesc Health Care 2012; 42 (4): 80-103.https://doi.org/10.1016/j.cppeds.2011.12.002
Villarejo F, Martínez-Laje JF. Tumores cerebrales en niños. Pediatr Integral 2012; 16 (6): 475-486