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2022, Number 3

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Rev Cubana Cardiol Cir Cardiovasc 2022; 28 (3)

Neutrophil-lymphocyte index as inflammatory biomarker and potential predictor of atherosclerotic cardiovascular disease risk

Rodríguez PJM

Language: Spanish
References: 61
Page: 1-8
PDF size: 393.13 Kb.


ABSTRACT

Introduction: Atherosclerosis and the associated inflammatory processes have a direct influence on the neutrophil-lymphocyte ratio. This is an auxiliary tool that contributes to stratify patients by the different risk categories of developing cardiovascular diseases.
Objective: To analyze the role of neutrophil-lymphocyte index as inflammatory biomarker and potential predictor of atherosclerotic cardiovascular disease risk.
Methods: Bibliographic search was carried out in PubMed, SciELO, LILACS, CUMED, and HINARI databases from March to August 2021. The units of analysis included original articles, review articles (systematic or metaanalysis review), published in Spanish and English. Odd ratios were extracted with a confidence interval of 95 % for short- and long-term mortality, and the incidence risk of clinical events and complications. A funnel chart is used to illustrate the unbiased and symmetrical distribution of the publication.
Results: Evidence shows that the inflammatory response triggered by atherosclerosis correlates positively with the increase in the basal levels of the neutrophil-lymphocyte index and with a higher risk of mortality by atherosclerotic cardiovascular disease. The neutrophil-lymphocyte ratio is an available inflammatory biomarker that can predict fatal and non-fatal cardiovascular events in patients with coronary artery disease, cerebrovascular disease, chronic kidney disease, or lower extremities arteries disease.
Conclusions: The neutrophil-lymphocyte index is an inflammatory biomarker and a potential predictor of the atherosclerotic cardiovascular disease risk.


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