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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2003, Number 1

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An Med Asoc Med Hosp ABC 2003; 48 (1)

Lidocaine and clonidine influence on sevoflurane, desflurane and fentanyl requirements during balanced general anesthesia

Acevedo RPE, Revilla PF, Cendón OMM

Language: Spanish
References: 18
Page: 38-41
PDF size: 49.31 Kb.


ABSTRACT

Clonidine an alpha 2 agonist and lidocaine an amide local anesthetic, were evaluated as useful clinic adjuvants during anesthesia. Material and methods: 90 ASA I–II patients divided in six groups were evaluated for balanced anesthesia: Control groups I and IV, under sevoflurane or desflurane and fentanyl transanesthetic maintenance; groups II and V, with same transanesthetic maintenance plus lidocaine intravenous infusion at 2.3 mg/kg/h; groups III and VI, with initial anesthetic treatment, but with 4 mg/kg clonidine intravenous pre-anesthetic medication. Induction of anesthesia with 2 mg/kg fentanyl, 2 mg/kg propofol, and 600 mg/kg rocuronium for orotracheal intubation. The intake of sevoflurane, desflurane and fentanyl were determined. Hemodynamic parameters, partial oxygen saturation, and carbon dioxide at the end of the expiration were monitored. T Student analysis was used. Results: The decrease in the intake of sevoflurane for lidocaine and clonidine was significant with a stronger additive effect for lidocaine. The intake of fentanyl decreased significantly, but with no difference between groups. The intake of desflurane associated with clonidine decreased significantly compared with the intake associated with lidocaine. The intake of fentanyl associated with desflurane and clonidine decreased significantly. Conclusion: Lidocaine and clonidine as adjuvants in balanced anesthesia with sevoflurane or desflurane do not present collateral effects. A major additive synergetic effect was observed for lidocaine + sevoflurane and clonidine + desflurane.


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