2003, Número 1
<< Anterior Siguiente >>
An Med Asoc Med Hosp ABC 2003; 48 (1)
Resistencia a antibióticos, problema de salud pública
Rivera-Tapia JA
Idioma: Ingles.
Referencias bibliográficas: 50
Paginas: 42-47
Archivo PDF: 61.53 Kb.
RESUMEN
La resistencia a antibióticos representa uno de los principales problemas de la población en lo referente a salud pública y a la práctica clínica. Esto es debido al incesante incremento en el uso de antibióticos durante los últimos 50 años, además de que las bacterias resistentes a los antibióticos se han propagado de forma abrumadora. Es importante señalar que hace tiempo los antibióticos participan activamente en la selección de bacterias resistentes sin olvidar que la velocidad con la que aparecen genes de resistencia también contribuyen a dicho problema. La selección de microorganismos resistentes puede ocurrir durante o después de tratamientos con antimicrobianos, los residuos de antibióticos pueden establecerse en el ambiente durante periodos de tiempo considerables posterior al tratamiento. De forma paralela al uso de los antibióticos se presenta el empleo de otros agentes que se proponen para eliminar bacterias, como es el uso de bactericidas ahora disponibles en algunos productos domésticos. Estos últimos también tienen la capacidad de permanecer en el ambiente, participando en la dinámica de la ecología microbiana, en lo referente a resistencia contra la susceptibilidad bacteriana y en la supervivencia de diversos grupos de microorganismos.
REFERENCIAS (EN ESTE ARTÍCULO)
Livermore DM. b-lactamases in laboratory and clinical resistance. Clin Microbiol Rev 1995; 8: 557-584.
Barriga AG, Rojas ML, Peredo LVM. Actualidades en los patrones de resistencia a los antimicrobianos. Rev Mex Patol Clin 2001; 48: 65-69.
Chopra J, Hawkey PM, Hinton M. Tetracyclines, molecular and clinical aspects. J Antimicrob Chemother 1992; 29: 247-277.
Tomasz A, Munoz R. b-lactam antibiotic resistance in Gram positive bacteria pathogens of the upper respiratory ttract: a brief overview of mechanisms. Microbiol Drug Resistance 1995; 1: 103-109.
Garcia-Bustos J, Tomasz A. A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci. Proc Natl Acad Sci USA 1990; 87: 5415-5419.
Michel M, Gutmann L. Methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci: therapeutic realities and possibilities. Lancet 1997; 349: 1901-1906.
Leclercq R, Courvalin P. Resistance to glycopeptides in enterococci. Clin Infect Dis 1997; 24: 545-556.
Craig WA. Temas del futuro de la resistencia antimicrobiana. Enf Infec Micro 2000; 20: 172-177.
Levy SB. Factors impacting on the problem of antibiotic resistance. J Antimicrob Chemother 2002; 49: 25-30.
Cohen ML. Epidemiology of drugs resistance: implications for a post-antimicrobial era. Science 1992; 257: 1050-1055.
Vincent JL, Bihari DJ, Suter PM, Bruining HA, White J, Nicolas-Chanoine MH et al. The prevalence of nosocomial infection in intensive care units in Europe. JAMA 1995; 274: 639-644.
Vandenbroucke-Grauls C. Management of methicillin-resistant Staphylococcus aureus in the Netherlands. Rev Med Microbiol 1998; 9: 109-116.
Mulligan ME, Murray-Leisure KA, Ribner BS, Standiford HC, John JF, Korvick JA et al. Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis and epidemiology with implications for prevention and management. Am J Med 1993; 94: 313-328.
Gold HS, Moellering RC. Antimicrobial-drug resistance. N Engl J Med 1996; 335: 1445-1453.
Livermore DM, Yuan M. Antibiotic resistance and production of extended-sprectrum b-lactamases amongst Klebsiella spp from intensive care units in Europe. J Antimicrob Chemother 1996; 38: 409-424.
Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Jonhson MP et al. Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med 1991; 115: 585-590.
De Cheldre Y, Maes N, Rost F, De Ryck R,Clevenbergh P, Vincent JL et al. Molecular epidemiology of an outbreak of multidrug-resistant Enterobacter aerogenes infections and in vivo emergence of imipenem resistance. J Clin Microbiol 1997; 35: 152-160.
Towner KJ. Clinical importance and antibiotic resistance of Acinetobacter spp. J Med Microbiol 1997; 46: 721-746.
Struelens MJ, Carlier E, Maes N, Serruys E, Quint WGV, van Belkum A. Nosocomial colonization and infection with multiresistant Acinetobacter baumannii: Outbreak delineation using DNA macrorestriction analysis and PCR-fingerprinting. J Hosp Infect 1993; 25: 15-32.
McGowan JE. Antimicrobial resistance in hospital organisms and its relation to antibiotic use. J Infect Dis 1983; 5: 1033-1048.
Davies JE. Origins, acquisition and dissemination of antibiotic resistance determinants. Ciba Found Symp 1997; 207: 15-27.
Fluit AdC, Visser MR, Schmitz FJ. Molecular detection of antimicrobial resistance. Clin Microbiol Rev 2001; 14: 836-871.
Lederberg J, Lederberg EM. Replica plating and indirect selection of bacterial mutants. J Bacteriol 1952; 63: 399-406.
Luria SE, Delbruck M. Mutations of bacteria from virus sensitivity to virus resistance. Genetics 1943; 28: 491-511
Hopper DC. Mechanisms of fluoroquinolone resistance. Drug Resis Updates 1999; 2: 38-55.
Martinez JL, Alonso A, Gomez-Gomez JM, Baquero F. Quinolone resistance by mutations in chromosomal gyrase genes. Just the tip of the iceberg? J Antimicrob Chemother 1998; 42: 683-688.
Figueiredo AM, Ha E, Kreiswirth BN, Lencastre de H, Noel GJ, Senterfit L, Tomasz A. In vitro stability of heterogeneous expression classes in clinical isolates of methicillin-resistant staphylococci. J Infect Dis 1991; 164: 883-887.
Kohler T, Michea-Hamzehpour M, Plesiat P, Kahr AL, Pechere JC. Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa. Antimicrob Agents Chemother 1997; 41: 2540-2543.
Hughes D, Andersson DI. Carbon starvation of Salmonella typhimurium does not cause a general increase of mutation rates. J Bacteriol 1997; 179: 6688-6691.
Foster PL. Adaptive mutation: the uses of adversity. Annu Rev Microbiol 1993; 47: 467-504.
Shapiro JA. Genome organization, natural genetic engineering and adaptive mutation. Trends Genet 1997; 13: 98-104.
LeClerc JE, Li B, Payne WL, Cebula TA. High mutation frequencies among Escherichia coli and Salmonella pathogens. Science 1996; 274: 1208-1211.
Taddei F, Radman M, Maynard-Smith J, Toupance B, Gouyon PH, Godelle B. Role of mutator alleles in adaptative evolution. Nature 1997; 387: 700-702.
Mamber SW, Kolek B, Brookshire KW, Bonner DP, Fung-Tomc J. Activity of quinolones in the Ames Salmonella TA102 mutagenicity test and other bacterial genotoxicity assays. Antimicrob Agents Chemother 1993; 37: 213-217.
Ren L, Rahman MS, Humayun MZ. Escherichia coli cells exposed to streptomycin display a mutator phenotype. J Bacteriol 1999; 181: 1043-1044.
Fish DN, Piscitelli SC, Danzinger LH. Development of resistance during antimicrobial therapy: A review of antibiotic classes and patient characteristics in 173 studies. Pharmacotherapy 1995; 15: 279-291.
Kristinsson KG, Hijalmarsdottir M, Steingrimsson O. Increasing penicillin resistance in pneumococci in Iceland. Lancet 1992; 399: 1606-1607.
Ekdahl K, Cars O. Role of communicable disease control measures in affecting the spread of resistant pneumococci the Swedish model. Clin Microbiol Infect 1998; 5 (suppl 4): S48-54.
Tomasz A. The challenge of multiresistant Streptococcus pneumoniae: international initiatives in day-care centers and the use of molecular epidemiologic techniques. Clin Microbiol Infect 1998; 5, (suppl 4): S64-68.
Davies J. Inactivation of antibiotics and the dissemination of resistance genes. Science 1994; 264: 375-382.
Houndt T, Ochman H. Long-term shifts in patterns of antibiotic resistance in enteric bacteria. Appl Envir Microbiol 2000; 66: 5406-5409.
Grahn E, Holm SE. Penicillin concentration in saliva and its influence on bacterial interference. Scan J Infect Dis 1987; 19: 235-241.
Nord CE, Heimdahl A, Kager L. Antimicrobial induced alterations of the human oropharyngeal and intestinal microflora. Scand J Infect Dis 1986; 49: 64-72.
Spratt BG. Resistance to antibiotic mediated by target alterations. Science 1994; 264: 388-393.
Edlund C, Nord CE. Ecological impact of antimicrobial agents on human intestinal microflora. Alpe Adria Microbiol J 1993; 3: 137-164.
Hoiby N, Johansen HK. Ciprofloxacin in sweat and antibiotic resistance. The Copenhagen Study Group on Antibiotics in Sweat. Lancet 1995; 346: 1235.
Hoiby N, Jarlov JO, Kemp M, Tvede M, Bangsborg JM, Kjerulf A et al. Excretion of ciprofloxacin in sweat and multiresistant Staphylococcus epidermidis. Lancet 1997; 349: 167-169.
Gahm-Hansen B. Coagulase-negative staphylococci and micrococci in clinical microbiology. Danish Med Bulletin 1987; 34: 96-114.
Jarlov JO, Hoiby N. Coagulase-negative staphylococci in a major Danish university hospital: diversity in antibiotic susceptibility between wards. Act Path Microbiol Immun Scan 1998; 106: 411-416.
Rodríguez RS, Calderón JE, Gómez BD, Espinosa ML. Características de la resistencia antimicrobiana de una colección clínica de Streptococcus pyogenes. Sal Pub Mex 2000; 42: 226-229.