Gómez RAP, Gómez RDR, Innes GX, Márquez RA, González SEA, Dorantes AA

Language: Spanish
References: 15
Page: 392-398
PDF size: 339.20 Kb.

ABSTRACT

A case of posterior cortical atrophy (ACP) is presented, supplemented by a literature review describing the neurodegenerative phenomenon that evolves due to decreased neuronal tissue at the cortical level, characterized by symptoms indicating perceptual agnosia. The findings focused on alpha-synuclein (AS) and its role in PCA. The results suggest that AS has presynaptic physiological functions, but its aggregation leads to the formation of amyloid fibrils, interaction with beta-amyloid and tau, and neuronal inclusion. This activates microglia, triggering chronic inflammation, oxidative stress, and neuronal death. In addition, AS alters cellular mechanisms such as autophagy. In conclusion, the abnormal aggregation of AS is a determining factor in the pathophysiology of PCA by inducing neurotoxicity, neuroinflammation, autophagic dysfunction, and synergy with other altered proteins, resulting in evident cortical atrophy, as demonstrated in the brain dissection.

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