medigraphic.com
Organo Oficial de la Sociedad Mexicana de Urología

2024, Number 4

<< Back Next >>

Rev Mex Urol 2024; 84 (4)

Pancreatic resection for metastatic renal cell cancer: experience of a high-volume Mexican hospital

García-Castillo EC, Rodríguez-Covarrubias FT, Santes-Jasso Ó, Tena-González MG

Language: Spanish
References: 28
Page: 1-10
PDF size: 216.13 Kb.


ABSTRACT

Objective: The aim of our study was to report the oncological and surgical outcomes of the pancreatic resections due to solitary pancreatic metastasis of RCC in a tertiary care reference center for pancreatic masses in Mexico.
Materials y methods: All pancreatic resections at our Institution from 2002 to 2022 were retrospectively analyzed. We only included patients treated with pancreatic resections due to metastatic RCC to the pancreas. We evaluated symptoms, time from nephrectomy to pancreatic resection, type of surgery, complications and oncological outcomes.
Results: Eight pancreatic resections due to solitary metastases of RCC were performed. The median age of presentation was 69 years. The most prevalent symptom was abdominal pain (50 %). 6 pancreatoduodenectomies (Whipple procedure), 1 distal pancreatectomy and 1 total pancreatomy were done. The median time between radical nephrectomy and pancreatic resection was 122 months (8-247 months). Seven had negative surgical margins. The median follow- up time after pancreatic surgery was 42 months (1-109 months). The only case that died had pulmonary metastases and the resection was R1. Originality and value: Original study demonstrating the survival outcomes of pancreatic resection for metastatic renal cell carcinoma in a high-volume hospital in Mexico.
Limitations: Retrospective study and the limited number of cases.
Conclusions: Pancreatic resections due to solitary metastases from CCR could offer some advantages on survival, as long as they are done in high volume centers.


REFERENCES

  1. Siegel Rl, Miller Kd, Jemal A. Cancer statistics, 2019. CA: a cancer journal forclinicians. 2019;69(1). https://doi.org/10.3322/caac.21551.

  2. International Agency for Research on Cancer.Global Cancer Observatory: Cancer Today,México. 2022 p. 2.

  3. Siegel Rl, Miller Kd, Jemal A. Cancer statistics,2020. CA: a cancer journal for clinicians.2020;70(1). https://doi.org/10.3322/caac.21590.

  4. Ljungberg B, Campbell Sc, Choi Hy, JacqminD, Lee Je, Weikert S, et al. The epidemiologyof renal cell carcinoma. European urology.2011;60(4). https://doi.org/10.1016/j.eururo.2011.06.049.

  5. Janzen Nk, Kim Hl, Figlin Ra, Belldegrun As.Surveillance after radical or partial nephrectomyfor localized renal cell carcinoma andmanagement of recurrent disease. The Urologicclinics of North America. 2003;30(4). https://doi.org/10.1016/s0094-0143(03)00056-9.

  6. Bianchi M, Sun M, Jeldres C, Shariat Sf, TrinhQd, A B, et al. Distribution of metastatic sites inrenal cell carcinoma: a population-based analysis.Annals of oncology : official journal of the EuropeanSociety for Medical Oncology. 2012;23(4). https://doi.org/10.1093/annonc/mdr362.

  7. Scatarige Jc, Horton Km, Sheth S, FishmanEk. Pancreatic parenchymal metastases:observations on helical CT. AJR. Americanjournal of roentgenology. 2001;176(3). https://doi.org/10.2214/ajr.176.3.1760695.

  8. Ascenti G, Visalli C, Genitori A, Certo A,Pitrone A, Mazziotti S. Multiple hypervascularpancreatic metastases from renal cell carcinoma:dynamic MR and spiral CT in three cases. Clinicalimaging. 2004;28(5). https://doi.org/10.1016/S0899-7071(03)00198-0.

  9. Law Ch, Wei Ac, Hanna Ss, Al-Zahrani M,Taylor Br, Pd G, et al. Pancreatic resection formetastatic renal cell carcinoma: presentation,treatment, and outcome. Annals of surgicaloncology. 2003;10(8). https://doi.org/10.1245/aso.2003.02.003.

  10. Kassabian A, Stein J, Jabbour N, Parsa K,Skinner D, D P, et al. Renal cell carcinomametastatic to the pancreas: a single-institutionseries and review of the literature. Urology.2000;56(2). https://doi.org/10.1016/s0090-4295(00)00639-7.

  11. Bassi C, Butturini G, Falconi M, Sargenti M,Mantovani W, Pederzoli P. High recurrencerate after atypical resection for pancreaticmetastases from renal cell carcinoma. TheBritish journal of surgery. 2003;90(5). https://doi.org/10.1002/bjs.4072.

  12. Miura T, Nakamura N, Ogawa K, Watanabe Y,Yonekura K, T S, et al. [Resection of PancreaticMetastasis from Renal Cell Carcinoma 21 Yearsafter Nephrectomy]. Gan to kagaku ryoho.Cancer & chemotherapy. 2016;43(12). https://pubmed.ncbi.nlm.nih.gov/28133264/

  13. Kato D, Abe Y, Nishihara K, Katsumoto F,Tamae K, Mitsuyama S. Pancreatic metastasisfrom renal cell carcinoma 13 years after anephrectomy: report of a case. Internationalsurgery. 2007;92(4). https://pubmed.ncbi.nlm.nih.gov/18050834/

  14. Faure Jp, Tuech Jj, Richer Jp, Pessaux P, ArnaudJp, Carretier M. Pancreatic metastasis of renalcell carcinoma: presentation, treatment andsurvival. The Journal of urology. 2001;165(1).ht t p s : //doi . org/10.1097/00005392-200101000-00005

  15. Hirota T, Tomida T, Iwasa M, Takahashi K,Kaneda M, Tamaki H. Solitary pancreaticmetastasis occurring eight years afternephrectomy for renal cell carcinoma. Acase report and surgical review. Internationaljournal of pancreatology : official journal of theInternational Association of Pancreatology.1996;19(2). https://doi.org/10.1007/BF02805229.

  16. Thompson Ld, Heffess Cs. Renal cellcarcinoma to the pancreas in surgical pathologymaterial. Cancer. 2000;89(5). https://doi.org/10.1002/1097-0142(20000901)89:5<1076::aid-cncr17>3.0.co;2-m.

  17. Vilar Tabanera A, Muñoz Muñoz P, MolinaVillar JM, Gajate P, Sanjuanbenito A. Surgery ofpancreatic metastasis from renal cell carcinoma.Cirugia Espanola. 2022;100(1): 50–52. https://doi.org/10.1016/j.cireng.2021.11.005.

  18. Grassi P, Doucet L, Giglione P, GrünwaldV, Melichar B, Galli L, et al. Clinical Impactof Pancreatic Metastases from Renal CellCarcinoma: A Multicenter RetrospectiveAnalysis. PLoS ONE. 2016;11(4): e0151662.https://doi.org/10.1371/journal.pone.0151662.

  19. Showalter SL, Hager E, Yeo CJ. Metastaticdisease to the pancreas and spleen. Seminarsin Oncology. 2008;35(2): 160–171. https://doi.org/10.1053/j.seminoncol.2007.12.008.

  20. Sperti C, Moletta L, Patanè G. Metastatic tumorsto the pancreas: The role of surgery. Worldjournal of gastrointestinal oncology. 2014;6(10).https://doi.org/10.4251/wjgo.v6.i10.381.

  21. Sellner F. Isolated pancreatic metastases fromrenal cell carcinoma: an outcome of a specialmetastatic pathway or of specific tumor cellselection? Clinical & experimental metastasis.2018;35(3). https://doi.org/10.1007/s10585-018-9910-1.

  22. Cheng SKH, Chuah KL. Metastatic Renal CellCarcinoma to the Pancreas: A Review. Archivesof Pathology & Laboratory Medicine. 2016;140(6):598–602. https://doi.org/10.5858/arpa.2015-0135-RS.

  23. Schwarz L, Sauvanet A, Regenet N, MabrutJY, Gigot JF, Housseau E, et al. Long-termsurvival after pancreatic resection for renalcell carcinoma metastasis. Annals of SurgicalOncology. 2014;21(12): 4007–4013. https://doi.org/10.1245/s10434-014-3821-4.

  24. Mikhail M, Chua KJ, Khizir L, Tabakin A, SingerEA. Role of metastasectomy in the managementof renal cell carcinoma. Frontiers in Surgery.2022;9: 943604. https://doi.org/10.3389/fsurg.2022.943604.

  25. Sellner F, Tykalsky N, De Santis M, Pont J,Klimpfinger M. Solitary and multiple isolatedmetastases of clear cell renal carcinoma to thepancreas: an indication for pancreatic surgery.Annals of surgical oncology. 2006;13(1). https://doi.org/10.1245/ASO.2006.03.064.

  26. Tanis Pj, van der Gaag Na, Busch Or, van GulikTm, Gouma Dj. Systematic review of pancreaticsurgery for metastatic renal cell carcinoma. TheBritish journal of surgery. 2009;96(6). https://doi.org/10.1002/bjs.6606.

  27. Boni A, Cochetti G, Ascani S, Del ZingaroM, Quadrini F, Paladini A, et al. Robotictreatment of oligometastatic kidney tumor withsynchronous pancreatic metastasis: case reportand review of the literature. BMC Surgery.2018;18: 40. https://doi.org/10.1186/s12893-018-0371-x.

  28. Jo S, Yang IJ, Song S. Surgery for metastatic renalcell carcinoma in the pancreatic head: A casereport and literature review. Annals of Hepato-Biliary-Pancreatic Surgery. 2019;23(1): 91.https://doi.org/10.14701/ahbps.2019.23.1.91.




2020     |     www.medigraphic.com