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2024, Number 3

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Rev Educ Bioquimica 2024; 43 (3)

TRIM25: un regulador transcripcional, postranscripcional y postraduccional desregulado en cáncer

Palacios-Serrato EG, Medina-Abreu KH, Oropeza-Martínez E, Macías-Silva M, Tecalco-Cruz ÁC

Language: Spanish
References: 87
Page: 151-165
PDF size: 725.14 Kb.


ABSTRACT

The protein family containing tripartite motif (TRIM) is involved in several cellular processes because of its functional versatility due to its different domains. TRIM proteins are mainly characterized by their enzymatic function as E3-ubiquitin ligases. TRIM25 is a member of the TRIM protein family that acts as E3-ubiquitin ligase and E3 ligase for ISG15 in a post-translational process known as ISGylation. Moreover, TRIM25 can associate with DNA and RNA and modulate gene expression at transcriptional and posttranscriptional levels. In this paper, we review the characteristics of TRIM25 and the relevance of its multifunctionality in cancer development and progression.


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