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2024, Number 2

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rev homeostasis 2024; 6 (2)

SARS-CoV-2 y su papel potencial en la patogénesis del Síndrome de Guillain-Barré

Guzmán-Castellanos JF, Tamayo-Escorcia EA, Méndez-Cruz N, Martínez-Medina S

Language: Spanish
References: 59
Page:
PDF size: 250.51 Kb.


ABSTRACT

The recent pandemic caused by the novel coronavirus has generated significant uncertainty in the medical field. Although the majority of patients experience infection with the SARS-CoV-2 virus through the respiratory system, a significant percentage also present with nonspecific neurological manifestations such as headache, inattention, paresthesia, and anosmia. An increased risk of developing Guillain-Barré Syndrome (GBS), an acute polyradiculoneuropathy with typical post infectious presentation, has been observed in individuals infected by the aforementioned virus. Despite cases linking these two diseases being reported since early 2020, the pathogenesis remains a subject of controversy. The most accepted theories include complement system activation, excessive release of proinflammatory cytokines, molecular mimicry, generation of free radicals through oxidative stress pathways, dysfunction of the blood-brain barrier, and post-vaccination reaction. Additionally, it has been suggested that GBS could be another manifestation of the post-COVID-19 syndrome. This narrative literature review aims to present the primary pathophysiological theories of this causal relationship to date.


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