2024, Number 8
<< Back Next >>
Med Int Mex 2024; 40 (8)
COVID-19 mRNA-based vaccines: qu’est-ce que c’est?
Mercado U
Language: Spanish
References: 8
Page: 531-534
PDF size: 268.51 Kb.
ABSTRACT
An outbreak of atypical pneumonia emerged towards the end of December 2019 in
the city of Wuhan, China, which became a pandemic. A new coronavirus (SARS-CoV-2
or COVID-19) was identified as the causative agent and the viral genome sequence
was obtained in the first week of January 2020. In general, coronaviruses contain
a single strand of ribonucleic acid (RNA) of positive polarity, which is identical to
the messenger RNA that carries the DNA instructions to the ribosomes for protein
synthesis. The viral genome encodes 4 structural proteins (M, E, N and S), of which
the S (spike) protein binds to the ACE-2 receptor to enter the cell cytoplasm. When
RNA encoding protein S encapsulated in lipid nanoparticles is injected, cells will
take it up and produce the protein in large quantities (1000 to 100,000 proteins). The
S protein is the target of the COVID-19 mRNA based-vaccines to generate immune
response with › 90% efficacy.
REFERENCES
Jarcho JA, Ingelfinger JR, Hamel MB, D’Agostino RB, HarringtonDP. Editorial. Inhibitors of the renin-angiotensinaldosteronesystem and Covid-19. N Engl J Med 2020; 382: 2462-64. DOI: 10.1056/NEJMe2012924
Ruiz-Bravo A, Jiménez-Valera M. SARS-CoV-2 y pandemia desíndrome respiratorio agudo (COVID-19). Ars Pharm 2020;61: 1-29. https://dx.doi.org/10.30827/ars.v61i2.15177
Pastrian SG. Presencia y expresión del receptor ACE2(target de SARS-CoV-2) en tejidos humanos y cavidad oral.Posibles rutas de infección en órganos orales. Int J Odontostomat2020; 14: 501-507. http://dx.doi.org/10.4067/S0718-381X2020000400501
Rabi FA, Al Zoubi MS, Kasasbeeh GA, Salameh DM, Al-Nasser AD. SARS-CoV-2 and coronavirus disease 2019:what we know so far. Pathogens 2020; 9: 231. doi: 10.3390/pathogens9030231
Hu B, Guo H, Zhou P, Li-Shi Z. Characteristics of SARS-CoV-2and COVID-19. Nat Rev Microbiol 2021; 19: 141-154. doi:10.1038/s41579-020-00459-7
Li W, Moore MJ, Vasilleva N, Sul H, et al. Angiotensin-convertingenzyme 2 is a functional receptor for the SARS coronavirus.Nature 2003; 426: 450-54. doi: 10.1038/nature02145
Weissman D. Messenger RNA therapies finally arrived.Scientific American 2022; 326 (3): 54-55.
Li W, Moore MJ, Vasilleva N, Sul H, et al. Angiotensinconvertingenzyme 2 is a functional receptor for the SARScoronavirus. Nature 2003; 426: 450-54. doi: 10.1038/nature02145
Full text