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2023, Number 4

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Rev Hematol Mex 2023; 24 (4)

Leukemia cutis in a patient with leukemialymphoblastic lymphoma B

Cetina CGC, Fernández VOE, Avilés SA, Urbalejo CVI

Language: Spanish
References: 25
Page: 220-225
PDF size: 295.85 Kb.


ABSTRACT

Background: Leukemia cutis refers to skin involvement (dermis, epidermis, or subcutaneous tissues) by neoplastic leukocytes or their immature forms. It is more frequent in acute myeloid leukemia and acute lymphoblastic leukemia/lymphoma (ALL) of T lineage, being infrequent in B-ALL, with few case reports in the literature and limited known clinical evolution.
Clinical case: A 20-year-old male patient whose initial clinical presentation was leukemia cutis.
Conclusions: Leukemia cutis as a presenting sign of B-ALL is infrequent, with scant information and indeterminate clinical course. Limited and indirect evidence suggests a physiopathogenic basis, nonetheless, recognition of this rare presentation is important in the early detection of hematologic malignancies with extramedular infiltration.


REFERENCES

  1. Bontoux C, De Masson A, Boccara O, Bodemer C, etal, Outcome and clinicophenotypical features of acutelymphoblastic leukemia/lymphoblastic lymphoma withcutaneous involvement: A multicenter case series. J AmAcad Dermatol 2020; 83 (4): P1166-1170.

  2. Bay A, Faik A, Tuncer O, Atas B, et al. Acute lymphoblasticleukemia presenting with cutaneous involvement. Eur JGen Med 2004; 1 (2): 46-47.

  3. Wagner G, Fenchel K, Back W, Schulz A, Sachse MM.Leukemia cutis - epidemiology, clinical presentation, anddifferential diagnoses. J Dtsch Dermatol Ges 2012; 10: 27-36. doi: 10.1111/j.1610-0387.2011.07842.x.

  4. Su WPD, Buechner SA, Li CY. Clinicopatologic correlationsin leukemia cutis. J Am Acad Dermatol 1984; 11: 121-128.doi: 10.1016/s0190-9622(84)70145-9.

  5. Li L, Wang Y, Lian CG, Hu N, Jin H, Liu Y. Clinical and pathologicalfeatures of myeloid leukemia cutis. An Bras Dermatol2018; 93: 216-221. doi: 10.1590/abd1806-4841.20186327.

  6. Wang S-M, Park S-S, Park S-H, Kim N-Y, Kang DW, Na H-R,et al. Pre-transplant depression decreased overall survivalof patients receiving allogeneic hematopoietic stem celltransplantation: a nationwide cohort study. Sci Rep 2020;10: 1-10. https://doi.org/10.1038/s41598-020-71208-2.

  7. Peña-Romero AG, Domínguez-Cherit J, Méndez-Flores S.Leukemia cutis: clinical features of 27 Mexican patients anda review of the literature. Gac Med Mex 2016; 152: 629-35.

  8. Jiang X, Wang W, Zhang M. Leukemia cutis: an unusual presentationof acute lymphoblastic leukemia in a child. IndianJ Dermatol 2015; 60: 636. doi: 10.4103/0019-5154.169153.

  9. Chien AJ, Argenyi ZB, Colven RM, Kirby P. Acute lymphoblasticleukemia presenting with urticarial plaques andhypereosinophilia in a child. J Am Acad Dermatol 2004; 51Suppl: S151-5. doi: 10.1016/j.jaad.2004.04.018.

  10. Bakhshi S, Sethuraman G, Singh MK and Arya LS. Atypicalpyoderma gangrenosum as a man- ifestation of childhoodacute lymphoblastic leukemia. Pediatr Dermatol 2005; 22:543- 545. doi: 10.1111/j.1525-1470.2005.00136.x.

  11. Anderson PC, Stotland MA, Dinulos JG, Perry AE. Acutelymphocytic leukemia presenting as an isolated scalp nodulein an infant. Ann Plast Surg 2010; 64: 251-253. doi:10.1097/SAP.0b013e3181a5b5fe.

  12. Jaing TH, Hsueh C, Chiu CH, Shih IH, Chan CK, Hung IJ.Cutaneous lymphocytic vasculitis as the presenting featureof acute lymphoblastic leukemia. J Pediatr Hematol Oncol2002; 24: 555-557. doi: 10.1097/00043426-200210000-00012.

  13. Ramakrishnan PG, Hoffmann MS, Pemmaraju N, Hu S, etal. Extramedullary B lymphoblastic leukemia/lymphoma(B-ALL/LBL): A diagnostic challenge. Clin LymphomaMyeloma Leuk 2014; 14 (4): e115-e118. doi: 10.1016/j.clml.2014.01.004.

  14. Afzal A, Mingola P, Farooque U, Shabih S, et al. B-cell acutelymphoblastic leukemia presenting as leukemia cutis: Acase report. Cureus 2020; 12 (10): e11032. DOI: 10.7759/cureus.11032

  15. Shafer D, Wu H, Al-Saleem T, Reddy K, et al. Cutaneousprecursor B-cell lymphoblastic lymphoma in 2 adult patients:clinicopathologic and molecular cytogenetic studieswith a review of the literature. Arch Dermatol 2008; 144(9): 1155-62.

  16. Lin P, Jones D, Dorfman DM, Medeiros LJ. Precursor B-celllymphoblastic lymphoma: a predominantly extranodaltumor with low propensity for leukemic involvement.The Am J Surg Pathol 2000; 24 (11): 1480-90. doi:10.1097/00000478-200011000-00003.

  17. Maitra A, McKenna RW, Weinberg AG, Schneider NR, KroftSH. Precursor B-cell lymphoblastic lymphoma. A study ofnine cases lacking blood and bone marrow involvementand review of the literature. Am J Clin Pathol 2001; 115 (6):868-75. doi: 10.1309/Q5GV-3K00-WAC6-BBUB.

  18. Hwa Jung Yook, Joon Ho Son, Yeong Ho Kim, Ju Hee Han, etal. Leukaemia cutis: Clinical features and outcomes of 56patients. Acta Derm Venereol 2022; 102: adv00647. doi:10.2340/actadv.v102.1123.

  19. Crazzolara R, Kreczy A, Mann G, Heitger A, et al. Highexpression of the chemokine receptor CXCR4 predictsextramedullary organ infiltration in childhood acute lymphoblasticleukaemia. Br J Haematol 2001; 115 (3): 545-53.doi: 10.1046/j.1365-2141.2001.03164.x.

  20. Guo R, Chai L, Chen L, Chen W, et al. Stromal cell-derivedfactor 1 (SDF-1) accelerated skin wound healing by promotingthe migration and proliferation of epidermal stemcells. In Vitro Cell Dev Biol Anim 2015; 51 (6): 578-85. doi:10.1007/s11626-014-9862-y.

  21. Nishiguchi MA, Spencer CA, Leung DH, Leung TH. Agingsuppresses skin-derived circulating SDF1 to promote fullthicknesstissue regeneration. Cell Rep 2018; 24: 3383-3392. doi: 10.1016/j.celrep.2018.08.054.

  22. Tashiro K, Tada H, Heikler R, Shirozu M, Nakano T, HonjoT. Signal sequence trap: a cloning strategy for secretedproteins and type I membrane proteins. Science 1993; 261:600-603. doi: 10.1126/science.8342023.

  23. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, Littman DR.Function of the chemokine receptor CXCR4 in haematopoiesisand in cerebellar development. Nature 1998; 393:595-99. doi: 10.1038/31269.

  24. Watson KM, Mufti G, Salisbury JR, du Vivier AW, CreamerD. Spectrum of clinical presentation, treatment and prognosisin a series of eight patients with leukaemia cutis.Clin Exp Dermatol 2006; 31: 218-221. doi: 10.1111/j.1365-2230.2005.02022.x.

  25. Grunwald MR, McDonnell MH, Induru R, Gerber JM.Cutaneous manifestations in leukemia patients. SeminOncol 2016; 43: 359-365. https://doi.org/10.1053/j.seminoncol.2016.02.020.




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