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Colegio de Medicina Interna de México.

2024, Number 4

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Med Int Mex 2024; 40 (4)

Eosinophilic fasciitis

Pimentel LRR, García CM, Chávez SIN

Language: Spanish
References: 17
Page: 276-282
PDF size: 398.88 Kb.


ABSTRACT

Background: Eosinophilic fasciitis is a rare sclerodermiform syndrome of unknown etiology, characterized by thickening of the muscle fascia and subcutaneous tissue and clinically presents with arthralgia, functional limitation, and thickening of deep tissues that conditions flexion contractures, with variable infiltration by eosinophils and peripheral eosinophilia; the diagnosis requires an adequate approach and, if possible, a skin, muscle and fascia block biopsy. Treatment is discussed and steroids and immunosuppressants are prescribed. Rituximab has currently shown good results in some cases and series.
Clinical case: A 19-year-old female patient who began acutely with skin hardening that lead to functional limitation associated with peripheral eosinophilia; eosinophilic fasciitis was concluded and she had a lack of response to usual treatment, which is why management with rituximab was started, with a good response.
Conclusions: The diagnosis of eosinophilic fasciitis is complex, it requires a high index of suspicion and extensive studies such as magnetic resonance imaging or biopsy; the latter is important but should not delay treatment, which is currently based on steroids and immunosuppressants, with good response; Rituximab may be a therapeutic option in refractory cases.


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