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2024, Number 2

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Sal Jal 2024; 11 (2)

Cytoprotective (anti-inflammatory and anticarcinogenic) effects of Persea americana: a panoramic review

Aguirre-Tello M, Wade-González ÓE, Vargas-López SE, Martínez-Amador V, Ley-Bernal F, Flores-Romo AA, Torres-Bugarín O

Language: Spanish
References: 28
Page: 69-77
PDF size: 330.75 Kb.


ABSTRACT

Introduction: avocado (Persea americana) is classified as a superfood that contains many beneficial compounds for health. These could be used as therapeutic adjuvants in pathologies such as cancer, inflammatory and metabolic diseases due to their antioxidant properties. Objective: to show the cytoprotective properties of Persea americana, its anticancer and anti-inflammatory activity through a bibliographic and panoramic search to make the reader aware of its benefits as a complementary treatment and daily consumption. Material and methods: panoramic review where the effects and cytoprotective compounds of Persea americana were evaluated in three scientific databases with a total of 37 experimental articles and bibliographic reviews. Results: Persea americana was found to be rich in antioxidant compounds such as polyphenols, carotenoids, vitamins, and glutathione, which was shown to have a cytoprotective effect on cancer, specifically breast, colon, gastrointestinal, and liver cancer. Conclusion: Persea americana is an easily accessible food for the Mexican population, which has proven to be effective as an adjuvant therapy in pathologies related to oxidative stress such as chronic inflammation and cancer due to its cytoprotective and antioxidant effects.


REFERENCES

  1. Padilla-Camberos E, Martínez-Velázquez M, Flores-Fernández JM, Villanueva-Rodríguez S. Acute toxicity and genotoxic activity of avocado seed extract (Persea americana Mill., c.v. Hass). ScientificWorldJournal. 2013;2013:245828. doi: 10.1155/2013/245828.

  2. Rodríguez-Martínez B, Ferreira-Santos P, Gullón B, Teixeira JA, Botelho CM, Yáñez R. Exploiting the potential of bioactive molecules extracted by ultrasounds from avocado peels-food and nutraceutical applications. Antioxidants (Basel). 2021;10(9):1475. doi: 10.3390/antiox10091475.

  3. Dabas D, Elias RJ, Ziegler GR, Lambert JD. In vitro antioxidant and cancer inhibitory activity of a colored avocado seed extract. Int J Food Sci. 2019;2019:6509421.

  4. Ochoa-Zarzosa A, Báez-Magaña M, Guzmán-Rodríguez JJ, Flores-Alvarez LJ, Lara-Márquez M, Zavala-Guerrero B, et al. Bioactive molecules from native Mexican avocado fruit (Persea americana var. drymifolia): A review. Plant Foods Hum Nutr. 2021;76(2):133-142. doi: 10.1007/s11130-021-00887-7.

  5. Ding H, Chin YW, Kinghorn AD, D'Ambrosio SM. Chemopreventive characteristics of avocado fruit. Semin Cancer Biol. 2007;17(5):386-394. doi: 10.1016/j.semcancer.2007.04.003.

  6. Roidaki A, Kollia E, Panagopoulou E, Chiou A, Varzakas T, Markaki P, et al. Super foods and Super herbs: Antioxidant and antifungal activity. Curr Res Nutr Food Sci J. 2016;4:138-145. doi: 10.12944/crnfsj.4.special-issue-october.

  7. Guzmán-Rodríguez JJ, López-Gómez R, Salgado-Garciglia R, Ochoa-Zarzosa A, López-Meza JE. The defensin from avocado (Persea americana var. drymifolia) PaDef induces apoptosis in the human breast cancer cell line MCF-7. Biomed Pharmacother. 2016;82:620-627. doi: 10.1016/j.biopha.2016.05.048.

  8. Bonilla-Porras AR, Salazar-Ospina A, Jimenez-Del-Rio M, Pereañez-Jimenez A, Velez-Pardo C. Pro-apoptotic effect of Persea americana var. Hass (avocado) on Jurkat lymphoblastic leukemia cells. Pharm Biol. 2014;52(4):458-465.

  9. Organización Mundial de la Salud. Cáncer. WHO; 2023. Disponible en: https://www.who.int/es/health-topics/cancer

  10. OPS. Día Mundial contra el Cáncer 2023: Por unos cuidados más justos. Paho.org. 2023. Disponible en: de https://www.paho.org/es/campanas/dia-mundial-contra-cancer-2023-por-unos-cuidados-mas-justos

  11. Gaviria Calle MM, Posada Arias S, Mira Hernández J. Acetogeninas, alternativa en el tratamiento de cáncer en caninos. CES Medicina Veterinaria Y Zootecnia. 2018;13(2):157-172.

  12. Alkhalaf MI, Alansari WS, Ibrahim EA, Elhalwagy MEA. Anti-oxidant, anti-inflammatory and anti-cancer activities of avocado (Persea americana) fruit and seed extract. J King Saud Univ Sci. 2019;31:1358-1362.

  13. Velderrain-Rodríguez GR, Quero J, Osada J, Martín-Belloso O, Rodríguez-Yoldi MJ. Phenolic-rich extracts from avocado fruit residues as functional food ingredients with antioxidant and antiproliferative properties. Biomolecules. 2021. 2;11(7):977. doi: 10.3390/biom11070977.

  14. National Library of Medicine. 2023. Available in: https://meshb.nlm.nih.gov/record/ui?ui=D019610

  15. Alonso Diaz T, Reyes Reyes E, Cueto González J, Martínez Carrasco J. Estrés oxidativo, terapia antioxidante y cáncer. Rev Cub Oncol. 2021;19(2):e117.

  16. Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative stress in cancer. Cancer Cell. 2020;38(2):167-197. doi: 10.1016/j.ccell.2020.06.001.

  17. Schroter D, Hohn A. Role of advanced glycation end products in carcinogenesis and their therapeutic implications. Curr Pharm Des. 2019;24(44):5245-5251. doi: 10.2174/1381612825666190130145549.

  18. Acosta Altamirano G, Frías de León MG, Reyes-Montes MR, Vargas Hernández V, Suárez Cuenca JA. Radicales libres y mecanismos de daño tisular en la diabetes mellitus. Rev Fac Med UNAM. 2011;54(3):46-53.

  19. Krause N, Wegner, A. Fructose metabolism in cancer. Cells. 2020;9(12):2635. doi: 10.3390/cells9122635.

  20. Torres-Bugarín O, Ramos-Ibarra, ML. Utilidad de la prueba de micronúcleos y anormalidades nucleares en células exfoliadas de mucosa oral en la evaluación de daño genotóxico y citotóxico. Int J Morphol. 2013;31(2):650-657. doi: 10.4067/S0717-95022013000200050.

  21. Iglesias Guevara D, Abreu Payrol J, Pérez Santana D, Cartaya Quintero R. Estudio fitoquímico preliminar y actividad antioxidante de un extracto acuoso de hoja de aguacate (Persea americana Mill.). QhaliKay. Revista de Ciencias de la Salud. 2021;5(3):56-65.

  22. Lee EA, Angka L, Rota SG, Hanlon T, Mitchell A, Hurren R, et al. Targeting mitochondria with avocatin B induces selective leukemia cell death. Cancer Res. 2015;75(12):2478-2488. doi: 10.1158/0008-5472.can-14-2676.

  23. Ramos-Aguilar AL, Ornelas-Paz J, Tapia-Vargas LM, Ruiz-Cruz S, Gardea-Béjar AA, Yahia EM, et al. The importance of the bioactive compounds of avocado fruit (Persea americana Mill) on human health. Biotecnia [en linea]. 2019;21(3):154-162[fecha de Consulta 30 de Abril de 2024]. Disponible en: https://www.redalyc.org/articulo.oa?id=672971084019

  24. Tremocoldi MA, Rosalen PL, Franchin M, Massarioli AP, Denny C, Daiuto ÉR, et al. Exploration of avocado by-products as natural sources of bioactive compounds. PLoS One. 2018;13(2):e0192577. doi: 10.1371/journal.pone.0192577.

  25. Márquez M, Zavala-Guerrero B, Salgado-Garciglia R, López-Gómez R, López-Meza JE. Bioactive molecules from native Mexican avocado fruit (Persea americana var. drymifolia): A review. Plant Foods Hum Nutr. 2021;76(2):133-142. doi: 10.1007/s11130-021-00887-7.

  26. Bhuyan DJ, Alsherbiny MA, Perera S, Low M, Basu A, Devi OA, et al. The odyssey of bioactive compounds in avocado (Persea americana) and their health benefits. Antioxidants (Basel). 2019;8(10):426. doi: 10.3390/antiox8100426.

  27. Ezzeddine K. Antioxidantes en el aguacate. Int J Mol Sci. 2018;26(4):189.

  28. D'Ambrosio SM, Han C, Pan L, Kinghorn AD, Ding H. Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway. Biochem Biophys Res Commun. 2011;409(3):465-469.




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