Olivares-Corichi IM, Medina-Navarro R, Torres-Ramos YD, Montes-Cortés DH

Language: Spanish
References: 14
Page: 237-240
PDF size: 128.90 Kb.

ABSTRACT

Free radicals are considered to be great importance as the causes of many disorders in general. In recent years, the metabolic syndrome has been associated with the presence protein oxidation, which can contribute to explain the lost of metabolic function and tissue damage under chronic conditions of oxidative stress. The free radicals produce alterations on low density lipoprotein by oxidation, provoking cytotoxic reactions in the endothelial cell, lost of receptor recognition concomitant with the consequently fagocytosis and accumulation of modified low density lipoprotein in the macrophages. The oxidative modification plays an important role in the early events of atherogenesis. In the other hands, the insulin can be oxidated by free radicals, producing chemical alterations and changes on their structure and function. Such changes might contribute to degenerative diseases like metabolic syndrome.

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