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Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2023, Number 1-3

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Alerg Asma Inmunol Pediatr 2023; 32 (1-3)

Proven invasive fungal infection by Stephanoascus ciferrii in the central nervous system in a patient with high-risk acute biphenotypic B-myeloid/myeloid B- cell leukemia

Murguía-Pérez JG, Arce-Cabrera D

Language: Spanish
References: 21
Page: 27-33
PDF size: 214.21 Kb.


ABSTRACT

Introduction: invasive fungal infections (IFI) caused by filamentous fungi continue to cause high morbimortality in patients with hematologic diseases and hematopoietic transplant recipients. This disease is classified as possible, probable, and proven according to the criteria of the European Organization for Research and treatment of cancer (EORTC). Stephanoascus ciferrii is a heterothallic, ascomycetous, yeast-like fungus that is a teleomorph of Candida ciferrii, whose isolation in humans is rare, especially in locations other than skin tissue and the peculiarity of this species to be resistant to fluconazole. Acute biphenotypic leukemia (ABL) is rare; it accounts for only 5% of all cases of acute leukemia. Case report: we present the case of a minor child diagnosed with high-risk biphenotypic B-cell/myeloid leukemia who presented with intermittent fever, irritability, developmental delay, skin nodules on the arm, profound and prolonged neutropenia; As part of the infectious diagnostic approach and in view of the developmental abnormalities, a lumbar puncture was performed, isolating Stephanoascus ciferrii, which confirmed the diagnosis of IFI, and treatment was initiated according to the Infectious Diseases Society of America (IDSA) guidelines for the treatment of candidiasis, which responded well. Conclusion: proper assessment of individual IFD risk is critical for choosing the best prophylactic and therapeutic approach and increasing patient survival.


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