2024, Number 1
<< Back Next >>
Med Int Mex 2024; 40 (1)
Mechanical power as a predictor of mortality in respiratory distress syndrome
Chirinos MS, Ibañez VBR, Ortega MRA
Language: Spanish
References: 21
Page: 3-11
PDF size: 218.01 Kb.
ABSTRACT
Objective: To determine the relationship among days on mechanical ventilation, days
in the intensive care unit, and mortality beyond 24 hours on outcome.
Materials and Methods: Observational, analytical and prospective cohort study
of two groups, living and deceased, performed in patients admitted to the Intensive
Care Unit of the Central Military Hospital of La Paz, Bolivia, in the years 2021 to 2022.
Results: One hundred twenty-two patients were included with a mean age of 63.7 ±
14.7 years; majority male 59.8% (n = 73). The mean APACHE II score was 16.11 ± 5.8
and SOFA 7.19 ± 1.59; 79.5% (n = 97) of patients were diagnosed with SARS-CoV-2
infection and 74.2% (n = 72) died. These data were significantly correlated between
ICU days and mechanical power equation values (p ≤ 0.000) and between ICU days
and invasive mechanical ventilation days (p ≤ 0.000).
Conclusions: Mechanical performance equation was the best predictor of poor
outcome. Continuous monitoring of mechanical ventilation favors safe management
in the intensive care unit, where it is a fundamental part of prognosis and prevention
of ventilator-induced lung injury.
REFERENCES
Rhodes A, Evans LE, Alhazzani P, Levy M, et al. Survivingsepsis campaign: International Guidelines for Managementof Sepsis and Septic Shock. Crit Care Med 2017; 45 (3). doi:10.1097/CCM.0000000000002255.
Aykac K, Ozsurekci Y, Tanir Basaranoglu S. Future directionsand molecular basis of ventilator associated pneumonia.Can Respir J 2017; 1 (2). doi: 10.1155/2017/2614602.
Ashbaugh D, Boyd Bigelow D, Petty T. Acute respiratorydistress in adults. Lancet 1967; 2. doi: 10.1016/s0140-6736(67)90168-7.
Azevedo LCP, Park M, Salluh JIF, Rea-Neto A, et al. Clinicaloutcomes of patients requiring ventilatory support in Brazilianintensive care units: a multicenter, prospective, cohortstudy. Crit Care 2013; 17 (2). https://doi.org/10.1186/cc12594.
Gattinoni L, Pesenti A, Avalli L, Rossi F. Pressure-volumecurve of total respiratory system in acute respiratory failure:Computed tomographic scan study. Am Rev Respir Dis1987; 136 (3). doi: 10.1164/ajrccm/136.3.730.
Gattinoni L, Tonetti T, Cressoni M. Ventilator-related causesof lung injury: the mechanical power. Intensive CareMedicine 2016; 42 (10). doi: 10.1007/s00134-016-4505-2.
Bachofen H. Lung tissue resistance and pulmonary hysteresis.J Appl Physiol 1968; 24 (3). https://doi.org/10.1152/jappl.1968.24.3.296.
Bellani G, Grassi A, Sosio S, Foti G. Plateau and driving pressurein the presence of spontaneous breathing. IntensiveCare Med 2019; 45 (1). doi: 10.1007/s00134-018-5311-9.
Amato MBP, Barbas CS, Medeiros DM, Magaldi RB, et al.Effect of a protective-ventilation strategy on mortality inthe acute respiratory distress syndrome. N Engl J Med 1998;338 (6). doi: 10.1056/NEJM199802053380602.
Drinker P, Shaw LA. An apparatus for the prolongedadministration of artificial respiration: I. A A Design forAdults and. J Clin Invest 1929; 7 (2): 229-47. doi: 10.1172/JCI100226.
Hutchinson J. On the capacity of the lungs, and onthe respiratory functions, with a view of establishinga precise and easy method of detecting disease bythe spirometer. Med Chir Trans 1846; 29: 137-252.doi:10.1177/095952874602900113.
Needham CD, Rogan MC, McDonald I. Normal standardsfor lung volumes, intrapulmonary gas-mixing, and maximumbreathing capacity. Thorax 1954; 9 (4): 313-25. doi:10.1136/thx.9.4.313.
Radford EP. Ventilation standards for use in artificialrespiration. J Appl Physiol 1955; 7 (4). doi: 10.1152/jappl.1955.7.4.451.
Bendixen HH, Whyte H, Laver MB. Impaired oxygenation insurgical patients during general anesthesia with controlledventilation. N Engl J Med 1963; 269 (19). DOI: 10.1056/NEJM196311072691901.
Pontoppidan H, Geffin B, Lowenstein E. Acute respiratoryfailure in the adult. N Engl J Med 1972; 16 (287). doi:10.1056/NEJM197210052871404.
Brochard L, Roudot-Thoraval F, Roupie E, Delclaux C, et al.Tidal volume reduction for prevention of ventilator-inducedlung injury in acute respiratory distress syndrome. Am JRespir Crit Care Med 1998; 6: 158.
Brower RG, Shanholtz CB, Fessler HE, Shade DM, White P,et al. Prospective, randomized, controlled clinical trial comparingtraditional versus reduced tidal volume ventilationin acute respiratory distress syndrome patients. Crit Care1999; 27 (8). doi: 10.1097/00003246-199908000-00015.
Stewart TE, Meade MO, Cook DJ, Granton JT, Hodder RV,et al. Evaluation of a ventilation strategy to prevent barotraumain patients at high risk for acute respiratory distresssyndrome. N Engl J Med 1998; 338 (6). doi: 10.1056/NEJM199802053380603.
Acute Respiratory Distress Syndrome Network; BrowerR, Matthay MA, Morris A, Schoenfeld D, et al. Ventilationwith lower tidal volumes as compared with traditionaltidal volumes for acute lung injury and the acute respiratorydistress syndrome. N Engl J Med 2000; 342 (18). doi:10.1056/NEJM200005043421801.
Curley GF, Laffey JG, Zhang H, Slutsky AS. Biotrauma andventilator- induced lung injury: Clinical implications. Chest2016; 150 (5). doi: 10.1016/j.chest.2016.07.019.
Rosas Sánchez K, Gutiérrez ZD, Cerón Díaz UW. Asociacióny valor predictivo del poder mecánico con los días. MedCrit 2017; 2017; 31.