2003, Number 3
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Gac Med Mex 2003; 139 (3)
Cutaneous Histoplasmosis and AIDS.
Reyes M, Arenas LR, Pichardo P, Vick R, Torres A, Zacarías R
Language: Spanish
References: 23
Page: 270-275
PDF size: 99.01 Kb.
ABSTRACT
Histoplasmosis is usually a lung infection due to Histoplasma capsulatum var Capsulatum. Skin lesions are present in 10 to 17% of cases and it appears to have higher prevalence in Mexico.
We report on three cases, all males with AIDS, of 26, 33 and 44 years of age. They presented fever, lymphadenopathy and weight loss. One had lingual ulcer and the other two, disseminated erythemato-violaceus plaques, papular and fistular lesions. The histopathologic study showed granulomatous lesions and Histoplasma capsulatum was isolated in cultures. All patients were treated successfully with amphotericin B with a total of 1.5 gm accumulative dose.
Clinical skin lesions of histoplasmosis and good response to treatment are discussed.
REFERENCES
Vick R, Arenas R, López JJ, Parraguirre S, Castro G, Fabian G. Histoplasma capsulatum: un agente causal frecuente de micosis en SIDA en México. Dermatol Rev Mex 1996;40(6):417-419.
Bellman B, Berman B, Sasken H, Kirsner RS. Cutaneous disseminated histoplasmosis in AIDS patients in South Florida. lnt J Dermatol 1997;36:599-603.
Taylor ML, Pedroza-Seres M, Gamez-Aranda A, Toriello C. Retrospective serological study of histoplasmosis in Mexico. Mycoses 1993;36:25-30.
Bonifaz A, Cancela R, Novales J, Montes de Oca G, Navarrete G, Romo J. Cutaneous histoplasmosis associated with acquired immunodeficiency syndrome (AIDS). lnt J Dermatol 2000;39:30-0.
Conant MA. Fungal infections in AIDS and other immunocompromised patients. J Am Acad Dermatol 1994;31:547-550.
Cahn P, Belloso WH, Murillo J, Prada-Trujillo G. AIDS in Latin America. lnfecti Dis Clin North America 2000;14 (1):185-209.
Cole MC, Cohen PR, Satra KH, et al. The concurrent presence of systemic disease pathogen and cutaneous Kaposi’s sarcoma in the same lesion: Histoplasma capsulatum and Kaposi’s sarcoma coexisting in a single skin lesion in a patient with AIDS. J Am Acad Dermatol 1992;26:285-287.
Wheat U, Síama TG, Zeckel Ml. Histoplasmosis in the acquired immunodeficiency syndrome. Am J Med 1985;78:203-210.
Cohen PR, Grossman ME, Silvers DN. Disseminated histoplasmosis and human immunodeficiency virus infection. lnt J Dermatol 1991;130:614-622.
Orozco-Topete ML, Reyes E. Histoplasmosis cutánea en nueve pacientes con SIDA. Rev lnvest Clin 1998;50(6):52-58.
Rodríguez G, Ordoñez N, Motta A. Histoplasma capsulatum var. capsulatum within cutaneous nerves in patients with disseminated histoplasmosis and AIDS (letter). Br J Dermatol 2001;144:205-207.
Wheat U, Connolly PA, Baker RL, Curfman MF, Eads ME, Israel KS, et al. Disseminated histoplasmosis in the acquired immune deficiency syndrome: clinical findings, diagnosis and treatment, and review of the literature. Medicine 1990; 69(6):361-374.
Edelman M, Mckitrick J. Histoplasma capsulatum, in peripheral blood smear. N Engl J Med. 2000;342(1):28.
Morbidity and Mortality Weekly Report from the CDC: 2001;50:261-262
Wheat U, Chetchotisakd P, Williams B, Connolly P, Shutt K, Hajjeh R. Factors associated with severe manifestations of histoplasmosis in AlDS. Clin lnfect Dis 2000; 30:877-1.
Porras B, Costner M, Friedman-Kien AE, Cockerell CJ. Update on cutaneous manifestations of HIV infection. Med Clini North Am 1998;82(5):1033-1077.
Akpek G, Lee SM, Gagnon DR, Cooley TP, Wright DG. Bone marrow aspiration, biopsy and culture in the evaluation of HIV- infected patients for invasive Mycobacteria and Histoplasma infections. Am J Hematol 2001; 67:100-106.
Eidbo J, Sánchez RL, Tschen JA, et al. Cutaneous manifestation of histoplasmosis in the acquired immunodeficiency syndrome. Am J Surg Pathol 1993;17:110-116.
Welykyk S, Von Heimburg A, Massa MC, et al. Cutaneous lesions of histoplasmosis with transepidermal elimination in a patient with acquired immunodeficiency syndrome. Cutis 1991;47: 397-400.
Lindgren AM, Fallon JD, Horan RF. Psoriasiform papules in the acquired immunodeficiency syndrome: disseminated histoplasmosis in AIDS. Arch Dermatol 1991;127:722-.
Cohen PR, HeId JL, Grossman ME. Disseminated histoplasmosis presenting as an ulcerated verrucous plaque in a human immunodeficiency virus-infected man. Int J Dermatol 1991;130:104-108.
Gumbo T, Just-Nubling G, Robertson V, et al. Clinicopathological features of cutaneous histoplasmosis in human immunodeficiency virus-infected patients in Zimbabwe. Trans R Soc Trop Med Hyg 2001;95:635-636.
Wheat U, Sarosi G, McKinsey D, Hamill R, Bradsher R, Johnson P, Loyd R, Kauffman C. Practice guidelines for the management of patients with histoplasmosis. Clin lnfect Dis 2000;30:688-695.