2021, Number 4
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Rev Cubana Farm 2021; 54 (4)
Pharmacological activity and phytochemical composition of Bidens pilosa L.
Calderín-Miranda JM, Aguiar MB, Díaz-Soto MT
Language: Spanish
References: 50
Page: 1-23
PDF size: 1024.86 Kb.
ABSTRACT
Introduction: Bidens pilosa L. is an annual herb from South America that
is widely spread throughout the world, especially in tropical and
subtropical regions. The rich phytochemical composition of Bidens pilosa allows
it to be used for the treatment of more than 41 types of diseases in humans and
animals.
Objective: Show through scientific evidence published in recent years, the broad
therapeutic spectrum of Bidens pilosa L.
Methods: A review of the literature published in the period 2011-2021, in English
and Spanish, available in Scielo, Scopus, Pubmed/Medline and Mediagraphic
repositories was carried out. Google Scholar search engine was used. A total of
142 documents were obtained in abstracts and full texts, of which 50 were
selected for the study, of which 82% were published in the last 5 years.
Conclusions: The knowledge generated in recent years about the
pharmacological properties of Bidens pilosa L. supports its wide traditional use
and opens paths to obtain products with marked therapeutic potential. The wide
spectrum of medicinal properties that it possesses places this plant as a source
of active metabolites that can be used, not only to treat a pathological
state, but to prevent its development.
REFERENCES
Angelini P, Matei F, Flores GA, Pellegrino RM, Vuguziga L, Venanzoni R, et al.Metabolomic Profiling, Antioxidant and Antimicrobial Activity of Bidens pilosa.Processes. 2021;9:903. DOI: 10.3390/pr9060903
Tello-Ceron G, Flores Pimentel M, Gómez Galarza V. Uso de las plantasmedicinales del Distrito de Quero, Jauja, Región Junín, Perú. Ecol Apl.2019;18(1). DOI: 10.21704/rea.v18i1.1301
Mtopi Bopda OS, Longo F, Boade F, Djomeni Dzeufiet PD, Dimo T. Subchronictoxicity of the leaf aqueous extract of Bidenspilosa Linn (Asteraceae) inmale and female rats. J Med Plant Res. 2016;10(38):676-85. DOI:10.5897/JMPR2016.6242
Dos Santos Filho EX, Costa Arantes DA, Oton Leite AF, Batista AC, MendonçaEF, Marreto RN, et al. Randomized clinical trial of a mucoadhesive formulationcontaining curcuminoids (Zingiberaceae) and Bidens pilosa Linn (Asteraceae)extract (FITOPROT) for prevention and treatment of oral mucositis - phase Istudy. Chem Biol Interact. 2018;291:228-36. DOI: 10.1016/j.cbi.2018.06.010
Benard P, Barugahare B. Effect of the Leaf Extract of Bidens pilosa onHaemostasis. J adv biol biotechnol. 2020;23(5):18-22. DOI:10.9734/jabb/2020/v23i530155
Liang YC, Lin CJ, Yang CY, Chen YH, Yang MT, Chou FS, et al. Toxicity studyof Bidens pilosa in animals. J Tradit Complement Med. 2019;10(2):150-57. DOI:10.1016/j.jtcme.2019.04.002
Kayondo Nakibuule M, Ntulume I, Chans Mwandah D, Tibyangye J, Bashir A,Odoki M, et al. Anti-bacterial Activity of Crude Flavonoid Fraction from Bidenspilosa Leaves against Selected Chronic Wound Bacterial Pathogens. JOCAMR.2019 [acceso 21/03/2021];8(1):1-13. Disponible en:https://journaljocamr.com/index.php/JOCAMR/article/view/30115
Boffil Cárdenas M, Cardellá Rosales L. La Bidens pilosa: planta medicinal queposee una amplia potencialidad terapéutica. Medicentro Electrónica. 2011[acceso 10/03/2021]. Disponible en:http://www.medicentro.sld.cu/index.php/medicentro/article/view/2244/1769
Parveen G, Ali M. Extraction Isolation and Phytochemical Screening of Leavesand Stems Of Bidens Pilosa and Evaluation of Antifungal Potential of Extracts. JPharm Pharm Sci. 2019;14(4):73-85. DOI: 10.9790/3008-1404027385
Falowo DE, Oladunmoye MK. Antibacterial Activity of Bidens pilosa Extractson Escherichia coli O157: H7 Isolated from Apparently Healthy Individuals.Asian J Med Health. 2018;11(2):1-10. DOI:https://doi.org/10.9734/AJMAH/2018/34516
Dang Xuan T, Dang Khanh T. Chemistry and pharmacology of Bidens pilosa:an overview. J Pharm Investig. 2016;46:91-132. DOI: 10.1007/s40005-016-0231-6
Kuo TF, Yang G, Chen TY, Wu YC, Nguyen Minh HT, Chen LS, et al. Bidenspilosa: Nutritional value and benefits for metabolic syndrome. Food Front.2020. DOI: 10.1002/fft2.63
Ramabulana AT, Steenkamp P, Madala N, Dubery IA. Profiling ofChlorogenic Acids from Bidens pilosa and Differentiation of Closely RelatedPositional Isomers with the Aid of UHPLC-QTOF-MS/MS-Based In-SourceCollision-Induced Dissociation. Metabolites. 2020;10:178. DOI:10.3390/metabo10050178
Xin YJ, Choi S, Roh KB, Cho E, Ji H, Weon JB, et al. Anti-InflammatoryActivity and Mechanism of Isookanin, Isolated by Bioassay-Guided Fractionationfrom Bidens pilosa L. Molecules. 2021;26:255. DOI: 10.3390/molecules26020255
Abdel-Ghany RH, Mohammed Barakat W, Abdelaziz Shahat A, Abd-Allah WE,Atef Ali E. In vitro and in vivo hepatoprotective activity of extracts of aerialparts of Bidens pilosa L (Asteraceae). Trop J Pharm Res. 2016;15(11):2371. DOI:10.4314/tjpr.v15i11.11
Shen AZ, Li X, Hu W, Chen FH. Total flavonoids of Bidens bipinnata L.ameliorate experimental adjuvant-induced arthritis through induction ofsynovial apoptosis. BMC Complement Altern Med. 2015;15:437. DOI:10.1186/s12906-015-0962-3
El-Kabany H, Ibrahim SI. Effect of Bidens pilosa extract on renal functionsand some tumor markers of Ehrlich Ascites Carcinoma bearing mice exposed toγ-radiation. J Rad Res Appl Sci. 2013;6(1):155-74. Disponible en:https://inis.iaea.org/search/searchsinglerecord.aspx?recordsFor=SingleRecord&RN=44113172
Hong M, Fan X, Liang S, Xiang W, Chen L, Yang Y, et al. Total Flavonoids ofBidens pilosa Ameliorates Bone Destruction in Collagen-Induced Arthritis.Planta Med. 2021;87(7):550-9. DOI: 10.1055/a-1352-5124
Nthulane NP, Mosebi S, Tshikalange TE, Nyila MA, Mankga LT. Antimicrobialand anti-inflammatory activities of selected medicinal plants against pathogenscausing sexually transmitted infections. J Herbmed Pharmacol. 2020;9(2):130-137. DOI: 10.34172/jhp.2020.17
Wahyuddin M, Nurdaonah F. Activity of Bidens Pilosa Herb Infusion asAntiinflammatory. Ad-Dawaa’ J Pharm Sci. 2020;3(1):66-71. DOI:10.24252/djps.v3i1.13945
Dos Santos Filho EX, Garcia da Silva AC, de Ávila RI, Carvalho Batista A,Neves Marreto R, Martins Lima E, et al. Chemopreventive effects of FITOPROTagainst 5-fluorouracil-induced toxicity in HaCaT cells. Life Sci. 2017;193:300-8.DOI: 10.1016/ j.lfs.2017.09.035
Ezeonwumelu JOC, Ntale M, Ogbonnia SO, Agwu E, Tanayen JK, Adedeji AA,et al. Analgesic Appraisal of Bidens pilosa (Asteraceae) Leaf Extracts Used inManagement of Oral Lesion Pain in HIV/AIDS Patients in Rodents. Pharm Phar.2018;9:175-92. DOI: 10.4236/pp.2018.96014
Zhang C, Li K, Yang Z, Wang Y, Si H. The Effect of the Aqueous Extract ofBidens Pilosa L. on Androgen Deficiency Dry Eye in Rats. Cell Physiol Biochem.2016;39:266-77. DOI: 10.1159/000445622
Fotso Fotso A, Longo F, Dzeufiet Djomeni PD, Fogue Kouam S, Spiteller M,Bertrand Dongmo A, et al. Analgesic and antiinflammatory activities of theethyl acetate fraction of Bidens pilosa (Asteraceae). Inflammopharmacol.2014;22:105-114. DOI: 10.1007/s10787-013-0196-2
Yi J, Wu JG, Wu YB, Peng W. Antioxidant and Anti-proliferative Activities ofFlavonoids from Bidens pilosa L var radiata Sch Bip. Trop J Pharm Res.2016;15(2):341. 10.4314/tjpr.v15i2.17
Cortés-Rojas DF, Chagas-Paula DA, Da Costa FB, Souza C, Oliveira W.Bioactive compounds in Bidens pilosa L. populations: a key step in thestandardization of phytopharmaceutical preparations. Rev Bras Farmacogn.2013;23(1):28-35. DOI: 10.1590/S0102-695X2012005000100
Wu J, Wan Z, Yi J, Wu Y, Peng W, Wu J. Investigation of the extracts fromBidens pilosa Linn. var. radiata Sch. Bip. for antioxidant activities andcytotoxicity against human tumor cells. J Nat Med. 2013;67:17-26. DOI:10.1007/s11418-012-0639-x
Kabanda MM, Gbashi S, Madala NE. Proportional coexistence of okaninchalcone glycoside and okanin flavanone glycoside in Bidens pilosa leaves andtheoretical investigation on the antioxidant properties of their aglycones. FreeRadic Res. 2020;55(1):53-70. DOI: 10.1080/10715762.2020.1859107
Shandukani PD, Tshidino SC, Masoko P, Moganedi KM. Antibacterial activityand in situ efficacy of Bidens pilosa Linn and Dichrostachys cinerea Wight et Arnextracts against common diarrhoea-causing waterborne bacteria. BMCComplement Altern Med. 2018;18:171. DOI: 10.1186/s12906-018-2230-9
Fotio AL, Dongmo Nguepi MS, Guemmogne Temdie RJ, Dimo T, NguelefackTB. Bidens pilosa Extract Effectively Alleviates Acetaminophen-InducedHepatotoxicity in Mice. EC Pharmacol Toxicol. 2019;7(11):119-31. Disponibleen: https://www.ecronicon.com/ecpt/pdf/ECPT-07-00387.pdf
Singh G, Passsari AK, Singh P, Leo VV, Subbarayan S, Kumar B.Pharmacological potential of Bidens pilosa L. and determination of bioactivecompounds using UHPLC-QqQLIT-MS/MS and GC/M. BMC Complement AlternMed. 2017;17:492. DOI: 10.1186/s12906-017-2000-0
Quaglio AEV, Cruz VM, Almeida-Junior LD, Costa C, Di Stasi LC. Bidenspilosa (Black Jack) Standardized Extract Ameliorates Acute TNBS-inducedIntestinal Inflammation in Rats. Planta Med. 2020;86(5):319-30. DOI:10.1055/a-1089-8342
Bosibori OM. Antibacterial activity and toxicity of non-aqueous extract ofBidens pilosa against Escherichia coli in female balb/c mice [Tesis de Maestría].[Kenya]: Repositorio Dspace, Maseno University; 2019 [acceso 10/03/2021].Disponible en: https://repository.maseno.ac.ke/handle/123456789/1441
Reisancho Quimbiulco LE. Influencia del método de extracción del aceiteesencial de hojas de amor seco (Bidens pilosa L.) en la actividad antimicrobiana[Trabajo de titulación previo a la obtención del Título de Químico Farmacéutico]. [Quito]: UCE; 2019 [acceso 12/03/2021]. Disponible en:http://www.dspace.uce.edu.ec/handle/25000/18659
Ajanaku C, Echeme J, Mordi R, Bolade O, Okoye S, Jonathan H, et al. Invitroantibacterial, phytochemical, antimycobacterial activities and GC-MSanalyses of Bidens pilosa leaf extract. J Microbiol Biotech Food Sci.2018;8(1):721-5. DOI: 10.15414/jmbfs.2018.8.1.721-725
Owoyemi OO, Oladunmoye MK. Phytochemical Screening and AntibacterialActivities of Bidens pilosa L. and Tridax procumbens L. on Skin Pathogens. Int JModern Biol Med. 2017;8(1):24-46. Disponible en: https://n9.cl/mgiwm
Yang C, Wong J, Lin C, Chang C, Chang CL. Using of animal models ofangiogenesis to confirm a Bidens pilosa-sourced polyacetylenic glucosideinhibits angiogenesis targeting hypoxia through VEGF and PDIA4 suppression.Preprints 2020. DOI: 10.20944/preprints202011.0198.v1
Nakama S, Tamaki K, Ishikawa C, Tadano M, Mori N. Efficacy of Bidenspilosa Extract against Herpes Simplex Virus Infection In Vitro and In Vivo. EvidBased Compl Alt. 2012;2012:413453. DOI: 10.1155/2012/413453
Nakama S, Ishikawa C, Nakachi S, Mori N. Anti-adult T-cell leukemia effectsof Bidens pilosa. Inter J Oncol. 2011;38:1163-73. DOI: 10.3892/ijo.2011.939
Noumedem Anangmo CN, Wabo Pone J, Kumar Kaushi N, Mohana krishnanD, Mittal Garima, Nguemfo Tchakugni A. In vitro Antiplasmodial Activity andCytotoxicity of Extracts and Fractions of Bidens Pilosa. Asian J BiomedPharmaceut Sci. 2017 [acceso 10/03/2021];(7):61. Disponible en:https://www.alliedacademies.org/articles/in-vitro-antiplasmodial-activityand-cytotoxicity-of-extracts-and-fractions-of-bidens-pilosa.pdf
Shen Y, Sun Z, Shi P, Wang G, Wu Y, Li S, et al. Anticancer effect ofpetroleum ether extract from Bidens pilosa L and its constituent's analysis byGC-MS. J Ethnopharmacol. 2018;2017:126-33. DOI: 10.1016/j.jep.2018.02.019
Mota CM, Santiago FM, Cardoso M, Rostkowska C, de Oliveira TC, Silva D, etal. Acetonic Fraction of Bidens pilosa Enriched for Maturase K Is Able to ControlCerebral Parasite Burden in Mice Experimentally Infected With Toxoplasmagondii. Front Vet Sci. 2019;6:55. DOI: 10.3389/fvets.2019.00055
Ajanaku C, Echeme JO, Mordi R, Ajani O, Okere D, Kayode A. Antimicrobialand GC-MS Analyses of Stem and Root Extracts of Bidens pilosa Linn. Orient JChem. 2019;35(2):839-48. DOI: 10.13005/ojc/350247
Mwende Mwaniki L, Mokua Mose J, Mutwiri T, Mulinge Mbithi J. Evaluationof Trypanocidal Activity of Bidens pilosa and Physalis peruviana AgainstTrypanosoma brucei rhodesiense. Am J Lab Med. 2017;2(4):69-73. DOI:10.11648/j.ajlm.20170204.15
Cornejo Báez AA. Evaluación de la actividad antibacteriana de los extractosy fracciones de Bidens pilosa L. y Xylosma flexuosum (H. B. & K.) Hemsl yestudio quimiométrico de la actividad antituberculosa de los perfilescromatográficos de Bidens pilosa L [Tesis de Maestría]. [Mexico]: RepositorioInternacional, Universidad Veracruzana; 2016 [acceso 12/03/2021]. Disponibleen: http://cdigital.uv.mx/handle/123456789/1272
Brito Álvarez G, Frías Vázquez AI, Morón Rodríguez FJ, García Delgado N,Cabrera Suárez JR, Morejón Rodríguez Z, et al. Validación preclínica del efectoantiinflamatorio tópico de cinco plantas medicinales. Rev cub plant med. 2014[acceso 05/03/2021];19(1). Disponible en:http://www.revplantasmedicinales.sld.cu/index.php/pla/article/view/116
Carvajal Carvajal C. Especies reactivas del oxígeno: formación, función yestrés oxidativo. Med leg Costa Rica. 2019 [acceso 30/03/2021];36(1):91-100.Disponible en:http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-00152019000100091&Ing=en
Ruiz-Pegoraro CM, Alborghetti Nai G, Alves Garcia L, Serra F, Apolônio AlvesJ, Nahas Chagas PE, et al. Protective effects of Bidens pilosa on hepatoxicityand nephrotoxicity induced by carbon tetrachloride in rats. Drug Chem Toxicol.2018;44(1): 64-74. DOI: 10.1080/01480545.2018.1526182
Bastos C, Ávila P, Filho E, Ávila R, Batista A, Fonseca S, et al. Use of Bidenspilosa L. (Asteraceae) and Curcuma longa L. (Zingiberaceae) to treat intestinalmucositis in mice: Toxicopharmacological evaluations. Toxicol Rep. 2016;3:279-87. DOI: https://doi.org/10.1016/j.toxrep.2015.10.013
Dai H, Wei S, Pogrzeba M, Krzyżak J, Rusinowski S, Zhang Q. The cadmiumaccumulation differences of two Bidens pilosa L. ecotypes from clean farmlandsand the changes of some physiology and biochemistry indices. EcotoxicolEnviron Saf. 2021;209. DOI: 10.1016/j.ecoenv.2020.111847