2022, Number 01
Use of dexamethasone for the prevention of postoperative nausea and vomiting in patients treated with laparoscopic cholecystectomy
Language: Spanish
References: 20
Page: 83-97
PDF size: 1243.58 Kb.
ABSTRACT
Introduction: The postoperative nausea and vomiting show a high incidence with the laparoscopic procedures and, also, they have been positioned as a marker of quality in anesthesiology.Objective: To determine the effectiveness of dexamethasone in the prevention of postoperative nausea and vomiting in patients operated on for gall bladder.
Methods: A therapeutic intervention was carried out in patients operated on for gall bladder by means of laparoscopy with balanced general anesthesia, at Dr. Juan Bruno Zayas Alfonso Teachig General Hospital in Santiago de Cuba, from January to December, 2018. Two groups were conformed: a study group, treated with dexamethasone, and a control group that received a placebo; whose members were selected in same number (50 for each group) by the simple random method.
Results: In both groups a higher frequency of the 33 to 46 ages and the female sex was obtained. The postoperative nausea were identified in 24.0 % of the study group, while, in the control group, it was higher percentage (52.0). Also the number of patients vomiting diminished when applying dexamethasone, because 90.0 % of those that received it didn't present this adverse reaction in the postoperative period, in comparison with 72.0 % of controls.
Conclusions: Dexamethasone reduced the appearance of postoperative nausea and vomiting, so that can be effective in the prevention of these secondary effects in patients intervened by laparoscopic cholecystectomy.
REFERENCES
Weibel S, Schaefer MS, Raj D, Rücker G, Pace NL, Schlesinger T, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anesthesia: An abridged Cochrane network meta-analysis. Anaesthesia. 2021 [citado 10/11/2021];76(7):962-73. Disponible en: https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15295
Shiraishi-Zapata CJ, Arellano-Adrianzén SJ, Rodríguez-Velarde GJ. Incidencia acumulada y factores de riesgo para náuseas y vómitos posoperatorios en pacientes adultos sometidos a colecistectomía bajo anestesia general balanceada: estudio prospectivo de cohorte. Rev Col Anest. 2020 [citado 10/11/2021];48(1):3-11. Disponible en: http://dx.doi.org/10.1097/CJ9.0000000000000142
Flores Gómez AA. Eficacia de dexametasona más ondansetrón vs ondansetrón en la prevención de náuseas y vómito posoperatorio en pacientes sometidos a colecistectomía abierta [tesis de especialidad]. Xalapa-Enríquez: Universidad Veracruzana; 2014 [citado 10/11/2021]. Disponible en: https://cdigital.uv.mx/bitstream/handle/123456789/41649/FloresGomezAlma.pdf?sequence=2&isAllowed=y
Vanegas Cuarezma KG. Comparación de la eficiencia de la dexametasona en dosis de 4 mg frente a dosis de 8 mg, como coadyuvante en la prevención de náuseas, vómitos y dolor posoperatorio en pacientes sometidos a cirugía electiva en el Hospital Escuela Antonio Lenin Fonseca de octubre 2016-febrero 2017 [tesis de especialidad]. Managua: Universidad Nacional Autonóma de Nicaragua; 2017 [citado 10/11/2021]. Disponible en: https://repositorio.unan.edu.ni/3979/1/96567.pdf
Liu J, Li H, Zhang J, Dong X, Xue J, Shi X, et al. Dexamethasone or combined with others for postoperative nausea and vomiting in children: A systematic review. Asian J Surg. 2020 [citado 10/11/2021];43(9):873-79. Disponible en: https://www.sciencedirect.com/science/article/pii/S1015958419308577?via%3Dihub
deGraft-Johnson PKG, Djagbletey R, Baddoo HK, Aniteye E, Essuman R, Aryee G, et al. Safety and efficacy of single-dose preoperative intravenous dexamethasone on postoperative nausea and vomiting following breast surgery at Korle-Bu Teaching Hospital. Ghana Med J. 2020 [citado 10/11/2021];54(4):207-14. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8042812/
Sridharana K, Sivaramakrishnan G. Drugs for preventing post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: Network meta-analysis of randomized clinical trials and trial sequential analysis. International Journal of Surgery. 2019 [citado 10/11/2021];69:1-12. Disponible en: https://www.sciencedirect.com/science/article/pii/S1743919119301542/pdfft?md5=a667a4a7652a97f29919b9ccdfe2765a&pid=1-s2.0-S1743919119301542-main.pdf