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ISSN 2683-1678 (Print)
Órgano Oficial de la Sociedad
Latinoamericana de lnfectología Pediátrica.
Órgano de la Asociación Mexicana de
Infectología Pediátrica, A.C.
Órgano difusor de la Sociedad Española
de lnfectología

2023, Number 4

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Rev Latin Infect Pediatr 2023; 36 (4)

Clinical-epidemiological characterization of acute respiratory infections in children under 5 years of age attended in a Third Level Hospital

Monroy-Colín VA, Martínez-Medina L, Cajero-Avelar A, Tejada-Martins E, Pinzón-Obregón CE

Language: Spanish
References: 11
Page: 161-167
PDF size: 205.87 Kb.


ABSTRACT

Introduction: acute viral respiratory diseases (AVRD) represent the first cause of morbidity in Mexico and worldwide. In the city of Aguascalientes, AVRD in 2020 were the main cause of morbidity in patients under 5 years of age, reporting a total of 37,944 cases. Objective: to identify the etiology and clinical and epidemiological characteristics of AVRD in children under 5 years of age after the first year of the COVID19 pandemic treated at the Centenario Hospital Miguel Hidalgo in Aguascalientes. Material and methods: an observational, descriptive, cross-sectional, ambispective study was carried out. A total of 318 children under 5 years of age with a diagnosis of ARVD attended between February 2021 and July 2022 who had multiplex RT-PCR determination to identify respiratory pathogens (BioFire FilmArray® respiratory panel 2.1, Biomerieaux) were studied. Descriptive statistics were used for the analysis of the variables. Results: the causative agent was detected in 83.3% of the cases; rhinovirus-enterovirus was found in 17.9%, respiratory syncytial virus (RSV) in 15.1%, SARS-CoV-2 in 6.6%, influenza A in 2.8% and coinfection was documented in 27.3% of the cases, coinfection of which was more frequent. Rhinovirus/RSV in 21 of 318 patients studied (6.6%). Seven deaths were observed during the study (100% of these patients with some comorbidity). Conclusions: during the study, a different seasonality of respiratory viruses could be observed than usual in the pre-pandemic period, the presence of RSV being notable mainly during the months of August 2021 to January 2022. The use of multiplexed RT-PCR panels allows the timely identification of respiratory pathogens with which a specific management can be established and avoids the unnecessary consumption of antimicrobials.


REFERENCES

  1. Secretaría de Salud. Programa de Acción Específico: Prevención y Control de las Enfermedades Respiratorias e Influenza, Programa Sectorial de Salud 2013-2018; México, 2014, 90.

  2. Marcone DN, Carballal G, Ricarte C, Echavarria M. Diagnóstico de virus respiratorios utilizando un sistema automatizado de PCR múltiples (FilmArray) y su comparación con métodos convencionales. Rev Argent Microbiol. 2015; 47 (1): 29-35.

  3. Ojeda PS, Munive LR, Moreno LLC, Torres GA, Melgar MV. Infecciones respiratorias y PCR múltiple: epidemiología de las infecciones respiratorias en pacientes pediátricos empleando metodología de PCR múltiple. Rev Latinoam Patol Clin Med Lab 2016; 63 (4): 190-195.

  4. Sosa-Ceh GN, Moreno-Espinoza S, Jiménez-Juárez R. Evaluación del uso inapropiado de antimicrobianos en infecciones respiratorias bajas en el Hospital Infantil de México Federico Gómez. Medicine. 2021; 33 (135): 1820-1825.

  5. Cofré J, Pavez D, Pérez R, Rodríguez J. Recomendaciones para el diagnóstico y tratamiento antimicrobiano de la neumonía bacteriana adquirida en la comunidad en pediatría. Rev Chil Infectol. 2019; 36 (4): 505-512.

  6. Poritz MA, Blaschke AJ, Byington CL, Meyers L, Nilsson K, Jones DE et al. FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection. PLoS One. 2011; 6 (10): e26047.

  7. Secretaría de Salud. Anuario de Morbilidad 1984-2021. Dirección General de Epidemiología; Disponible en: https://epidemiologia.salud.gob.mx/anuario/html/index.html

  8. Secretaría de Salud; Lineamiento estandarizado para la vigilancia epidemiológica y por laboratorio de la enfermedad respiratoria viral. Subsecretaría de prevención y promoción de la Salud, Dirección General de Epidemiología; Comité Nacional para la Vigilancia Epidemiológica; 2021; 53 (9): 87.

  9. Wong-Chew RM, García-León ML, Noyola DE, Perez Gonzalez LF, Gaitan Meza J, Vilaseñor-Sierra A et al. Respiratory viruses detected in Mexican children younger than 5 years old with community-acquired pneumonia: a national multicenter study. Int J Infect Dis. 2017; 62: 32-38.

  10. Noyola DE, Zuviri-González A, Castro-García JA, Ochoa-Zavala JR. Impact of respiratory syncytial virus on hospital admissions in children younger than 3 years of age. J Infect. 2007; 54 (2): 180-184.

  11. Zhu G, Xu D, Zhang Y, Wang T, Zhang L, Gu W. Epidemiological characteristics of four common respiratory viral infections in children. Virol J. 2021; 1-5.




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