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2023, Number 3

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Rev Educ Bioquimica 2023; 42 (3)

La citocina TGF-β en la salud y la enfermedad

Síntesis, secreción y activación de la citocina TGF-β en la salud y la enfermedad

Toledo PD, Coquis BDA, Sosa GM, Macías SM

Language: Spanish
References: 38
Page: 141-151
PDF size: 679.23 Kb.


ABSTRACT

TGF-β is a cytokine synthesized and secreted in a latent form, forming a complex with a latency-associated peptide called LAP. TGF-β can be secreted in a soluble form or as a cargo of extracellular vesicles. There are different signals that induce its expression and distinct mechanisms that lead to its activation upon releasing it from the complex with LAP to initiate its signaling.


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