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2023, Number 2

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rev homeostasis 2023; 5 (2)

Factores cardiometabólicos y de composición corporal asociados a proteinuria en estudiantes universitarios

López ZPT, Torres MXM, Parra RE, García GOY, Pérez RFR

Language: Spanish
References: 25
Page:
PDF size: 462.68 Kb.


ABSTRACT

Background: Chronic kidney disease (CKD) affects one in 10 adults worldwide and its incidence is expected to increase. The identification of risk factors in asymptomatic adults has been proposed as a feasible alternative to reduce its incidence, with proteinuria being a predictor of renal function. Material and methods: Material and methods: This observational study of 20 apparently healthy university students in Guadalajara, Jalisco, aimed to investigate the association between cardiometabolic and body composition factors (CBCF) and the presence of proteinuria. The collected data was analyzed using Spearman correlation and logistic regression. Results: Spearman's correlation revealed an association between proteinuria and male sex, extracellular water/total body water ratio (ECW/TBW), skeletal muscle mass (SMM), total body fat percentage (BFP) and total body water (TBW), Logistic linear regression analysis showed that SMM, BFP, TBW, total protein, and urobilinogen were predictors of proteinuria. Discussion and conclusions: Contrary to current evidence, we found a positive association between SMM and proteinuria. We propose that physical activity might explain this phenomenon. Hence proteinuria might be influenced by level of physical activity and thus might not be an ideal biomarker of renal involvement in young adults.


REFERENCES

  1. Sundström J, Bodegard J, Bollmann A, Vervloet MG, Mark PB, Karasik A, et al. Prevalence, outcomes, and cost of chronic kidney disease in a contemporary population of 2·4 million patients from 11 countries: The CaReMe CKD study. Lancet Reg Health Eur. 2022 Sep;20:100438.

  2. Jadhakhan F, Marshall T, Ryan R, Gill P. Risk of chronic kidney disease in young adults with impaired glucose tolerance/impaired fasting glucose: a retrospective cohort study using electronic primary care records. BMC Nephrol. 2018 Feb 26;19(1):42.

  3. Gunawardena S, Dayaratne M, Wijesinghe H, Wijewickrama E. A Systematic Review of Renal Pathology in Chronic Kidney Disease of Uncertain Etiology. Kidney Int Rep. 2021 Jun;6(6):1711–28.

  4. Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V. Chronic kidney disease. Lancet Lond Engl. 2021 Aug 28;398(10302):786–802.

  5. Evans M, Lewis RD, Morgan AR, Whyte MB, Hanif W, Bain SC, et al. A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives. Adv Ther. 2022 Jan;39(1):33–43.

  6. Garcia Sanchez JJ, Thompson J, Scott DA, Evans R, Rao N, Sörstadius E, et al. Treatments for Chronic Kidney Disease: A Systematic Literature Review of Randomized Controlled Trials. Adv Ther. 2022 Jan;39(1):193–220.

  7. Pérez-Navarro LM, Valdez-Ortiz R, Alegría-Díaz A, Murguía-Romero M, Jiménez-Flores R, Villalobos-Molina R, et al. CARDIOMETABOLIC RISK FACTORS ASSOCIATED WITH RENAL FUNCTION IN APPARENTLY HEALTHY YOUNG STUDENTS: A CROSS-SECTIONAL STUDY. Rev Investig Clin Organo Hosp Enfermedades Nutr. 2020;72(2):95–102.

  8. Agudelo-Botero M, Valdez-Ortiz R, Giraldo-Rodríguez L, González-Robledo MC, Mino-León D, Rosales-Herrera MF, et al. Overview of the burden of chronic kidney disease in Mexico: secondary data analysis based on the Global Burden of Disease Study 2017. BMJ Open. 2020 Mar 25;10(3):e035285.

  9. Polanco-Flores NA. Chronic renal disease in Mexico: A preventive uncontrolled epidemic. Rev Médica Hosp Gen México. 2019 Dec;82(4):194–7.

  10. Esparza-Aguilar M, Ochoa-Esquivel R del C, Barajas-González A, Ávila-Rosas H, Esparza-Aguilar M, Ochoa-Esquivel R del C, et al. Mortalidad en México por enfermedad renal crónica en menores de 20 años de edad, 2000-2014. Rev Mex Pediatría. 2019 Apr;86(2):58–64.

  11. Duan JY, Duan GC, Wang CJ, Liu DW, Qiao YJ, Pan SK, et al. Prevalence and risk factors of chronic kidney disease and diabetic kidney disease in a central Chinese urban population: a cross-sectional survey. BMC Nephrol. 2020 Apr 3;21(1):115.

  12. Okwuonu CG, Chukwuonye II, Adejumo OA, Agaba EI, Ojogwu LI. Prevalence of chronic kidney disease and its risk factors among adults in a semi-urban community of South-East Nigeria. Niger Postgrad Med J. 2017;24(2):81–7.

  13. Bristol U of. Laboratory techniques [Internet]. University of Bristol; [cited 2023 Mar 4]. Available from: https://www.bristol.ac.uk/vet-school/research/comparative-clinical/veterinary-education/clinical-skills-booklets/laboratory-techniques/

  14. Tewari A, Tewari V, Tewari J. A Cross-Sectional Study for Prevalence and Association of Risk Factors of Chronic Kidney Disease Among People With Type 2 Diabetes in the Indian Setting. Cureus. 2021 Sep;13(9):e18371.

  15. Memarian E, Nilsson PM, Zia I, Christensson A, Engström G. The risk of chronic kidney disease in relation to anthropometric measures of obesity: A Swedish cohort study. BMC Nephrol. 2021 Oct 5;22(1):330.

  16. Wang F, He K, Wang J, Zhao MH, Li Y, Zhang L, et al. Prevalence and Risk Factors for CKD: A Comparison Between the Adult Populations in China and the United States. Kidney Int Rep. 2018 Sep;3(5):1135–43.

  17. Michishita R, Matsuda T, Kawakami S, Tanaka S, Kiyonaga A, Tanaka H, et al. Hypertension and hyperglycemia and the combination thereof enhances the incidence of chronic kidney disease (CKD) in middle-aged and older males. Clin Exp Hypertens N Y N 1993. 2017;39(7):645–54.

  18. Teo BW, Chan GC, Leo CCH, Tay JC, Chia YC, Siddique S, et al. Hypertension and chronic kidney disease in Asian populations. J Clin Hypertens Greenwich Conn. 2021 Mar;23(3):475–80.

  19. Cha’on U, Tippayawat P, Sae-Ung N, Pinlaor P, Sirithanaphol W, Theeranut A, et al. High prevalence of chronic kidney disease and its related risk factors in rural areas of Northeast Thailand. Sci Rep. 2022 Oct 28;12(1):18188.

  20. Low S, Pek S, Liu YL, Moh A, Ang K, Tang WE, et al. Higher extracellular water to total body water ratio was associated with chronic kidney disease progression in type 2 diabetes. J Diabetes Complications. 2021 Jul;35(7):107930.

  21. Zhou Y, Hellberg M, Svensson P, Höglund P, Clyne N. Sarcopenia and relationships between muscle mass, measured glomerular filtration rate and physical function in patients with chronic kidney disease stages 3-5. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc. 2018 Feb 1;33(2):342–8.

  22. Fan CH, Lin SC, Tsai KZ, Wu TJ, Lin YP, Lin YK, et al. Association of Single Measurement of dipstick proteinuria with physical performance of military males: the CHIEF study. BMC Nephrol. 2020 Jul 18;21(1):287.

  23. Chen YY, Fang WH, Wang CC, Kao TW, Chang YW, Yang HF, et al. Changes of PercentBody Fat as a Useful Surrogate for Risk of Declined Renal Function. Sci Rep. 2018 Nov 23;8(1):17289.

  24. Currin SD, Gondwe MS, Mayindi NB, Chipungu S, Khoza BL, Tollman S, et al. Diagnostic accuracy of semiquantitative point of care urine albumin to creatinine ratio and urine dipstick analysis in a primary care resource limited setting in South Africa. BMC Nephrol. 2021 Mar 20;22(1):103.

  25. Wang Q, Ishizawa K, Li J, Fujii W, Nemoto Y, Yamazaki O, et al. Urinary phosphate-containing nanoparticle contributes to inflammation and kidney injury in a salt-sensitive hypertension rat model. Commun Biol. 2020 Oct 15;3(1):1–12.




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