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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2023, Number 3

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Rev Biomed 2023; 34 (3)

Receptor for advanced glycation end products (RAGE) as a childhood obesity biomarker

Vega-Cárdenas M, Portales-Pérez DP, Vargas-Morales JM, Aradillas-García C

Language: Spanish
References: 63
Page: 296-305
PDF size: 228.01 Kb.


ABSTRACT

Introduction. Hyperglycemia and hyperlipidemia contribute to the endogenous formation of advanced glycation end products (AGEs), and diet constitutes one of the exogenous sources. The binding of AGEs to receptor for glycation end products (RAGE) induces signaling pathways that activate the transcription of inflammatory and oxidative stress markers. Soluble RAGE (sRAGE) levels have been proposed as a biomarker in inflammatory diseases. Several studies describe the role of RAGE in obesity, so it has been discussed whether there is a differential pattern between children with normal weight and obesity. Several studies describe the role of RAGE in obesity, so it has been discussed whether there is a differential pattern between children with normal weight and obesity.
Aim. Describe the relationship between RAGE, its isoforms, ligands, biological functions, and comorbidities related to childhood obesity. To determine if decreased sRAGE levels represent a biomarker of childhood obesity based on the results of clinical, observational, and cross-sectional studies.
Methodology. Descriptive review of studies published in the period from 2016 to 2022 in the PubMed and Google Scholar databases using the terms “AGEs”, “RAGE”, “sRAGE”, “childhood obesity”.
Results and conclusion. A total of 141 articles related to the keywords were consulted. The elimination criteria consisted of references published before 2015, except for classic references. 63 articles from 2016 to 2022 were reviewed, six represent cross-sectional studies on sRAGE levels in the pediatric population, finding differences in the expression of RAGE according to nutritional status.


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