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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2023, Number 2

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Rev Biomed 2023; 34 (2)

Role of Par-4 in late-stage and recurrent breast cancer tumors

Zapata-Benavides P, Arellano-Rodríguez NC, Rodríguez-Padilla MC

Language: Spanish
References: 73
Page: 224-234
PDF size: 383.43 Kb.


ABSTRACT

Deaths in patients with breast cancer occur mainly due to recurrence and metastasis and not by the primary tumor, the aggressiveness of the tumor is associated with hormonal status, and estrogen receptor negative or triple negative tumors are neoplasms of poor prognosis that can induce metastasis or recurrence the low expression of Par-4 is associated with a poor prognosis, for this reason, we analyzed the involvement of Par-4 in tumor recurrence. A search was carried out for articles related to breast cancer, recurrence, and Par-4 in PubMed and other databases, to understand the relationship of Par-4 as a tumor suppressor gene with the carcinogenic process and recurrence of breast cancer. Low Par-4 expression is associated with estrogen receptor negative tumors or with a high degree of transformation, the expression of Par-4 decreases or is blocked in the remaining cells after chemotherapy and during the process of epithelial mesenchymal transition (EMT) in tumor recurrence, noting that Par-4 is necessary and essential for the recurrence of breast cancer. The understanding of the biology of Par-4 in breast cancer opens the possibility of being used as a therapeutic strategy to contribute to the elimination of resistant or recurrent breast cancer tumors.


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