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2023, Number 3

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Acta Pediatr Mex 2023; 44 (3)

Epidemiology, Clinical Manifestations, and Pathophysiology of Multisystem Inflammatory Syndrome in Children

Rodríguez-Lozano AL, Toledo-Salinas CC, Bayardo-Gutiérrez B, Nájera-Velázquez RG

Language: Spanish
References: 95
Page: 221-241
PDF size: 397.50 Kb.


ABSTRACT

The pediatric multi-system inflammatory syndrome has been recognized as an emerging condition; a new spectrum of pediatric disease associated with SARS-CoV-2 infection. This syndrome was initially identified in Europe and was named PIMS-TS (Pediatric Inflammatory Multisystem Syndrome - Temporally associated with SAR-CoV-2) subsequent in the United States of America was designated MIS-C (Multisystem Inflammatory Syndrome in Children), when in May 2020, the WHO coined the term. The incidence of MIS-C in patients younger than 21 years infected with SARS-CoV-2 is 5.1 per 1,000,000 person-months [95% CI 4.5 to 5-8] and is higher in African American and Hispanic or Latinos versus Caucasians. In this article, we summarize the main findings of this syndrome in terms of epidemiology, clinical manifestations, and pathophysiology. Finally, we will present information about whether MIS-C belongs to the spectrum of Kawasaki disease.


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