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Revista Médica Sinergia

2023, Number 06

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Revista Médica Sinergia 2023; 8 (06)

Osteosarcoma: pathophysiology, diagnosis and treatment

Madrigal-Calderón JP, Amador-Méndez AL, Rivera-Sandoval N

Language: Spanish
References: 15
Page:
PDF size: 192.17 Kb.


ABSTRACT

Osteosarcoma is a rare malignant tumor that affects the bone. It has mesenchymal origin, and its incidence is higher during childhood and adolescence. In most cases, it develops in the metaphysis of long bones and clinically manifests with episodes of bone pain that may be accompanied by constitutional symptoms. It can be classified according to its grade, location and histological pattern; high-grade OS accounts for 90% of all cases and presents accelerated growth and grater aggressiveness. A bone biopsy is necessary to make a definitive diagnosis. Its definitive treatment includes surgery along with neoadjuvant and adjuvant chemotherapy, using the MAP regimen, which combines three chemotherapeutic agents and has proven to be the most effective, with an overall survival increase from 20% to 70%. Despite the efforts of the scientific community to develop new therapies that offer a better response, none of these has shown better results yet.


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