2023, Number 1
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Enf Infec Microbiol 2023; 43 (1)
Coronavirus, from the molecular to the clinical: a review
Roldán TMD, Cuartas AYS, Herrera AL, Castañeda PS, Coronado MG, Martínez SLM
Language: Spanish
References: 56
Page: 35-41
PDF size: 212.28 Kb.
ABSTRACT
Since the end of 2019, a significant increase infections due to SARS-COV-2 were detected around the world, and World
Health Organization (WHO) declaring a pandemic. SARS-COV-2 generates a severe acute respiratory syndrome and
affection to different organs due to the interaction between its four main proteins and the receptors of human cells
through the angiotensin-converting enzyme 2 receptor. Comorbidities and some clinical characteristics has been
described as risk factors to develop a severe infection. Although several diagnostic methods of this disease have
been proposed, reverse transcriptase polymerase chain reaction (PCR) is recommended. Vaccines production has
been difficult due to virus mutations, however, different vaccines has been approved and applied in many countries
of the world.
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