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ISSN 2078-7170 (Electronic)

2021, Number 4

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CorSalud 2021; 13 (4)

Carbamazepine and cardiac conduction disorders: A case series

Pérez RT, Martínez GG, García MAJ, Carrero VAM, Reinosa PN, González MY, Bonilla PD

Language: Spanish
References: 15
Page: 481-486
PDF size: 242.77 Kb.


ABSTRACT

Carbamazepine is an antiepileptic drug chemically related to tricyclic antidepres-sants. In therapeutic doses, it is not arrhythmogenic, but when toxic values are reached, it produces blockage of sodium channels, which favors the appearance of cardiac arrhythmias; sometimes it can lead to blockages of the cardiac conduction system. We present a series of four patients who were admitted with cardiac con-duction disorders and were taking carbamazepine at the time of admission. All were hypertensive, 75% were women, and three of them had used the drug for a period of more than one year. The most frequent reason for admission was decay, requiring permanent pacemaker implantation, and one patient died after using carbamazepine again (defined causality). The remaining three had a possible cau-sality with the consumption of this drug.


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