2023, Number 2
<< Back Next >>
Rev Fac Med UNAM 2023; 66 (2)
Mucinous Carcinoma of the Breast: A Rare Histological Type with a Favorable Prognosis
Santiago SL, Porras IGD, Malfavón FM, Méndez HG
Language: Spanish
References: 21
Page: 29-37
PDF size: 336.74 Kb.
ABSTRACT
Mucinous carcinoma is a rare type of breast cancer, which
represents less than 4% of all primary cancers. It usually occurs
in postmenopausal patients, around the seventh decade of
life. Clinically, it is characterized by the presence of a palpable
nodule, rarely accompanied by other symptoms.
Imaging tools, such as mammogram and ultrasound, are
essential for its diagnosis, however, in some situations the
diagnosis can be underestimated due to the similar characteristics
that it shares with other benign lesions. Definitive
diagnosis is made by histopathology.
Regarding treatment, there is no consensus on the most
appropriate, due to the low incidence of these tumors. Many
authors agree that surgical intervention continues to be the
best option, showing a positive impact on survival and low
recurrences. This can be accompanied later by adjuvant endocrine
therapies. Fortunately, the prognosis of this type
of tumor is usually favorable, even survival exceeds 90% at
5 years.
REFERENCES
Budzik MP, Fudalej MM, Badowska-Kozakiewicz AM.Histopathological analysis of mucinous breast cancersubtypes and comparison with invasive carcinoma of nospecial type. Sci Rep. 2021;11(1):1-9. doi:10.1038/s41598-021-85309-z
Jang Y, Jung H, Kim HN, et al. Clinicopathologic characteristicsof HER2-positive pure mucinous carcinomaof the breast. J Pathol Transl Med. 2020;54(1):95-102.doi:10.4132/jptm.2019.10.24
Achicanoy Puchana DM, Lasso Andrade FA, AchicanoyPuchana DF, et al. Mucinous carcinoma of the breast: Diagnosisand management of an unusually young patient.Radiol Case Reports. 2022;17(5):1445-1449. doi:10.1016/j.radcr.2022.02.011
Wang PL, Zheng FY, Lu Q, et al. Imaging features of puremucinous breast carcinoma: correlation with extracellularmucus content. Clin Radiol. 2019;74(7):569.e9-569.e17.doi:10.1016/j.crad.2019.01.031
Zhao X, Yang X, Gao R, Zhai L, Yang L, Yu K. HER2-positivepure mucinous breast carcinoma: A case report and literaturereview. Medicine (Baltimore). 2020;99(33):e20996.doi:10.1097/MD.0000000000020996
Marrazzo E, Frusone F, Milana F, et al. Mucinous breastcancer: A narrative review of the literature and a retrospectivetertiary single-centre analysis. Breast. 2020;49:87-92.doi:10.1016/j.breast.2019.11.002
Pareja F, Lee JY, Brown DN, et al. e Genomic Landscapeof Mucinous Breast Cancer. J Natl Cancer Inst.2019;111(7):737-741. doi:10.1093/jnci/djy216
Gok, Mustafa;Topal U, Oz, BahadirAkgun H, Akcan AC,Sozuer EM. Comparison of Clinical Features and TreatmentResults of Mix Mucinous Carcinomas and OtherAtypical Carcinomas of the Breast. Eur J Breast Heal.2019;15(4):222-228. doi:10.5152/ejbh.2019.5032
Hu T, Huang J, Fang K. Overall Survival in Patients withMucinous Carcinoma of Breast: A Population-Based Study.Int J Gen Med. 2021;Volume 14:9991-10001. doi:10.2147/ijgm.s343137
Ginter PS, Tang X, Shin SJ. A review of mucinous lesionsof the breast. Breast J. 2020;26(6):1168-1178. doi:10.1111/tbj.13878
Gwark S chan, Lee HS, Lee Y, et al. Clinical Implicationof HER2 Status in Hormone Receptor-Positive MucinousBreast Cancer. Ann Surg Oncol. 2019;26(7):2166-2174.doi:10.1245/s10434-019-07332-9
Isozaki H, Yamamoto Y, Sakai K, et al. Mucinous carcinomaof the breast: Clinicopathological features andlong-term prognosis in comparison with invasive ductalcancer; A single hospital’s 30+-year experience. Acta MedOkayama. 2020;74(2):137-143.
Nguyen B, Veys I, Leduc S, et al. Genomic, Transcriptomic,Epigenetic, and Immune Proling of Mucinous Breast Cancer.J Natl Cancer Inst. 2019;111(7):742-746. doi:10.1093/jnci/djz023
Lu K, Wang X, Zhang W, et al. Clinicopathological andgenomic features of breast mucinous carcinoma. Breast.2020;53:130-137. doi:10.1016/j.breast.2020.07.010
Risner V, Jordan S. Mucinous carcinoma in an octogenarian:Treatment and management of breast cancer inthe elderly. Radiol Case Reports. 2021;16(11):3201-3207.doi:10.1016/j.radcr.2021.07.077
Cserni G. Histological type and typing of breast carcinomasand the WHO classication changes over time. Pathologica.2020;112(1):25-41. doi:10.32074/1591-951X-1-20
Asano Y, Kashiwagi S, Nagamori M, et al. Pure MucinousBreast Carcinoma with Micropapillary Pattern (MUMPC):A Case Report. Case Rep Oncol. 2019;12(2):554-559.doi:10.1159/000501766
Du P, Hou C, Tang J, et al. A Case of Pure MucinousBreast Carcinoma in a 25-Year-Old Female Who ShowedComplete Pathological Response to Neoadjuvant Chemotherapydespite Poor Clinical Response. Breast Care.2020;15(5):538-542. doi:10.1159/000504125
Xiang F, Duan Y, Wang J, Xie M. Concurrent pure mucinousbreast carcinoma and osteogenesis imperfecta.Asian J Surg. 2022 Jun;45(6):1361-1362. doi:10.1016/j.asjsur.2022.02.020
Baig A, Omeroglu-Altinel G, Omeroglu A. Invasive Pleomorphic-Type Lobular Carcinoma of the Breast Presentingas a Mucinous Carcinoma. Case Rep Pathol. 2019;2019:1-5.doi:10.1155/2019/1839208
Sun M, Su S, Liu Q, Li Q, Wang K. Mammary synchronousmucinous cystadenocarcinoma and columnar cellmucinous carcinoma: a case report. Int J Clin Exp Pathol.2020;13(9):2381-2386.