Gallegos HJF, Minauro MG, Apresa T, Arias CH, Hernández SM, Flores DR, Reséndiz CJ, Hernández HDM

Language: Spanish
References: 21
Page: s36-40
PDF size: 156.52 Kb.

ABSTRACT

Introduction: head & Neck squamous cell carcinoma (HNSCC) is the world's 6th most common cancer. 400,000 HNSCC were diagnosed in 2005 throughout the world, the most frequently affected site is oral cavity. Alcohol-tobacco consumption is the most important risk factor of this neoplasia; nevertheless, since 1983 it was suggested that HPV have a role in HBNSCC mainly in oropharynx (level 1 evidence). Objective: to assess HPV prevalence and types in patients with HNSCC. Material and methods: presence of HPV was determined by polymerase chain reaction and staged by hybridization in situ. We analyzed stage, tumor site of origin, sex habits, alcohol-tobacco consumption. We performed T test and Fisher's exact test. We performed a multiple regression analysis for variables' adjustment. Results: 118 consecutive patients with squamous cell carcinoma of the head and neck were analyzed, in 68 (57%) the tumor was located in the oral cavity, in 24 patients (35%) HPV DNA was identified, in 19 (79%) high-risk (HPV-16). HPV was found more frequently in smokers and drinkers. Conclusion: HPV is associated with 35% of patients with oral cavity cancer, 70% of high risk and could be a cofactor as alcohol and tobacco in the oncogenesis of this neoplasm.

REFERENCES

1. Parkin DM, Bray FI, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001; 94: 153-156.

2. Warnakulasuriya S. Global trends in the epidemiology of oral cancer; the current position. Oral Oncol 2005; 1: 27. Abstract K-1.

3. Secretaría de Salud. Dirección General de Epidemiología. Registro Histopatológico de Cáncer. México 2002.

4. Schantz SP, Harrison LB, Hong WK. Tumors of the nasal cavity and paranasal sinuses, nasopharynx, oral cavity and oropharynx. In: Devita VT Jr, Helman S, Rosemberg SA, eds. Cancer: Principles and practice of oncology. Philadelphia: JB Lippincott, 1993: 574-630.

5. Gallegos HJF. Head and neck cancer. Prognostic factors and prevention. Cir Ciruj 2006; 74: 287-293.

6. Jarret WFH. Environmental carcinogens and papillomaviruses in the pathogenesis of cancer. Proc R Soc Lond B Biol Sci 1987; 231: 1-11.

7. Rosenquist K, Wennerberg J, Annertz K et al. Human papillomavirus contributes to oral and oropharyngeal squamous cell carcinoma and to recurrence after treatment. Abst S101. 2006 Annual meeting & research workshop of the biology, prevention & treatment of head & neck cancer. American Head and Neck Society. Chicago.

8. Tomik J, Skladzien M, Konior M et al. Analysis of patients under 45 years of age with cancer of the larynx. Otolaryngol Pol 2005; 59: 665-669.

9. Kreimer AR, Alberg AJ, Viscidi R et al. Gender differences in sexual biomarkers and behaviors associated with human papillomavirus-16, -18, and -33 seroprevalence. Sex Transm Dis 2004; 31(4): 247-256.

10. do Sacramento PR, Babeto E, Colombo J et al. The prevalence of human papillomavirus in the oropharynx in healthy individuals in a Brazilian population. J Med Virol 2006; 78: 614-618.

11. Herrero R, Castellsagué X, Pawlita M et al. Human papillomavirus and oral cancer: The International Agency for Research on Cancer Multicenter Study. JNCI 2003; 95: 1772-1183.

12. Mineta H, Ogino T, Amano HM et al. Human papilloma virus (HPV) type 16 and 18 detected in head and neck squamous cell carcinoma. Anticancer Res 1998; 18: 4765-4768.

13. Muños N. Human papillomavirus and cancer: the epidemiological evidence. J Clinical Virology 2000; 19: 1-5.

14. zur Hausen H. Viruses in human cancers. European J Cancer 1999; 35: 1174-1181.

15. Sanclemente G. What clinicians should know about human papilloma virus vaccines. Gac Med Mex 2003; 139: 173-183.

16. Sanclemente G. Aspectos moleculares, inmunológicos y patogénicos de la infección por el virus del papiloma humano. Rev Col Dermatol 2000; 8: 255-265.

17. Campisi G, Giovannelli L, Arico P. HPV DNA in clinically different variants of oral leukoplakia and lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004; 98: 705-11.

18. Smith EM, Ritchie EM, Summersgill KF et al. Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer 2004; 108: 766-772.

19. Gilison ML. Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Semin Oncol 2004; 31: 744-754.

20. Hoffman M, Gorogh T, Gottschlich S et al. Human papillomaviruses in head and neck cancer: 8 year-survival-analysis of 73 patients. Cancer Lett 2005; 218: 199-206.

21. Rose BR, Li W, O'Brien C. Human papillomavirus: a cause of some head and neck cancers? Med J Aus (MJA) 2004; 181: 415-416.