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2022, Number 4

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Dermatología Cosmética, Médica y Quirúrgica 2022; 20 (4)

Current antifungals and future therapeutic targets: A review article

Angulo RA, Santos OMF

Language: Spanish
References: 53
Page: 469-477
PDF size: 234.16 Kb.


ABSTRACT

Invasive fungal infections have become a threat to human health due to the high morbidity and mortality rates they are responsible for, mainly in immunocompromised patients. The available armamentarium for the treatment of these infections is restricted to a minimum amount of antifungals from the polyenes, the azoles, the echinocandins, the allylamines and the pyrimidines classes, with high toxicity, drug-to-drug interactions, and distribution problems as a result of the lack of administration routes. Given that there is an urgent need to develop new antifungal drugs, multiple substances are currently in advanced stages of research, while other molecules continue to be investigated for this end, including the orotomides, the terpenoids, the glycosyl-phosphatidylinositol inhibitors, the tetrazoles, the arylamidines, and the siderophobes, among others. This review has the purpose of informing about the new classes of antifungals and the suggestive pathways for possible therapeutic targets.


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