2022, Number 12
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Ginecol Obstet Mex 2022; 90 (12)
Relationship between estrogenic stimulating factors and biological subtypes of luminal A, luminal B and HER2 breast cancer
Corso-Restrepo DF, Solier Insuasty-Enríquez J, Oviedo-Pastrana DF, Anaya-Rodríguez AF
Language: Spanish
References: 38
Page: 959-967
PDF size: 212.40 Kb.
ABSTRACT
Background: Breast cancer represents the main neoplasia in incidence and mortality
in women, it can be divided into molecular subtypes (luminal A, luminal B, HER2 and
triple negative) having a differential prognosis and survival rates. There is literature that
demonstrates the strong association between estrogenic stimulating factors and breast
cancer, but the existing differences by molecular subtypes are not clear.
Objective: To review the recent literature and describe the relationship found between
molecular subtypes of breast cancer and estrogenic stimulating factors.
Methodology: Search in the PubMed and LILACS databases with the MeSH and
DeCS terms: breast neoplasms, molecular subtypes, risk factors, reproductive factors,
looking for the association between the antecedents of parity, age at first pregnancy
and history of breastfeeding with molecular subtypes of breast cancer (luminal A,
luminal B and HER2).
Results: A total of 366 results were obtained, excluding 352 articles when evaluating
duplicity, titles and abstracts, articles without relevance to the topic, research protocols
and articles that did not study the association of estrogenic stimulating factors with
molecular subtypes of breast cancer, resulting in 14 articles.
Conclusions: Hormone receptor-positive tumors were found to be associated with
older age at first pregnancy, longer time between menarche and first term pregnancy
and older age at last pregnancy. Breastfeeding and multiparity were found as protective
factors for luminal tumors and pure Her2.
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