2022, Number 4
<< Back Next >>
An Med Asoc Med Hosp ABC 2022; 67 (4)
Neurologic manifestations in hospitalized SARS-CoV-2 patients: a mexican cohort
Uribe-Jaimes PD, Guraieb-Chahin P, Gandarilla-Martínez NA, García-Santos RA, Treviño-Frenk I, Del RMA, Breda-Yepes M, Martínez-Carrillo FM, San EJE
Language: Spanish
References: 30
Page: 271-277
PDF size: 286.65 Kb.
ABSTRACT
Introduction: numerous neurologic manifestations in SARS-CoV-2 patients have been previously described, with only a few reports on hospitalized patients.
Objective: to describe the neurologic manifestations and the functional status at discharge of patients with confirmed diagnosis of SARS-CoV-2 admitted to the Centro Médico ABC in Mexico City
Material and methods: retrospective review of medical records of patients with confirmed diagnosis of COVID-19 admitted to the hospital between April 1st and September 30th, 2020. Demographic data, neurological and systemic manifestations, diagnostic tests and functional status at discharge were described.
Results: thirty one patients (8.6%) from 360 with diagnosis of COVID-19 reported any neurological manifestation, Most common manifestations were weakness (74.2%), headache (29%), myoglobin elevation (22.6%), hypoxic changes on MRI (22.6%), delirium (19.3%) and somnolence (16.1%). 29% of patients were asymptomatic or with no significant disability at discharge, 35.4% had mild disability, 29% had moderate to severe disability and 6.4% died.
Conclusions: neurological manifestations in patients admitted to the hospital with diagnosis of SARS-CoV-2 are low frequent. One third of patients were discharged with significant disability, specially related to muscle weakness.
REFERENCES
WHO. Coronavirus disease 2019 (COVID-19) Situation report. [December, 2020] Available in: https://www.who.int/publications/m/item/weekly-epidemiological-update---15-december-2020
Yang X, Yu Y, Xu J, Shu H, Xia J, Liu H et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med. 2020; 8 (5): 475-481.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395 (10223): 497-506.
Chen N, Zhou M, Dong X, Qu J, Gomg F, Han Y et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020; 395 (10223): 507-513.
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323 (11): 1061-1069.
Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K. Neurological manifestations of COVID-19 and other coronavirus infections: a systematic review. Clin Neurol Neurosurg. 2020; 194: 105921.
Correia AO, Feitosa PWG, Moreira JLS, Nogueira SÁR, Fonseca RB, Nobre MEP. Neurological manifestations of COVID-19 and other coronaviruses: a systematic review. Neurol Psychiatry Brain Res. 2020; 37: 27-32.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020; 77 (6): 683-690.
Xiong W, Mu J, Guo J, Lu L, Liu D, Luo J et al. New onset neurologic events in people with COVID-19 in 3 regions in China. Neurology. 2020; 95 (11): e1479-e1487.
Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Fube M et al. Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses. 2019; 12 (1): 14.
Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms. ACS Chem Neurosci. 2020; 11 (7): 995-998.
Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis. 2020; 94: 55-58.
Huang YH, Jiang D, Huang JT. SARS-CoV-2 detected in cerebrospinal fluid by PCR in a case of COVID-19 encephalitis. Brain Behav Immun. 2020; 87: 149. doi: 10.1016/j.bbi.2020.05.012.
Domingues RB, Mendes-Correa MC, de Moura Leite FBV, Cerdeira E, Zanotti D, Claro I et al. First case of SARS-CoV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease. J Neurol. 2020; 267 (11): 3154-3156.
Fadakar N, Ghaemmaghami S, Masoompour SM, Shirazi B, Akbari A, Hooshmandi S et al. A first case of acute cerebellitis associated with coronavirus disease (COVID-19): a case report and literature review. Cerebellum. 2020; 19 (6): 911-914.
Bulfamante G, Chiumello D, Canevini MP, Priori A, Mazzanti M, Centanni S et al. First ultrastructural autoptic findings of SARS-CoV-2 in olfactory pathways and brainstem. Minerva Anestesiol. 2020; 86 (6): 678-679.
Paniz-Mondolfi A, Bryce C, Grimes Z, Gordon R, Reidy J, Lednicky J et al. Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). J Med Virol. 2020; 92 (7): 699-702.
Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review. JAMA Neurol. 2020; 77 (8): 1018-1027.
Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV-2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol. 2020; 92 (6): 552-555.
Mahammedi A, Saba L, Vagal A, Leali M, Rossi A, Gaskill M et al. Imaging in neurological disease of hospitalized COVID-19 patients: an Italian multicenter retrospective observational study. Radiology. 2020; 297 (2): E270-E273.
Romero-Sánchez CM, Díaz-Maroto I, Fernández-Díaz E, Sánchez-Larsen, A, Layos-Romero A, Garcia-García A et al. Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry. Neurology. 2020; 95 (8): e1060-e1070.
Leonardi M, Padovani A, McArthur JC. Neurological manifestations associated with COVID-19: a review and a call for action. J Neurol. 2020; 267 (6): 1573-1576.
Wang L, Shen Y, Li M, Chuang H, Ye Y, Zhao H et al. Clinical manifestations and evidence of neurological involvement in 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis. J Neurol. 2020; 267 (10): 2777-2789.
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study Lancet. 2020; 395 (10229): 1054-1062.
Favas TT, Dev P, Chaurasia RN, Chakaravarty K, Mishra R, Joshu D et al. Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions. Neurol Sci. 2020; 41 (12): 3437-3470.
Nasuelli NA, Pettinaroli R, Godi L, Savoini C, De Marchi F, Mazzini L et al. Critical illness neuro-myopathy (CINM) and focal amyotrophy in intensive care unit (ICU) patients with SARS-CoV-2: a case series. Neurol Sci. 2020; 42 (3): 1-3.
Oxley TJ, Mocco J, Majidi S, Kellner C, Shoirah H, Singh I et al. Large-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med. 2020; 382 (20): e60.
Baracchini C, Pieroni A, Viaro F, Cianci V, Cattelan AM, Tiberio I et al. Acute stroke management pathway during Coronavirus-19 pandemic. Neurol Sci. 2020; 41 (5): 1003-1005.
Helms J, Tacquard C, Severac F, Leonard-Lorant I, Ohana M, Delabranche X et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Med. 2020; 46 (6): 1089-1098.
Chen T, Wu D, Chen H, Yan W, Yang D, Chen G et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020; 368: m1091.
EVIDENCE LEVEL
III