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2022, Number 3

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Dermatología Cosmética, Médica y Quirúrgica 2022; 20 (3)

Effectiveness of low level laser in alopecia, published scientific evidence

Esquerra PO, Macías MAI, Saavedra COG, Capilla GMH, Hernández CAA, Fernández-Crehuet P

Language: Spanish
References: 46
Page: 343-349
PDF size: 145.59 Kb.


ABSTRACT

Introduction: photobiomodulation or low level laser therapy (LLLT) is an emerging therapy in the treatment of various forms of alopecia; however, despite being an accesible and safe treatment, its clinical effectiveness has not been systematically evaluated.
Material and methods: a systematic review was performed in main databases to evaluate clinical effectiveness.
Results: 32 studies were included, 42% for androgenic alopecia. LLLT is an effective therapy in increasing density and thickness of terminal hair, without major adverse effects in AGA without standardized protocols. In alopecia areata, its effectiveness was found in disease activity and regrowth, except in extensive or established forms. In lichenoide lymphocytic alopecia, five reported cases show a decrease in acute symptoms such as peripillary scale and an improvement in cosmetic perception.
Conclusions: LLLT is an effective and accepted therapy for some types of alopecia (especially in AGA), without major adverse effects.


REFERENCES

  1. Chung H, Dai T, Sharma SK, Huang YY, Carroll JD y Hamblin MR, Thenuts and bolts of low-level laser (light) therapy, Ann Biomed Eng Online 2012; 40: 516-33.

  2. Gupta A, Dai T y Hamblin MR, Effect of red and near-infraredwavelengths on low-level laser (light) therapy-induced healing ofpartial-thickness dermal abrasion in mice, Lasers Med Sci 2014; 29:257-65.

  3. AlGhamdi KM, Kumar A y Moussa NA, Low-level laser therapy: a usefultechnique for enhancing the proliferation of various cultured cells,Lasers Med Sci 2012; 27:237-49.

  4. Desai S, Mahmoud BH, Bhatia AC y Hamzavi IH, Paradoxical hypertrichosisafter laser therapy: a review, Dermatol Surg 2010; 36: 291-8.

  5. Mester A y Mester A, The history of photobiomodulation: EndreMester (1903-1984), Photomed Laser Surg 2017; 35:393-4.

  6. Bouzari N y Firooz AR, Lasers may induce terminal hair growth, DermatolSurg 2006; 32:460.

  7. Wikramanayake TC, Rodríguez R, Choudhary S, Mauro LM, Nouri K,Schachner LA y Jiménez JJ, Effects of the Lexington LaserComb onhair regrowth in the c3h/hej mouse model of alopecia areata, LasersMed Sci 2012; 27: 431-6.

  8. Avram MR, Leonard RT, Epstein ES, Williams JL y Bauman AJ. Thecurrent role of laser/light sources in the treatment of male and femalepattern hair loss, J Cosmetic Laser Ther 2007; 9: 27-8.

  9. Avram MR y Rogers NE, The use of low-level light for hair growth:part i, J Cosmet Laser Ther 2009; 11:110-7.

  10. Leavitt M, Charles G, Heyman E y Michaels D, HairMax LaserComblaser phototherapy device in the treatment of male androgenetic alopecia:a randomized, double-blind, sham device-controlled, multicentretrial, Clin Drug Investig 2009; 29(5):283-92.

  11. King LE Jr, Silva KA, Kennedy VE y Sundberg JP, Lack of response tolaser comb in spontaneous and graft-induced alopecia areata in c3h/hej mice, J Invest Dermatol 2014; 134:264-6.

  12. Wikramanayake TC, Villasante AC, Mauro LM, Nouri K, Schachner LA,Pérez CI y Jiménez JJ, Low-level laser treatment accelerated hair regrowthin a rat model of chemotherapy-induced alopecia (cia), LaserMed Sci 2013; 28:701-6.

  13. Fonda-Pascual P, Moreno-Arrones OM, Saceda-Corralo D, Rodrigues-Barata AR, Pindado-Orteg C, Boixeda P y Vañó-Galván S, Effectivenessof low-level laser therapy in lichen planopilaris, J Am Acad Dermatol2018; 78:1020-3.

  14. Gerkowicz A, Bartosin´ska J, Wolska-Gawron K, Michalska-Jakubus M,Kwas´ny M y Krasowska D, Application of superluminescent diodes(sled) in the treatment of scarring alopecia: a pilot study, Photodiag andPhotodyn Ther 2019; 28:195-200.

  15. Randolph MJ, Al Salhi W y Tosti A, Lichen planopilaris and low-levellight therapy: four case reports and review of the literature aboutlow-level light therapy and lichenoid dermatosis, Dermatol 2020; 1-9.

  16. Kazemikhoo N y Mansouri P, Successful treatment of resistant discoidlupus erythematous (dle) with low-level laser therapy (lllt): a casereport, J Skin Stem Cell 2016; 3:1.

  17. Kim CY, Seo HS, Lee DJ y Kwon K, Case study on treating scarringalopecia and alopecia arreata using low level laser therapy and acupuncture,J Korean Med Ophthalm Otol Dermatol 2016; 29:182-8.

  18. Avci P, Gupta GK, Clark J, Wikonkal N y Hamblin MR, Low-level laser(light) therapy (lllt) for treatment of hair loss, Lasers Surg Med 2014;46:144-51.

  19. Kanti V, Messenger A, Dobos G, Reygagne P, Finner A, Blumeyer A yNast A, Evidence-based (s3) guideline for the treatment of androgeneticalopecia in women and in men: short version, J Eur Acad DermatolVenereol 2018; 32: 11-22.

  20. Adil A y Godwin M, The effectiveness of treatments for androgeneticalopecia: a systematic review and meta-analysis, J Am Acad Dermatol2017; 77:136-41.

  21. Orasan MS, Coneac A, Mihu CM, Mare C y Muresan A, Minoxidil andneoptide topical application reinforced by low-level laser therapy onan animal model of alopecia, Stu Chem 2015; 60:295-308.

  22. Rossi A, Cantisani C, Melis L, Iorio A, Scali E y Calvieri S, Minoxidil use indermatology, side effects and recent patents, Recent Pat Inflamm AllergyDrug Discov 2012; 6: 130-6.

  23. Han L, Liu B, Chen X, Chen H, Deng W, Yang C y Wan M, Activationof Wnt/β-catenin signaling is involved in hair growth-promoting effectof 655-nm red light and led in vitro culture model, Lasers Med Sci2018; 33:637-45.

  24. Panchaprateep R, Pisitkun T y Kalpongnukul N, Quantitative proteomicanalysis of dermal papilla from male androgenetic alopeciacomparing before and after treatment with low-level laser therapy,Lasers Surg Med 2019; 51:600-8.

  25. Gupta AK y Carviel JL, Meta-analysis of photobiomodulation for thetreatment of androgenetic alopecia, J Dermatol Treat 2019; 1-5.

  26. Wang S, Seth D, Ezaldein H, Tripathi R, Merati M, Muakkassa F y ScottJ, Shedding light on the fda’s 510 (k) approvals process: low-level lasertherapy devices used in the treatment of androgenetic alopecia, JDermatol Treat 2018; 30:489-91.

  27. Pindado-Ortega C, Saceda-Corralo D, Buendía-Castaño D, Fernández-González P, Moreno-Arrones ÓM, Fonda-Pascual P y Vañó-Galván S,Estudio transversal acerca de los hábitos de prescripción en alopeciaandrogénica de los dermatólogos en España en 2017, Actas Dermosifiliogr2018; 109:536-42.

  28. Kim TH, Kim NJ y Youn JI, Evaluation of wavelength-dependent hairgrowth effects on low-level laser therapy: an experimental animalstudy, Laser Med Sci 2015; 30:1703-9.

  29. Shin H, Jo SJ, Kim DH, Kwon O y Myung SK, Efficacy of interventionsfor prevention of chemotherapy-induced alopecia: a systematicreview and meta-analysis, Int J Cancer 2015; 136:442-54.

  30. Yamazaki M, Miura Y, Tsuboi R y Ogawa H, Linear polarized infraredirradiation using Super Lizer is an effective treatment for multipletypealopecia areata, Int J Dermatol 2003; 42:738-40.

  31. Waiz M, Saleh AZ, Hayani R y Jubory SO, Use of the pulsed infrareddiode laser (904 nm) in the treatment of alopecia areata, J Cosm Laser2006, 8:27-30.

  32. Abdelhalim NM, Efficacy of low level laser therapy in the treatmentof alopecia areata, Int J Physiother Res 2014; 2:460-5.

  33. Satino JL y Markou M, Hair regrowth and increased hair tensilestrength using the HairMax LaserComb for low-level laser therapy, IntJ Cos Surg Aest Dermatol 2003; 5:113-7.

  34. Kim H, Choi JW, Kim JY, Shin JW, Lee SJ y Huh CH, Low level lighttherapy for androgenetic alopecia: a 24-week, randomized, doubleblind.Sham device-controlled multicenter trial, Dermatol Surg 2013;39(8):1177-83.

  35. Lanzafame RJ, Blanche RR, Chiacchierini RP, Kazmirek ER y Sklar JA,The growth of human scalp hair in females using visible red light laserand led sources, Lasers Surg Med 2014; 46:601-7.

  36. Lanzafame RJ, Blanche RR, Bodian AB, Chiacchierini RP, Fernández-Obregón A y Kazmirek ER, The growth of human scalp hair mediatedby visible red light laser and led sources in males, Lasers Surg Med 2013;45:487-95.

  37. Jiménez JJ, Wikramanayake TC y Bergfeld W, Efficacy and safety ofa low-level laser device in the treatment of male and female patternhair loss: a multicenter, randomized, sham device-controlled, doubleblindstudy, Am J Clin Dermatol 2014; 15:115-27.

  38. Tabaie SM, Berenji Ardestani H y Azizjalali MH, The effect of onesession low level laser therapy of extracted follicular units on the outcomeof hair transplantation, J Lasers Med Sci 2016; 7:26-9.

  39. Barikbin B, Khodamrdi Z, Kholoosi L, Akhgri MR, Haj Abbasi M,Hajabbasi M y Akbarpour S, Comparison of the effects of 665 nmlow level diode Laser Hat versus and a combination of 665 nm and808 nm low level diode Laser Scanner of hair growth in androgenicalopecia, Journal of Cosmetic and Laser Therapy 2017. doi: 10.1080/14764172.2017.1326609.

  40. Munck A, Gavazzoni MF y Trueb RM, Use of low-level laser therapyas monotherapy or concomitant therapy for male and female androgeneticalopecia, Int J Trichology 2014; 6:45-9.

  41. Esmat SM, Hegazy RA, Gawdat HI, Abdel Hay RM, Allam RS, ElNaggar R y Moneib H, Low level light-minoxidil 5% combination versuseither therapeutic modality alone in management of female patternedhair loss: a randomized controlled study, Lasers Surg Med 2017;49:835-43.

  42. Friedman S y Schnoor P, Novel approach to treating androgenetic alopeciain females with photobiomodulation (low-level laser therapy),Dermatol Surg 2017; 43:856-67.

  43. Suchonwanit P, Chalermroj N y Khunkhet S, Low-level laser therapyfor the treatment of androgenetic alopecia in Thai men and women:a 24-week, randomized, double-blind, sham device-controlled trial,Lasers Med Sci 2019; 34:1107-14.

  44. Mai-Yi Fan S, Cheng YP, Lee MY, Lin SJ y Chiu HY, Efficacy and safetyof a low-level light therapy for androgenetic alopecia: a 24-week, randomized,double-blind, self-comparison, sham device-controlled trial,Dermatol Surg 2018; 44:1411-20.

  45. García PN, Andrino RL, Gómez C y González HP, Use of helmet withcombined low-level laser therapy, light-emitting diodes, and magneticfield technologies for hair growth treatments of male androgenic alopeciain adult patients,uime 2019; 5:16.

  46. Gentile P, Dionisi L, Pizzicannella J, De Angelis B, De Fazio D y GarcovichS, A randomized blinded retrospective study: the combineduse of micro-needling technique, low-level laser therapy and autologousnon-activated platelet-rich plasma improves hair re-growthin patients with androgenic alopecia, Expert Opin Biol Ther 2020; 20:1099-109.




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