Latorre-Rodríguez AR, Rodríguez-Chavarría MA, Acosta-Forero BJ, Ricaurte-Guerrero O

Language: Spanish
References: 14
Page: 794-802
PDF size: 342.10 Kb.

ABSTRACT

Introductions: Non-Hodgkin's lymphomas are a heterogeneous group of neoplasms hematolymphoid, with main lymph node manifestation; a small percentage have an extra-nodal origin. Some cases of non-Hodgkin's lymphomas have been described. Primaries of the ovary and, in general, of the female genitourinary duct. Because of his they infrequently pose a diagnostic, clinical and pathological challenge. We report the case of a patient with primary ovarian non-Hodgkin's lymphoma, who underwent primary surgical cytoreduction and adjuvant treatment with systemic chemotherapy. The bibliography around the criteria is reviewed diagnosis and prognosis of the disease.
Clinical case: A 65-years-old patient who presented constitutional syndrome and urinary irritative symptoms, her vital signs at the admission were normal, at the physical examination bilateral grade 2 edema in lower limbs and mucocutaneous paleness was observed, heterogeneous hypochromic microcytic anemia, thrombocytosis and also a right complex ovarian mass were documented during the hospitalization, for this reason was treated with primary surgical reduction, the histopathological result was Ovarian Primary Non Hodgkin B-cell Lymphoma, for that reason systemic adjuvant chemotherapy with R-CHOP scheme was initiated, at the ten month follow-up radiological and nuclear examinations were performed confirming the remission of the disease.
Conclusions: Primary ovarian non-Hodgkin lymphoma is an unusual extra-nodular hematolymphoid neoplasm that requires a histopathological confirmation. The prognosis according to the literature review for the disease limited to the ovary has an overall survival rate of 79% to 10 years after diagnosis. More studies are required to characterize the prognosis and diagnostic approach of this entity.

REFERENCES

1. Swerdlow SH, Campo E, Harris NL, Jaffe ES, et al. WHOClassification of Tumours of Haematopoietic and LymphoidTissues. 4th ed. Lyon: International Agency for Researchon Cancer (IARC); 2017. Url: https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/WHO-Classification-Of-Tumours-Of-Haematopoietic-And-Lymphoid-Tissues-2017

2. Vang R, Medeiros LJ, Fuller GN, Sarris AH, et al. Non-Hodgkin’s lymphoma involving the gynecologic tract: areview of 88 cases. Adv Anat Pathol 2001; 8 (4): 200-17.http://dx.doi.org/10.1097/00125480-200107000-00002

3. Vang R, Medeiros LJ, Warnke RA, Higgins JP, et al. Ovariannon-Hodgkin’s lymphoma: a clinicopathologic study ofeight primary cases. Mod Pathol 2001; 14 (11): 1093-9.http://dx.doi.org/10.1038/modpathol.3880442

4. Nasioudis D, Kampaktsis PN, Frey M, Witkin SS, et al. Primarylymphoma of the female genital tract: An analysisof 697 cases. Gynecol Oncol 2017; 145 (2): 305-9. http://dx.doi.org/10.1016/j.ygyno.2017.02.043

5. Grigoriadis C, Tympa A, Chasiakou A, Baka S, et al. Bilateralprimary ovarian non-Hodgkin’s lymphoma and fertilitypreservation: 5-year follow-up. G Chir 2017; 38 (2): 77-9.http://dx.doi.org/10.11138/gchir/2017.38.2.077

6. Ahmad AK, Hui P, Litkouhi B, Azodi M, et al. Institutionalreview of primary non-hodgkin lymphoma of thefemale genital tract: a 33-year experience. Int J GynecolCancer 2014; 24 (7): 1250-5. http://dx.doi.org/10.1097/IGC.0000000000000201

7. Senol T, Doger E, Kahramanoglu I, Geduk A, et al. Fivecases of non-hodgkin B-cell lymphoma of the ovary. CaseRep Obstet Gynecol 2014; 2014: 392758. http://dx.doi.org/10.1155/2014/392758

8. Monterroso V, Jaffe ES, Merino MJ, Medeiros LJ. Malignantlymphomas involving the ovary. A clinicopathologic analysisof 39 cases. Am J Surg Pathol 1993; 17 (2): 154-70. http://dx.doi.org/10.1097/00000478-199302000-00007

9. Fernández-García S, Bango-Álvarez C, Corrales-CanelB, Pérez-Fernández R, et al. Linfoma primario de ovario.Prog Obstet Ginecol [Internet]. 2013; (56):432-35. Disponible en: https://www.elsevier.es/index.php?p=revista&pRevista=pdf-simple&pii=S0304501313000484&r=151

10. Medeiros LJ, O´Malley DP, Caraway NP, Vega F, et al. En:Tumors of the lymph nodes and spleen (AFIP Atlas of tumorpathology). The American Registry of Pathology. ARPPress, Washington: 2017. Url: https://www.arppress.org/tumors-lymph-nodes-spleen-p/4f25.htm

11. Aukema SM, Siebert R, Schuuring E, van Imhoff GW, et al.Double-hit B-cell lymphomas. Blood 2011; 117 (8): 2319-31. http://dx.doi.org/10.1182/blood-2010-09-297879

12. Reyna-Villasmil E, Pérez-Ortiz V. Linfoma no Hodgkinprimario de ovario: Reporte de caso. Rev PeruGinecol Obstet 2018; 64 (1): 107-111. http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2304-51322018000100016&lng=es.

13. Abulhaj-Martínez M, Alayón-Hernández N, Sotelo-Avilés R,Arévalo-Reyes E, et al. Linfoma B difuso de células grandesen ovario: presentación de un caso. Rev Chil ObstetGinecol 2013; 78 (1): 64-7. http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75262013000100012

14. Vela-Chulde JC, Paucar-González MJ, Tixi-Ramírez RE. Linfomano Hodgkin primario de ovario y su respuesta a la terapiamonoclonal: reporte de un caso en el Hospital “Carlos AndradeMarín”. J Cancerol 2017; (4): 36-40. http://www.journalofcancerology.com/pdf/jcancer_2017_02_036-040.pdf