2022, Number 09
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Ginecol Obstet Mex 2022; 90 (09)
Management of uncomplicated ectopic pregnancy with local injection of methotrexate
Miranda-Flores AF, Risco-Neyra R
Language: Spanish
References: 20
Page: 726-734
PDF size: 191.18 Kb.
ABSTRACT
Objective: To describe the experience in the care of patients with uncomplicated
ectopic pregnancy with ultrasound-guided local injection of methotrexate.
Materials and Methods: Retrospective, descriptive, case series study conducted
from January 1, 2021 to February 28, 2022 at the Instituto Nacional Materno Perinatal,
Lima, Peru. Participants had uncomplicated ectopic pregnancy treated with ultrasoundguided
local injection of methotrexate. Data were obtained from medical records.
Statistical analysis was processed in SPSS 19.
Results: 11 ultrasound-guided local methotrexate injections were performed. According
to their location 4 pregnancies were tubal, 1 cervical and 6 in cesarean scar. The
average age of the pregnant women was 34.5 years. The average number of weeks of
pregnancy was 7. The initial b-hCG concentration
potassium chloride until no heartbeat was evident. A single case received an additional
systemic dose of methotrexate. Another case resulted in hemoperitoneum, due to rupture
of ectopic pregnancy after local injection.
Conclusions: Ultrasound-guided local injection of methotrexate is an alternative
to other surgical techniques applied to treat patients with uncomplicated ectopic
pregnancy with surgical indication.
REFERENCES
Andrés MP, Campillos JM, Lapresta M, Lahoz I, et al.Management of ectopic pregnancies with poor prognosisthrough ultrasound guided intrasacular injection of methotrexate,series of 14 cases. Arch Gynecol Obstet 2012; 285:529-33. doi:10.1007/s00404-011-2044-1
Panelli DM, Phillips CH, Brady PC. Incidence, diagnosis andmanagement of tubal and nontubal ectopic pregnancies: areview. Fertility Research and Practice 2015; 1: 15. https://doi.org/10.1186/s40738-015-0008-z
Gilbert SB, Alvero R, Roth L, Polotsky A. Direct MethotrexateInjection into the Gestational Sac for Nontubal EctopicPregnancy: A Review of Efficacy and Outcomes from aSingle Institution. J Minim Invasive Gynecol 2019; 0: 1-7.https://doi.org/10.1016/j.jmig.2019.03.016
Monteagudo A, Minior VK, Stephenson C, Monda S, et al.Non-surgical management of live ectopic pregnancy withultrasound-guided local injection: a case series. UltrasoundObstet Gynecol 2005; 25: 282-88. https://doi.org/10.1002/uog.1822
Elito J, Bermudes M, Araujo J, Souza E, et. al. Conservativemanagement of cervical pregnancy with embryonic heartactivity by ultrasound-guided local injection: an eightcaseseries. J Matern Fetal Neonatal Med 2014; 27 (13):1378-81. https://doi.org/10.3109/14767058.2013.856413
Verma U, English D, Brookfield K. Conservative managementof nontubal ectopic pregnancies. Fertility andSterility 2011; 96 (6): 1391-95. doi:10.1016/j.fertnstert.2011.09.021
Wang M, Chen B, Wang J, Ma X, et al. Nonsurgical managementof live tubal ectopic pregnancy by ultrasound-guidedlocal injection and systemic methotrexate. J Minim InvasiveGynecol 2014; 21(4):642-9. https://doi.org/10.1016/j.jmig.2014.01.009
Dolinko A, Vrees R, Frishman G. Non-tubal ectopic pregnancies:an overview and treatment via local injection. JMinim Invasive Gynecol 2017; 25 (2): 287-96. http://dx.doi.org/doi: 10.1016/j.jmig.2017.07.008
Ko J, Li R, Cheung V. Caesarean scar pregnancy: a 10-year experience. ANZJOG 2015; 55: 64-69. https://doi.org/10.1111/ajo.12273
Instituto Nacional Materno Perinatal. Guías de Práctica Clínicay de Procedimientos en Ginecología. Lima: INMP. 2020.
Feichtinger W, Kemeter P. Conservative treatment ofectopic pregnancy by transvaginal aspiration under sonographiccontrol and methotrexate injection. Lancet 1987;1 (8529): 381-2.
Tzafettas J, Anapliotisb S, Zournatzia V, Boucklis A, et al.Transvaginal intra-amniotic injection of methotrexate inearly ectopic pregnancy. Advantages over the laparoscopicapproach. Early Human Development 1994; 39: 101-7.
Gerday A, Lourtie A, Pirard C, Laurent P, et al. Experiencewith medical treatment of cesarean scar ectopic pregnancy(CSEP) with local ultrasound-guided injection ofmethotrexate. Front Med 2020; 7: 564764. https://doi.org/10.3389/fmed.2020.56476
Seow K, Wang P, Huang L, Hwang J. Transvaginal sonoguidedaspiration of gestational sac concurrent with a localmethotrexate injection for the treatment of unrupturedcesarean scar pregnancy. Arch Gynecol Obstet 2013; 288:361-66. https://doi.org/10.1007/s00404-013-2765-4
Yamaguchi M, Honda R, Erdenebaatar C, Monsur M, et al.Treatment of cervical pregnancy with ultrasound-guidedlocal methotrexate injection. Ultrasound Obstet Gynecol2017; 50: 781-87. https://doi.org/10.1002/uog.17384
Uludag S, Kutuk M, Ak M, Ozgun M, et al. Comparisonof systemic and local methotrexate treatments in cesareanscar pregnancies: time to change conventionaltreatment and follow-up protocols. Eur J Obstet Gynecol2016; 206: 131-35. https://doi.org/10.1016/j.ejogrb.2016.09.010
Hafner T, Aslam N, Ross J, Zosmer N, et al. The effectivenessof non-surgical management of early interstitial pregnancy:a report of ten cases and review of the literature. UltrasoundObstet Gynecol 1999; 13: 131-36.
ACOG Practice Bulletin. Tubal Ectopic Pregnancy. Obstetrics& Gynecology 2018; 131 (3): e91-e103.
Cok T, Kalayci H, Ozdemir H, Haydardedeoglu B, et al.Transvaginal ultrasound-guided local methotrexate administrationas the first-line treatment for cesarean scarpregnancy: Follow-up of 18 cases. J Obstet Gynaecol Res 2015; 41 (5): 803-8. doi:10.1111/jog.12627
Cepni I, Geuralp O, Ocal P, Salahov R, et al. An alternativetreatment option in tubal ectopic pregnancieswith fetal heartbeat: aspiration of the embryo followedby single-dose methotrexate administration. Fertilityand Sterility 2011; 96 (1): 79-83. doi:10.1016/j.fertnstert.2011.02.058