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Colegio de Medicina Interna de México.

2022, Number 4

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Med Int Mex 2022; 38 (4)

Antisynthetase syndrome. Diagnosis, clinical manifestations and treatment. The evidence so far

Alemán-Fernández CG, Alagón-Fernández CP

Language: Spanish
References: 45
Page: 840-846
PDF size: 199.43 Kb.


ABSTRACT

In 1992, the concept of antisynthetase syndrome was proposed for the first time, an autoimmune disease included on the inflammatory myopathies. It is characterized by interstitial lung disease, non-erosive arthritis, myositis, Raynaud syndrome, fever of unknown origin and mechanic’s hands. There are 10 known antisynthetase antibodies, anti-Jo-1 is the most prevalent. Since 1975, criteria to classify the inflammatory myopathies were established, but in 2010 the criteria for the diagnosis of antisynthetase syndrome were published by Connors et al. At present, specific antibodies, clinical findings and muscle disease criteria need to be met for the diagnosis of antisynthetase syndrome, considered a different disease than dermatomyositis and polymyositis. It has been reported that clinical findings will differ among patients according to the type of antibody present or positive. There are no international consensus nor randomized trials for the management of patients with antisynthetase syndrome, but there are case reports of positive outcomes in patients treated with different immunomodulatory drugs.


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