2022, Number 1-3
<< Back Next >>
Rev Mex Ortop Ped 2022; 24 (1-3)
Antibiotic prophylaxis in pediatric orthopaedic surgery applying American Society of Health-System Pharmacists guidelines
Castro-Núñez KL, Hernández-Gómez C, Haces-García F, Ordaz-Robles T
Language: Spanish
References: 13
Page: 19-23
PDF size: 161.39 Kb.
ABSTRACT
Objective: To determine if the use of limited antibiotic prophylaxis reduces surgical site infections in pediatric orthopaedic surgery.
Material and methods: Analytic comparative study. N = 1,077 patients who underwent pediatric orthopaedic surgery at Shriners Hospital for Children Mexico from March 2018 to February 2021. Group A: 359 receiving limited antibiotic prophylaxis and group B: 718 receiving conventional antibiotic prophylaxis. Assessing their postoperative follow-up during first year in search of surgical site infection.
Results: Group A: 176 (49%) female and 183 (51%) male, five years old; 221 (68%) patients underwent soft tissue surgery and 138 (32%) patients used surgical implants. Group B: 365 (50.83%) female and 353 (49.16%) male, six years old; 442 (62%) patients underwent soft tissue surgery and 276 (38%) patients used surgical implants. The antibiotic used was cephalothin in 1,026 (95.2%) patients in both groups and clindamycin in 51 (4.7%). Group B was extended antibiotic up to 7 days postoperatively. No surgical site infections were reported.
Conclusions: Limited antibiotic prophylaxis does not modify the risk of surgical site infection compared to conventional prophylaxis, and is considered a safe strategy.
REFERENCES
Bratzler DW, Dellinger EP, Olsen KM, Perl TM, Auwaerter PG, Bolon MK et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. AJHP. 2013; 70(1): 195-283.
Dimopoulou A, Kourlaba G, Psarris A, Coffin S, Spoulou V, Zaoutis T. Perioperative antimicrobial prophylaxis in pediatric patients in Greece: Compliance with guidelines and impact of an educational intervention. J Pediatr Surg. 2016; 51(8): 1307-1311.
Gómez-Romero FJ, Navarro-Gracia F. Prevención de la infección del sitio quirúrgico: análisis y revisión narrativa de las guías de práctica clínica. Cir Esp. 2017; 95(9): 490-502. Disponible en: https://doi.org/10.1016/j.ciresp.2017.09.004
Giordano M, Squillace L, Pavia M. Appropriateness of surgical antibiotic prophylaxis in pediatric patients in Italy. Infect Control Hosp Epidemiol. 2017; 38(7): 823-831.
Haas H, Launay E, Minodier P, Cohen R, Gras-Le Guen C. Surgical and medical antibiotic prophylaxis. Arch Pediatr. 2017; 24(12): S46-S51.
Laituri C, Arnold MA. A standardized guideline for antibiotic prophylaxis in surgical neonates. Semin Pediatr Surg. 2019; 28(1): 53-56.
Morse J, Blackburn L, Hannam JA, Voss L, Anderson BJ. Compliance with perioperative prophylaxis guidelines and the use of novel outcome measures. Paediatr Anaesth. 2018; 28(8): 686-693.
So JP, Aleem IS, Tsang DS, Matlow AG, Wright JG. Increasing compliance with an antibiotic prophylaxis guideline to prevent pediatric surgical site infection. Ann Surg. 2015; 262(2): 403-408.
Wainberg SK, Santos NCL, Gabriel FC, de Vasconcelos LP, Nascimento JS, de Godoi Rezende Costa Molino C et al. Clinical practice guidelines for surgical antimicrobial prophylaxis: qualitative appraisals and synthesis of recommendations. J Eval Clin Pract. 2019; 25(4): 591-602.
Rangel SJ, Fung M, Graham DA, Ma L, Nelson CP, Sandora TJ. Recent trends in the use of antibiotic prophylaxis in pediatric surgery. J Pediatr Surg. 2011; 46(2): 366-371.
Perotti LR, Abousamra O, Rogers KJ, Miller F, Sees JP. Prophylactic antibiotics in soft-tissue procedures in children with cerebral palsy. J Child Orthop. 2018; 12(3): 279-281.
Formaini N, Jacob P, Willis L, Kean JR. Evaluating the use of preoperative antibiotics in pediatric orthopaedic surgery. J Pediatr Orthop. 2012; 32(7): 732-735.
Malone SM, Seigel NS, Newland JG, Saito JM, McKay VR. Understanding antibiotic prophylaxis prescribing in pediatric surgical specialties. Infect Control Hosp Epidemiol. 2020; 41(6): 666-671.
EVIDENCE LEVEL
III