medigraphic.com
ISSN 2007-8013 (Print)
Órgano oficial de la Universidad Autónoma de Sinaloa

2021, Number 3

<< Back Next >>

Rev Med UAS 2021; 11 (3)

Efficacy of topical treatment of ringworm of the foot with olive oil ozonated vs ketoconazole 2%

Muñoz-Estrada VF, Muñoz-Muñoz R

Language: Spanish
References: 25
Page: 177-188
PDF size: 280.33 Kb.


ABSTRACT

Introduction: Tinea pedis, or tinea pedis, is a superficial mycosis, which affects the plant and / or the back of the feet, as well as the interdigital area. It is caused by dermatophyte fungi. It predominates in males between the third and sixth decade of life, usually affects both feet, especially in plants and interdigital area, consisting of erythema, flaking and scaling, often pruritic. Due to the remarkable germicidal capacity, the use of ionized vegetable oils has been extended for the treatment of various mycotic conditions, among them tinea pedis. Material and Methods: A randomized, controlled clinical trial was conducted. All patients over 18 years of age diagnosed with tinea pedis were included and divided into two treatment groups. Ketoconazole in 2% cream was indicated in the first group of patients and ozonized olive oil of 1000 mEq / L was indicated in the second group. Results: A total of 189 patients with Tinea capitis were diagnosed. The most frequent clinical variety was interdigital and the agent that was isolated most frequently was T. Rubrum. They presented complete cure at 4 weeks of treatment of ketoconazole n = 74 (77.8%) while in the group of patients treated with ozonated oil they had complete healing n = 70 (74.4%), p= 0-580. Conclusions No statistically significant difference was found between the treatment groups.


REFERENCES

  1. Zamani S, Sadeghi G, Yazdinia F, Moosa H,Pazooki A, Ghafarinia Z, et al. Epidemiologicaltrends of dermatophytosis in Tehran,Iran: A five-year retrospective study. J MycolMed. 2016;26(4):351-8.

  2. Hayette M-P, Sacheli R. Dermatophytosis,Trends in Epidemiology and Diagnostic Approach.Current Fungal Infection Reports.2015;9(3):164-79

  3. Ilkit M, Durdu M. Tinea pedis: the etiologyand global epidemiology of a common fungalinfection. Crit Rev Microbiol.2015;41(3):374-88.

  4. Lopez-Martinez R, Manzano-Gayosso P,Hernandez-Hernandez F, Bazan-Mora E,Mendez-Tovar LJ. Dynamics of dermatophytosisfrequency in Mexico: an analysis of2084 cases. Med Mycol. 2010;48(3):476-9.

  5. Gómez Moyano E, Crespo Erchiga V, MartínezPilar L. Dermatofitosis. Piel.2016;31(8):546-59.

  6. García-Romero MT, Arenas R. New insightsinto genes, immunity, and the occurrence ofdermatophytosis. J Invest Dermatol.2015;135:655–7.

  7. Jaradat SW, Cubillos S. Krieg Low DEFB4copy number and high systemic hBD-2 andIL-22 levels are associated with dermatophytosis.J Invest Dermatol. 2014;135:750–8

  8. Ali-Shtayeh MS, Yaish S, Jamous RM, ArdaH, Husein EI. Updating the epidemiology ofdermatophyte infections in Palestine withspecial reference to concomitant dermatophytosis.J Mycol Med. 2015;25(2):116-22.

  9. Arenas R. Dermatofitosis en México. Reviberoam Micol 2002; 19: 63-67.

  10. Kutlubay Z, Yardimci G, Kantarcioglu AS,Serdaroglu S. Acral manifestations of fungalinfections. Clin Dermatol. 2017;35(1):28-39.

  11. Moureu S, Violleau F, Ali Haimoud-Lekhal D,Calmon A. Ozonation of sunflower oils: impactof experimental conditions on the compositionand the antibacterial activity of ozonizedoils. Chem Phys Lipids. 2015;186:79-85.

  12. Díaz Gómez MF, Ledea Lozano OE, GómezRegüeiferio M, Garcés Mancheño R, AlaizBarragán MS, Martínez Force E. Estudiocomparativo de la ozonización de aceites degirasol modificados genéticamente y sin modificarJ Química Nova. 2009;32:2467-72.

  13. Menendez S, Falcon L, Maqueira Y. Therapeuticefficacy of topical OLEOZON(R) inpatients suffering from onychomycosis. Mycoses.2011;54(5):e272-7.

  14. Bocci V, Borrelli E, Travagli V, Zanardi I. Theozone paradox: ozone is a strong oxidant aswell as a medical drug. Med Res Rev.2009;29(4):646-82.

  15. Campanati A, De Blasio S, Giuliano A, GanzettiG, Giuliodori K, Pecora T, et al. Topicalozonated oil versus hyaluronic gel for thetreatment of partial- to full-thickness seconddegreeburns: A prospective, comparative,single-blind, non-randomised, controlled clinicaltrial. Burns. 2013;39(6):1178-83.

  16. Bocci V. Is it true that ozone is always toxic?The end of a dogma. Toxicol Appl Pharmacol.2006;216(3):493-504.

  17. Burgassi S, Zanardi I, Travagli V, MontomoliE, Bocci V. How much ozone bactericidal activityis compromised by plasma components?J Appl Microbiol. 2009;106(5):1715-21.

  18. Lu J, Guo M, Ligui H, Wu K, Xiang Y, HuangJ, et al. Efficacy of combination of ozonatedwater with oil for treatment of tinea pedis.Zhong Nan Da Xue Xue Bao Yi Xue Ban.2018;43(2):147-51.

  19. Travagli V, Zanardi I, Valacchi G, Bocci V.Ozone and ozonated oils in skin diseases: areview. Mediators Inflamm.

  20. 2010;2010:610418.20. Mutluoglu M, Karabacak E, Karagoz H, UzunG, Ay H. Topical ozone and chronic wounds:improper use of therapeutic tools may delaywound healing. N Am J Med Sci.2012;4(11):615-6.

  21. Aerts O, Leysen J, Horst N, Lambert J,Goossens A. Contact dermatitis caused bypharmaceutical ointments containing 'ozonated'olive oil. Contact Dermatitis.2016;75(2):123-6.

  22. Valacchi G, Zanardi I, Lim Y, Belmonte G,Miracco C, Sticozzi C, et al. Ozonated oils asfunctional dermatological matrices: effectson the wound healing process using SKH1mice. Int J Pharm. 2013;458(1):65-73.

  23. Valacchi G, Fortino V, Bocci V. The dual actionof ozone on the skin. Br J Dermatol.2005;153(6):1096-100.

  24. Menendez S, Falcon L, Simon D, LandaNJM. Efficacy of ozonized sunflower oil inthe treatment of tinea pedis. 2002;45(7􀇦8):329-32.

  25. Falcón Lincheta L, Daniel Simón R, MenéndezCepero S, Landa Díaz N, Moya DuqueS. Solución para la epidermofitosis de lospies en integrantes de las Fuerzas ArmadasRevolucionarias %J Revista Cubana de MedicinaMilitar. 2000;29:98-102.




2020     |     www.medigraphic.com