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2021, Number 1

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Rev Med UAS 2021; 11 (1)

Morbidity and mortality of COVID-19 compared to Influenza in children: systematic review

Verdugo-Borbón DE, Mayorga-Inzunza A, Pérez-Gaxiola G

Language: Spanish
References: 22
Page: 72-79
PDF size: 142.56 Kb.


ABSTRACT

Introduction: The disease caused by the SARS-CoV-2 virus, COVID-19, is usually more benign in children than adults. Its impact in childhood morbimortality, in relation to other stational respiratory viruses such as influenza is not known. Objective: To compare the burden in morbimortality of COVID-19 with that of influenza in children. Methods: Studies of any design that compared the clinical outcomes of children with COVID-19 with those in children with influenza were selected. The outcomes included mortality, duration of hospital stay, and need for oxygen, mechanical ventilation, or intensive care. The search was performed in Medline, The Cochrane Library, Google Scholar, and Epistemonikos. Search and data extraction were done by two independent evaluators. Results: Of 438 articles found, 4 fulfilled the inclusion criteria. All 4 were retrospective studies, with different settings, that compared children with COVID-19 diagnosed during 2020 with children with influenza diagnosed in previous periods or years. No significant differences were found in mortality, days of stay, or oxygen, mechanical ventilation or intensive care need. The quality of evidence was considered very low. Conclusions: The morbimortality of children with COVID-19 may be similar to that of influenza, but the certainty of the evidence is very low.


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