Castañón-Olivares LR, Arreguín-Espinosa R, Ruiz-Palacios SG, López-Martínez R

Language: English
References: 32
Page: 35-40
PDF size: 60.35 Kb.

ABSTRACT

Cryptococcosis frequency is increasing in Mexico. Few epidemiologic and clinical surveys exist even though 10-15% of patients with AIDS develop this mycosis. To know the situation about the prevalence and etiological agents of cryptococcosis in our country, a study including isolated Cryptococcus spp. strains took place from 1989 to August 1998. A total of 211 Cryptococcus spp. strains obtained from patients of diverse hospital centers in Mexico City were studied. This study describes cryptococcosis epidemiological data, in our country. C. neoformans was the dominant isolation (97.15%), followed by two C. albidus isolations and one C. uniguttulatus isolation. 92.5% of the strains was isolated from cerebral spinal fluid and the remaining were from bone marrow, blood, ganglion, sputum, bronchial lavage and liver biopsy. AIDS was the principal opportunistic factor (85%). Strains were found prevails in males (87.3%). It was found that the age groups where the disease appears most frequently are in the fourth (37.5%) and third (33.8%) decade of life. Finally, the isolation frequency of the C. neoformans var. neoformans (vn) and var. gattii (vg) obtained in this study (vn 86.7% and vg 10.4%) was compared with the ones registered in Argentina (vn 97.6%, vg 2.4%); Brazil (vn 83.3%, vg 15.8%); Cuba (vn 97.6%, vg 2.4%); Paraguay (vn 0 %, vg 100.0%); Puerto Rico (vn 100.0%, vg 0%) and Venezuela (vn 66.7%, vg 29.6%).

REFERENCES

1. Arastéh K., F. Staib, G. Grosse, U. Futh and M. L’Age. 1996. Cryptococcosis in HIV infection of man: an epidemiological and immunological indicator? Zbl. Bakt. 284:153-163.

2. Bava A. J. 1987. Diferenciación en pares serotipicos de cepas de Cryptococcus neoformans aisladas en nuestro medio. Rev. Arg. Micol. 10:12-13.

3. Bava A. J. and R. Negroni. 1990. Estudio del primer caso autóctono argentino de criptococosis producida por Cryptococcus neoformans var. gattii. Rev. Iberoamer. Micol. 7:39-42.

4. Bava A. J. and R. Negroni. 1992. The epidemiological characteristics of 105 cases of cryptococcosis diagnosed in the Republic of Argentina between 1981-1990. Rev. Inst. Med. Trop. Sao Paulo 34:335-340

5. Bava A. J., R. Negroni, A. Arechavala, A. M. Robles and M. Bianchi. 1997. Cryptococcosis associated with AIDS in the Muñiz Hospital of Buenos Aires. Mycopathologia 140:13-17.

6. Calvo B., O. Fishmman, A. Pignatari, R. Del Bianco and L. Zaror. 1990. Variedades y serotipos de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en Sâo Paulo, Brasil. Rev. Inst. Med. Trop. Sao. Paulo 32:480-482.

7. Castañón-Olivares L. R., R. López-Martínez, G. Barriga- Angulo and C. Ríos-Rosas. 1997. Cryptococcus neoformans var. gattii in an AIDS patient: first observation in Mexico. J. Med. Vet. Mycol. 35:57-59.

8. Conti-Díaz I. A. 1990. Highlights of cryptococcosis in Uruguay. Bull. Soc. Fr. Mycol. Med. 19:83-90.

9. De Melo N. T., C. S. Lacaz, C. E. Charbel, A. D. Pereira, E. M. Heins-Vaccari, A. S. Franca-Netto, L. R. Machado and J. A. Livramento. 1993. Quimiotipagen do Cryptococcus neoformans. Revisao da literatura. Novos dados epidemiológicos sobre a cryptococose. Nossa experiencia com o emprego do medio de CGB. No estudo daquela levedura. Rev. Inst. Med. Trop. Sao. Paulo 35:469-478.

10. Fernández-Andreu C., G. Martínez-Machín, L. P. Alvarez-Bernal, R. Rodríguez-Morales and C. Alvarez-Herrera. 1990. Cryptococcus neoformans var. neoformans isolated in Havana City. Mem. Inst. Oswaldo. Cruz 85:245.

11. Fernández-Andreu C., G. Martínez-Machín, J. Menendez de San Pedro and B. Oramaz-Rodríguez. 1991. Identificación de variedades de Cryptococcus neoformans mediante la utilización de medios de cultivo. Rev. Cubana. Med. Trop. 43:100-103.

12. Fernández-Andreu C., G. Martínez-Machín, M. T. Illnait-Zaragozi, M. Perurena-Lancha and M. González-Miranda. 1998. The identification of Cryptococcus neoformans var. neoformans in Cuban clinical isolates. Rev. Cub. Med. Trop. 50:167-169.

13. Fromtling R. A., G. K. Abruzzo and A. Ruiz. 1989. Virulence and antifungal susceptibility of environmental and clinical isolates of Cryptococcus neoformans from Puerto Rico. Mycopathologia 106:163-166.

14. Garza-Garza D., J. L. Buendía-Uribe, E. Martínez-Cruz and B. Arguero-Liceaga. 1995. Caracterización de cepas de Cryptococcus neoformans aisladas de pacientes con el síndrome de inmunodeficiencia adquirida (SIDA). Rev. Lat-amer. Microbiol. 37:273-279.

15. Greer D. L. 1978. Cryptococcosis in Colombia: epidemiological and clinical aspects. Proc. IV conference on the mycoses the black and white yeast. Pan American Health Organization. WHO. Scientific publication. 356:185-193.

16. Gutiérrez J. and J. Liebana. 1993. Immunological methods for the detection of structural components and metabolites of bacteria and fungi in blood. Ann. Biol. Clin. 51:83-90.

17. Kordossis T., A. Avlami, A. Velegraki, I. Stefanou, G. Georgakopoulus, C. Papalambrou and N. J. Legakis. 1998. First report of Cryptococcus laurentii meningitis and a fatal case of Cryptococcus albidus cryptococcaemia in AIDS patients. Med. Mycol. 36: 335-339.

18. Kwon-Chung K. J. and J. E. Bennett. 1984. Epidemiologic differences between the two varieties of Cryptococcus neoformans. Am. J. Epidemiol. 120:123-130.

19. Lacaz C. S. and M. C. Rodrígues. 1983. Serotipagem do Cryptococcus neoformans. Rev. Bras. Med. 40:297-300.

20. López-Martínez R., J. L. Soto-Hernández, L. Ostrosky-Zeichner, L. R. Castañón-Olivares, V. Angeles-Morales and J. Sotelo. 1996. Cryptococcus neoformans var. gattii among patients with cryptococcal meningitis in Mexico. First observations. Mycopathologia 134:61-64.

21. Mendes C. M. F., W. Francisco, L. F. G. Siqueira and M. J. Silveira. 1989. Sorogrupagem de Cryptococcus neoformans. Epidemiological Note. Rev. Microbiol. S. Paulo 20:333-336.

22. Montero-Gei F. and F. Alvarado. 1978. Clinical and epidemiological aspects of cryptococcosis in Costa Rica. Procc. IV Conference on the mycoses the black and white yeast. Pan American Health Organization. WHO. Scientific publication. 356:195-198.

23. Nishikawa M. M., O. D. SantAnna, M. S. Lazera and B. Wanke. 1996. Use of D-proline assimilation and CGB medium for screening Brazilian Cryptococcus neoformans isolates. J. Med. Vet. Mycol. 34:365-366.

24. Paula C. R., C. H. Ito, A. Purchio, W. Gambale, B. Correa and P. S. Minami. 1988. Biochemical serotyping and other physiological characteristics of 40 Cryptococcus neoformans samples isolated from clinical materials in Brazil. Rev. Iberoamer. Micol. 5:105.

25. Robinson R. D. 1995. Parasitic infections associated with HIV/AIDS in the Caribbean. Bull. Pan. Am. Health. Organ. 29:129-137.

26. Rozenbaum R., A. J. Ríos-Goncalves, B. Wanke, M. J. Caiuby, H. Clemente, M. Dos Santos Lazera, P. C. Fialho-Monteiro and A. T. Londero. 1992. Cryptococcus neoformans varieties as agents of cryptococcosis in Brazil. Mycopathology 119:133-136.

27. Rozenbaum R. and A. J. Ríos-Goncalves. 1994. Clinical-epidemiological study of 171 cases of cryptococcosis. Clin. Infect. Dis. 18:369-380.

28. Sierra L. O., M. Suárez and A. Rodríguez-French. 1996. Cryptococcus neoformans meningitis in patients with AIDS in Saint Thomas Hospital. Rev. Med. Panamá 21:46-50.

29. Silva-Rosas C., A. Afani, M. Fruns, M. A. Guzmán and C. Sepúlveda. 1999. Meningitis in subjects with human immunodeficiency virus infection. Neurología 14:62-66.

30. Villanueva E., M. Mendoza, E. Torres and M. B. Albornoz. 1989. Serotipificación de 27 cepas de Cryptococcus neoformans aisladas en Venezuela. Acta Científica Venezolana 40:151-154.

31. Wells G. M., A. Gajjar, T. A. Pearson, K. L. Hale and J. L. Shenep. 1998. Brief report. Pulmonary cryptosporidiosis and Cryptococcus albidus fungemia in a child with acute lymphocytic leukemia. Med. Pediatr. Oncol. 31: 544-546.

32. Zerpa R., L. Huicho and A. Guillen. 1996. Modified India Ink preparation for Cryptococcus neoformans in cerebrospinal fluid specimens. J. Clin. Microbiol. 34:2290-2291.