2021, Number 6
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Acta Ortop Mex 2021; 35 (6)
Andean children with aneurysmal bone cyst treated with polidocanol (use off-label)
Ríos-Méndez R, Espin-Villamarin L, Rovalino-Troya C, Rosero-Lema V, Barona-Freire E, Reinoso-Recalde D
Language: Spanish
References: 14
Page: 529-533
PDF size: 247.44 Kb.
ABSTRACT
Introduction: The aneurysmal bone cyst is a rare benign but aggressive osteolytic tumor for which there is still no ideal treatment, the reports on treatment by sclerotherapy in the pediatric population are scarce and in our region even less. The objective is to communicate the experience of the treatment of aneurysmal bone cyst with polydocanol 3%.
Material y methods: Retrospective, descriptive and cross-sectional study. Period: June/2017 to June/2021. Inclusion: patients with histological diagnosis of aneurysmal bone cyst; Under general anesthesia and fluoroscopic guidance, intralesional puncture with 16G needle was performed through which 3% polydocanol was slowly administered. Data: medical history. Quantitative variables shall be expressed in measures of central tendency and dispersion; qualitative variables shall be expressed as frequencies or percentages.
Results: Nine consecutive patients were included, all of whom had pain and tumor in one of the extremities. Gender: 3 female and 6 male. Age: median 10.5 years (range: 2-15.1). Weight: median 32.8 kg (range: 11-44.5). Total procedures: 44; procedures per patient: mean 4.9 (SD: ± 2.0). Procedure time: mean 33.9 minutes (SD: ± 18.3); radiation: mean 1.34 mGy (SD: ± 1.55). Hospitalization: one day, except one patient. Complications: skin damage in one case, no recurrences follow-up: 12 to 50 months.
Conclusion: In this pediatric series, polydocanol 3% was useful and effective for the treatment of aneurysmal bone cyst, with few complications. One disadvantage is that it requires several sessions and in addition, no significant difference has been demonstrated between other forms of treatment in terms of the recurrence rate.
REFERENCES
Ye Y, Pringle LM, Lau AW, Riquelme DN, Wang H, Jiang T, et al. TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB. Oncogene. 2010; 29(25): 3619-29.
Hauschild O, Lüdermann M, Engelhardt M, Baumhoer D, Baumann T, Elger T, et al. Aneurysmal bone cyst (ABC): treatment options and proposal of a follow-up regime. Acta Orthop Belg. 2016; 82(3): 474-83.
Varshney MK, Rastogi S, Khan SA, Trikha V. Is sclerotherapy better than intralesional excision for treating aneurysmal bone cyst? Clin Orthop Relat Res. 2010; 468(6): 1649-59.
Bavan L, Wijendra A, Kothari A. Efficacy of treatment interventions for primary aneurysmal bone cyst: a systematic review. Bone JT Open. 2021; 2(2): 125-33.
Mohan R, Sreekumaran GT. Secondary aneurysmal bone cyst of the scapula treated by CT guided percutaneous polidocanol injection. A case report. J Clin Diagn Res. 2016; 10(12): RD04-6.
Rastogi S, Varshney MK, Trikha V, Khan SA, Choudhury B, Safaya R. Treatment of aneurysmal bone cyst with percutaneous sclerotherapy using polidocanol. A review of 72 cases with long-term follow-up. J Bone Join Surg Br. 2006; 88(9): 1212-6.
Brosjo O, Pechon P, Hesla A, Tsagozis P, Bauer H. Sclerotherapy with polidocanol for treatment of aneurysmal cyst bone. Acta Orthop. 2013; 84(5): 502-5.
Wootton-Gorges SL. MR Imaging of primary bone tumors and tumor-like conditions in children. Magn Reson Imagine Clin N Am. 2009; 17(3): 469-87.
Park HY, Yang SK, Sheppard WL, Hedge V, Zoller SD, Nelson SD, et al. Current management of aneurysmal cyst bone. Curr Rev Musculoskelet Med. 2016; 9(4): 435-44.
Peraud A, Drake JM, Armstrong D, Hedden D, Babyn P, Wilson G. Fatal ethibloc embolization of vertebrobasilar system following percutaneous injection into aneurysmal bone cyst of the second cervical vertebral. AJNR Am J Neuroradiol. 2004; 25(6): 116-20.
Chartrand-Lefebvre C, Dubois J, Roy D, Mercier C, Raymond J. Direct intraoperative sclerotherapy of an aneurysmal bone cyst of the sphenoid. AJNR Am J Neuroradiol. 1996; 17(5): 870-2.
Gupta G, Pandit RS, Jerath N, Narasimhan R. Severe life-threatening hipersentivity reaction to polidocanol in a case of recurrent aneurysmal bone cyst. J Clin Orthop Trauma. 2019; 10(2): 414-7.
Ebrahimi SRS, Enamzadeh E, Babaei H. An evidence-based review of off-label uses of polidocanol. Curr Clin Pharmacol. 2017; 12(4): 223-30.
Grabois M, Oliveira E, Carvalho M. Childhood cancer and pediatric oncologic care in Brazil: access and equity. Cad Saúde Pública. 2011; 27(9): 1711-20.
EVIDENCE LEVEL
IV