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2004, Number 6

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Rev Med Inst Mex Seguro Soc 2004; 42 (6)

Transfusion-Related Acute Lung Injury (TRALI): Acute Pulmonary Damage From Transfusion

Rodríguez MH

Language: Spanish
References: 27
Page: 501-505
PDF size: 356.36 Kb.


ABSTRACT

Clinical symptoms of TRALI (transfusion-related lung injury) are observed during transfusion or in the six hours after transfusion. Lung infiltrates, bronchial secretions, and hypoxia are part of the syndrome. The cause has been attributed to leucocyte antibodies and to lipids from stored plasma of blood components. Frequency is 1 in 7900 plasma transfusions, with 6 to 10 % mortality. According to the U.S. FDA (U.S. Food and Drug Administration), during 1976-1998 TRALI was considered the third cause of blood transfusion death. Most affected patients are those being treated for malignant hemopathies and those who have undergone openheart surgery. Its diagnosis is frequently overlooked because symptoms are often disguised by other symptoms affecting these patients. Physicians from hematology, open-heart surgery and intensive care units must report to the transfusion medicine service physician any acute respiratory distress observed in order to investigate the possible transfusion relation. In accordance with prevention of TRALI for patients, the following are recommended: employing blood transfusion components, leukocytereduced, with less than 72 hr of storage and irradiated; for red blood cells, washed units are recommended.


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