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2022, Number 1

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Rev Educ Bioquimica 2022; 41 (1)

Melanoma: mecanismos de acción y de secreción del factor de crecimiento transformante beta (TGF-β)

Pérez-Calixto M, Anaya-Rubio I, Mota-López C, Macías-Silva M

Language: Spanish
References: 37
Page: 18-27
PDF size: 479.25 Kb.


ABSTRACT

Melanoma is an aggressive and mortal skin cancer. The transforming growth factor beta (TGF-β) signaling pathway acts as a tumor suppressor or promoter depending on the stages of cancer. In the present work, we focused on the secretion of TGF-β, which can be transported by extracellular vesicles (EVs) secreted by cancer cells to educate target cells and favor tumorigenesis


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